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http://dx.doi.org/10.12925/jkocs.2017.34.3.427

Anti-obesity Effects of Genistein in Female Ovariectomy-induced Obese Mice  

Jeong, Sun-Hyo (Division of Biomedical Engineering & Health, Science Management, College of Science & Technology, Mokwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.34, no.3, 2017 , pp. 427-435 More about this Journal
Abstract
To investigate whether genistein regulates menopause-induced obesity, it was studied the effects of genistein on anti-obesity effects in female ovariectomized (OVX) mice, an animal model of postmenopausal women. 7-week-old female mice (C57BL/6J) were randomly divided into three groups. All the animals received a high fat diet or a high fat diet supplemented with genistein for 8 weeks and variables and determinants of obesity were measured. The OVX mice had significantly higher body weight and adipose tissue mass than sham mice. However, genistein supplementation reduced body weight, adipose tissue mass, and adipocyte size of OVX mice. The OVX mice treated with genistein had significantly lower levels of serum triglycerides and total cholesterol than the vehicle-treated OVX mice. Lipid accumulation in liver was also markedly decreased by genistein in OVX mice. The results suggest that genistein can effectively prevent adiposity, adipocyte phertrophy, and llipid disorders caused by ovariectomy. Moreover, this study may contribute to the alleviation of metabolic syndrome, including obesity and hyerlipidemia in postmenopausal women.
Keywords
ovariectomized mice; obesity; genistein; body weight; adipose tissue mass;
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