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http://dx.doi.org/10.12925/jkocs.2016.33.4.762

A Study on Anti-oxidative, Anti-inflammatory, and Melanin Inhibitory Effects of Chrysanthemum Sibiricum Extract  

You, Seon-hee (Department of Bioengineering, Konkuk University)
Moon, Ji-sun (Department of Beauty Health, Jungwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.33, no.4, 2016 , pp. 762-770 More about this Journal
Abstract
The purpose of this study is to observe how Chrysanthemum Sibiricum Extract has anti-oxidant activity, cytotoxicity for skin cells, and anti-inflammatory and melanin inhibitory effects in order to find the development possibility of Chrysanthemum Sibiricum Extract as the ingredient of a functional cosmetic product. According to the analysis, Chrysanthemum Sibiricum Extract was found to have high contents of polyphenols and flavonoids and excellent DPPH radical scavenging activity. The extract had no significant cytotoxicity for Raw 264.7 cell and B16F10 cell and significantly inhibited the creation of NO induced LPS in Raw 264.7 cell so as to present anti-inflammatory effect. In B16F10 cell, melanin creation was induced with ${\alpha}$-MSH, and then melanin biosynthesis inhibition was measured. As a result, melanin creation was inhibited in the concentration dependence way. Given the results, it is considered that Chrysanthemum Sibiricum Extract is applicable as the ingredient of a functional cosmetic product that has low cytotoxicity for skin cells, high anti-oxidant activity, anti-inflammatory effect, and whitening effect.
Keywords
antioxidative activity; Chrysanthemum zawadskii; Functional cosmetics Melanin; Nitric oxide;
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1 D. S. Jang, K. H. Park, J. R. Lee, T. J. Ha, Y. B. Park, S. H Nam, M. S. Yang. Antimicrobial activities of Sesquiterpene lactones isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale. J Korean Soc Agric Chem Biotechnol. 42, 17-179 (1999).
2 S. H. Lee, J. S. Lee. Production and characteristics of antidandruffy compound from Chrysanthemum zawadskii. Kor J Microbiol Biotechnol. 35, 220-225 (2007).
3 M. R. Hyun, Y. S. Lee, Y. H. Park. Antioxidative Activity and Flavonoid Content of Chrysanthemum zawadskii Flowers. Kor. J. Hort. Sci. Technol. 29(1), 68-73 (2011).
4 J. H. Woo, S. L. Shin, Y. D. Chang, C. H. Lee. Antioxidant Effect according to Extraction Method in extract of Dendranthema zawadskii var.yezoense and Cosmos bipinnatus. Kor. J. Hort. Sci. Technol. 28(3), 462-468 (2010).
5 S. H. Lee, I. G. Hwang, J. W. Nho, Y. D. Chang, C. H. Lee, K. S. Woo, H. S. Jeong. Quality Characteristics and Antioxidant Activity of Chrysanthemum indicum L., Chrysanthemum boreale M. and Chrysanthemum zawadskiiK. Powdered Teas. J Korean Soc Food Sci Nutr. 38(7), 824-831 (2009).   DOI
6 M. D. Coleman, S. Fernandes, L. Khanderia. A preliminary evaluation of a novel method to monitor a triple antioxidant combination (vitamins E, C, and ${\alpha}$-lipoic acid) in diabetic volunteers using in vitro methaemoglobin formation. Environ. Toxicol. Phar. 14, 69-75 (2003).   DOI
7 M. O. Namiki. Antioxidants and antimutagens in food. Crit. Rev. Food Sci. 29, 273-300 (1990).   DOI
8 H. Masaki, S. Sakaki, T. Atsumi, H. Sakurai. Active-oxygen scavenging activity of plant extracts. Biol. Pharm. Bull. 18, 162-166 (1995).   DOI
9 K. B. Kim, K. H. Yoo, H. Y. Park, J. M. Jeong. Anti-oxidative activities of commercial edible plant extracts distributed in Korea. J. Korean Soc. Appl. Biol. Chem. 49, 328-333 (2006).
10 G. M. Williams, C. X. Wang, M. J. Iatropoulos. Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. II. Chronic feeding studies. Food Chem. Toxicol. 28, 799-806 (1990).   DOI
11 A. L. Branen. oxicological and biochemistry of butylated hydroxyanisole and butylated hydroxytolene. J. Am. Oil Chem. Soc. 52, 59-63 (1975).   DOI
12 H. M. Seog, M. S. Seo, H. M. Kim, M. S. Ahn, Y. T. Lee. Antioxidative activity of barley polyphenol extract (BPE) separated from pearling by-products. Korean J. Food Sci. Technol. 34, 889-892 (2002).
13 J. Yamakoshi, F. Otsuka, A. Sano, S. Tokutake, M. Saito, M. Kikuchi. Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds, Pigment. Cell Research. 16, 629 (2003).   DOI
14 A. Snchez-Ferre, J. N. Rodriguez-Lopez, F. Garcia-Canovas, F. Garcia-Carmona. Tyrosinase: A comprehensive review of its mechanism, Biochim. Biophys. Acta., 1247(1), 1 (1995).   DOI
15 M. I. Moreno, M. I. Isla, A. R. Sampietro, M. A. Vattuone. Comparison of the free radical scavenging activity of propolis from several region of argentina. J. Enthrophamacol. 71(1-2), 109-114 (2000).   DOI
16 J. H. Woo, C. H. Lee. Effect of Harvest Date on Antioxidant of Dendranthema zawadskii var. latilobum (Maxim.) Kitam and D. zawadskiivar. yezoense (Maek.). Korean J. Plant Res. 21(2), 128-133 (2008).
17 S. H. Sin, Y. Y. Choi. Analysis of Essential Oil from Chrysanthemum sibricum and the Comparision with Essental Oils from Some Chrysanthemum sibricum spp. Kor. J. Pharmacog. 13(4), 153-156 (1982).
18 T. J. Kim, T. R. Lee, H. K. Park. Simultaneous Determination of Chlorogenic Acid and Linarin in Chrysanthemum Sibircum Fisherby Liquid Chromatography. Journal of the Korea Chemical Society. 35(6), 720-724 (1991).
19 H. S. Kwon, T. J. Ha, S. W. Hwang, Y. M. Jin, S. H. Nam, K. H. Park, M. S. Yang. Cytotoxic Flavonoids from the whole Plants of Chrysanthemum Zawadskii Herbich var. latilobum Kitamura. Journal of life science. 16(5), 746-749 (2006).   DOI
20 T. Gutfinger. Polyphenols in olive oils. J. Am. Oil Chem. Soc. 58(11), 966-968 (1981).   DOI
21 M. S. Blois. Antioxidant determination by the use of a stable free radical. Nature. 181, 1199-1200 (1958).   DOI
22 K. Azuma, M. Nakayama, M. Koshica, K. Lppoushi, Y. Yamaguchi, K. Kohata Y. Yamaguchi, H. Ito, H. Higashio. Phenolic antioxidants from the leaves of Corchorus oltiorius L. J. A. gric. Food Chem. 47, 3963-3966 (1999).   DOI
23 B. N. Ames, M. K. Shigenaga, T. M. Hagen. Oxidants, antioxidants, and the degenerative diseases of aging. National Acad Science. 90(17), 7915-7922 (1993).   DOI
24 M. Wettasinghe, F. Shahidi. Scavenging of reactiveoxigen species and DPPH free radicals by extracts of borage and evening primrose meals. Food Chem. 70, 17-26 (2000).   DOI
25 D. T. Sawyer, J. S. Valentine. How super is superoxide? ACC. Chem. Res. 14, 393 (1981).   DOI
26 I. Fridorich. Biological effects of the superoxide radical. Arch. Biophys. 247, 1-11 (1986).   DOI
27 J. W. Nho, I. G. Hwang, E. M. Joung, H. Y. Kim, S. J. Chang, H. S. Jeong. Biological activities of Magnolia denudata Desr. flower extracts. J. Korean Soc. Food Sci. Nutr. 38, 1478-1484 (2009).   DOI
28 W. C. Lee, A. J. Kim, S. Y. Kim. The study on the functional materials and effects of mulberry leaf. Food Sci. Ind. 36, 2-14 (2003).
29 P. A. Cerutti. Oxy-radicals and cancer. Lancet. 344, 862-863 (1994).   DOI
30 W. M. Cort. Antioxidant activity of tocopherols, ascorbyl palmitate, and ascorbic acid and their mode of action. J. Am. Oil Chem. Soc. 51, 321-325 (1974).   DOI
31 Y. A. Jang, H. N. Kim, J. C. Yang, J. W. Lee, B. A. Kim, J. T. Lee. A study on the possibility of extracts from Sparassis crispa for cosmetic ingredients. J. of Korean Oil Chemists Soc. 32(4), 721-739 (2015).
32 J. Cabanes, S. Chazarra, F. Garcia-Carmona. Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. J. Pharm. Pharmacol. 46, 982-985 (1994).   DOI
33 J. Yamakoshi, F. Otsuka, A. Sano, S. Tokutake, M. Saito, M. Kikuchi, Y. Kubota. Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds. Pigm. Cell Res. 16, 629-638 (2003).   DOI
34 E. J. Seo, E. S. Hong, M. H. Choi, K. S. Kim, S. J. Lee. The Antioxidant and skin whitening effect of artemisia iwayomogi extract, Korean J. Food sci. Technol. 44(1), 89-93 (2012).   DOI
35 Y. Y. Kim, S. Y. Lee, D. S. Yim. Biological Activities of Linarin from Chrysanthemum zawadskii var. latilobum. Yakhak Hoeji. 45(6), 604-610 (2001).
36 S. H. Lee, J. S. Lee. Production and characteristics of antidandruffy compound from Chrysanthemum zawadskii. Kor J Microbiol Biotechnol. 35, 220-225 (2007).
37 C. S. Yook. Colored medicinal plants of Korea. Academybook. Korea. p. 588-589 (1997).
38 R. J. Lim. Korean Flora. Agricultural puvlisher. Seoul. p.186 (1998).
39 J. Imai, N. Ide, S. Nagae, T. Moriguchi, H. Matsuura, Y. Itakura. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Plant. Med. 60(5), 417-420 (1994).   DOI
40 B. Halliwell, R. Aeschbach, J. Loliger, O. I. Aruoma. The characterization of antioxidants. Food Chem. Toxicol. 33(7), 601-617 (1995).   DOI
41 M. R. Hyun, Y. S. Lee, Y. H. Park. Antioxidative Activity and Flavonoid Content of Chrysanthemum zawadskii Flowers. Kor. J. Hort. Sci. Technol. 29(1), 68-73 (2011).
42 K. S. Woo, J. S. Yu, I. G. Hwang, Y. R. Lee, C. H. Lee, H. S. Yoon, J. S. Lee, H. S. Jeon. Antioxidative Activity of Volatile Compounds in Flower of Chrysanthemum indicum, C. morifolium, and C. zawadskii. J Korean Soc Food Sci Nutr. 37(6), 805-809 (2008).   DOI
43 H. J. Chung, I. S. Jeon. Antioxidative activities of methanol extracts from different parts of Chrysanthemum zawadskii. Kor. J. Food Preserv. 18, 739-745 (2011).   DOI
44 Y. Y. Kim, S. Y. Lee, D. S. Yim. Biological activities of linarin Chrysanthemum zawadskii var. latilobum. Yakhak Hoeji. 45, 604-610 (2001).
45 D. H. Won, K. W. Ha. Medicinal Plants. Ministry of Food and Drug safety. p. 72 (1997).
46 Y. Y. Kim, S. Y. Lee, D. S. Yim. Biological activities of linarin from Chrysanthemum zawadskii var. latilobum. Yakhak Hoeji. 45, 604-610 (2001).
47 D. S. Jang, K. H. Park, S. W. Choi, S. H. Nam M. S. Yang. AntibacterialSubstances of the Flower of Chrysanthemum zawadsRill Herbich var. latilobum Kitamurs. Agri cultural Chemistry and Biotechnology. 40(1), 85-88 (1997).
48 J. Y. Han, Y. H. Kim, J. H. Sung, Y. R. Um, Y. Lee, J. S. Lee. Suppressive Effects of Chrysanthemum zawadskii var. latilobum Flower Extracts on Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression. J Korean Soc Food Sci Nutr. 38(12), 1685-1690 (2009).   DOI