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http://dx.doi.org/10.12925/jkocs.2016.33.3.435

Antioxidative Effect of Ethanol Extract on Arctium lappa root in Streptozotocin Induced Diabetic Rats  

Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.33, no.3, 2016 , pp. 435-440 More about this Journal
Abstract
This study was carried to investigate the antioxidative effect of ethanol extract of Arctium lappa(Al) root in Streptozotocin(STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45mg/kg.body wight(b.w) dissolved in citrate buffer. The ethanol extract of Al root was orally administrated once a day for 7 days at a dose of 1,000mg/kg.b.w. The contents of malondialdehyde(MDA) and activities of catalase (CAT), glutathione peroxidase(GSH-Px) were significantly decreased(p<0.05) in Al treated group compared to the those of STZ-control group. The content of glutathione(GSH) and activity of glutathione-s-transferase(GST) was significantly increased(p<0.05). These results indicated that ethanol extract of Al root would have antioxidative effect in STZ-induced diabetic rats.
Keywords
ethanol extract of Arctium lappa (Al) root; streptozotocin; antioxidative effect;
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