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http://dx.doi.org/10.12925/jkocs.2015.32.3.536

A study on the formation and Ostwald ripening stability of nanoemulsion with various emulsifiers  

Park, Eun-Jeong (Department of Food Science and Technology, College of Agriculture and Life Science, Chungnam National University)
Lee, Eui-Seok (Department of Food Science and Technology, College of Agriculture and Life Science, Chungnam National University)
Hong, Soon-Taek (Department of Food Science and Technology, College of Agriculture and Life Science, Chungnam National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.32, no.3, 2015 , pp. 536-545 More about this Journal
Abstract
This study aimed to investigate the effect of various emulsifiers on the formation of nanoemulsions and their stability properties. MCT (medium chain triglyceride) nanoemulsions were prepared (10 wt% oil, 10 wt% emulsifiers, 20 mM bis-tris, pH 7) with emulsifier such as Tween 20 (Polyoxyethylene(20) sorbitan monolaurate), Almax 3800 (Sorbitan monooleate), soy lecithin, and SSL (sodium stearoyl lactylate) and changes in fat globule size with respect to storage period and stability properties by Turbiscan were investigated. In case of control nanoemulsion with 10 wt% Tween 20, the initial fat globule size was 89.0 nm and 113.4 nm after 28 day of storage and this large increase (ca. 24 nm) was thought to be caused by Ostwald ripening. When Tween 20 was partially replaced with Almax 3800, lecithin and SSL in nanoemulsions, their physicochemical properties (i.e., fat globule size and stability) were changed accordingly. In general, the intial fat globule size was decreased with increasing the concentration of the emulsifiers and the stability against Ostwald ripening increased. The most stable nanoemulsions against Ostwald ripening could be prepared with emulsifiers of Tween 20 and Almax 3800 or lecithin in the ratio of 6:4 (wt%), which was verified with Ostwald ripening rate (${\omega}$). In addition, the emulsion stability by Turbiscan was observed to be consistent with results of changes in fat globule size with storage period.
Keywords
Nanoemulsion; Ostwald ripening; Fat globule size; Turbiscan;
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1 Y. Li, S. L. Maux, H. Xiao, and D. J. McClements, Emulsion-based delivery systems for tributyrin, a potential colon cancer preventative agent. J. Agr. Food Chem., 57(19), 9243(2009).   DOI
2 S. S. Lim, M. Y. Baik, E. A. Decker, L. Henson, L. M. Popplewell, D. J. McClements, and S. J. Choi. Stabilization of orange oil-in-water emulsions: A new role for ester gum as an ostwald ripening inhibitor. Food Chem., 128(4), 1023(2011).   DOI
3 S. Mun, and D. J. McClements, Influence of interfacial characteristics on ostwald ripening in hydrocarbon oil-in-water emulsions, Langmuir, 22(4), 1551(2006).   DOI
4 D. J. McClements a, "Food emulsions: principles, practices, and techniques", 2nd ed., p 333-335, CRC press, Florida, USA(2005).
5 X. Xin, H. Zhang, G. Xu, Y. Tan, J. Zhang, and X. Lv. Influence of CTAB and SDS on the properties of oil-in-water nano-emulsion with paraffin and span 20/Tween 20, Colloid Surface A., 418, 60(2013).   DOI
6 T. Aoyama, N. Nosaka, and M. Kasai, Research on the nutritional characteristics of medium chain fatty acids, J. Med Invest., 54(3,4), 385(2007).   DOI
7 T. J. Wooster, H. F. Andrews, and P. Sanguansri, Nanoemulsions, U. S. Patent, 20100305218 (2010).
8 D. Allende, A. Cambiella, J. M. Benito, C. Pazos, and J. Coca, Destabilization enhanced centrifugation of metalworking oil-in-water emulsions: Effect of demulsifying agents, Chem. Eng. Technol., 317(7), 1007(2008).
9 J. Weiss, N. Herrmann, and D. J. McClements, Ostwald ripening of hydrocarbon emulsion droplets in surfactant solutions, Langmuir, 15(20), 6652(1999).   DOI
10 P. Taylor, Ostwald ripening in emulsions, Adv. Colloid Interfac., 75(2), 107(1998).   DOI
11 O. Mengual, G. Meunier, I Cayre, K. Puech, and P. Snabre, Turbiscan MA 2000: multiple light scattering measurement for concentrated emulsion and suspension instability analysis. Talanta. 50(2), 445(1999).   DOI
12 A. H. Saberi, Y. Fang, and D. J. McClements, Effect of glycerol on formation, stability, and properties of vitamin-E enriched nanoemulsions produced using spontaneous emulsification. J. Colloid Interf. Sci., 411(1), 105(2013).   DOI
13 L. Mao, D. Xu, J. Yang, F. Yuan, Y. Gao, and J. Zhao, Effects of small and large molecule emulsifiers on the characteristics of ${\beta}$-carotene nanoemulsions prepared by high pressure homogenization, Food Technol. Biotechnol., 47(3), 336(2009).
14 D. J. McClements b, "Food emulsions: principles, practices, and techniques", 2nd ed., p 131-133, CRC press, Florida(2005).
15 S. Rebolleda, M. Teresa, J. M. Benito, S. Beltan, I. Escudero, and M. L. Gonzalez San-Jose, Formulation and characterisation of wheat bran oil-in-water nanoemulsions. Food Chem., 167. 16(2015).   DOI
16 M. M. Affandi, T. Julianto, and A. Majeed, Development and stability evaluation of astaxanthin nanoemulsion, Asian J. Pharm. Clin. Res., 4(1), 142(2011).
17 R. J. Whitehurst, "Food Emulsifiers in Food Technology", 1st ed. p 206-225, Blackwell publishing. Oxford(2004).
18 J. Weiss, C. Canceliere, and D. J. McClements, Mass transport phenomena in oil-in-water emulsions containing surfactant micelles: Ostwald ripening. Langmuir, 16(17), 6833(2000).   DOI
19 T. G. Mason, J. N. Wilking, K. Meleson, C. B. Chang, and S. M. Graves, Nanoemulsions: formation, structure, and physical properties, J. Phys-Condens Mat., 18(41), R635(2006).
20 D. J. Mcclements, and J. Rao, Food-grade Nanoemulsions: formation, fabrication, properties, performance, biological fate, and potential toxicity, Crit. Rev. Food Sci., 51(4), 285(2011).   DOI
21 C. Solans, P. Izquierdo, J. Nolla, N. Azemar, and M. J. Garcia-Celma, Nano-emulsions, Curr. Opin. Colloid In., 10(3-4), 102(2005).   DOI
22 D. J. McClements, Nanoemulsions versus Microemulsions: terminology, differences, and similarities, Soft Matter, 8, 1719(2012).   DOI
23 K. Ahmed, Y. Li, D. J. McClements, and H. Xiao, Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties, Food Chem., 132(2), 799(2012).   DOI
24 N. Anton, J. Benoit, and P. Saulnier, Design and production of nanoparticles formulated from nano-emulsion templates-A review, J. Control Release, 128(3), 185(2008).   DOI
25 P. Izquierdo, J. Esquena, T. F. Tadros, C. Dederen, M. J. Garcia, N. Azemar, and C. Solans. Formation and stability of nano-emulsions prepared using the phase inversion temperature method. Langmuir. 18(1), 26(2002).   DOI
26 J. W. Tim, G. Matt, and S. Peerasak, Impact of oil type on nanoemulsion formation and Ostwald ripening stability. Langmuir, 24(22), 12758(2008).   DOI