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http://dx.doi.org/10.12925/jkocs.2015.32.2.260

Physiological Activities of Cudrania tricuspidata Extracts on the Skin  

Choi, Hak Joo (Traditional and Biomedical Research Center (TBRC), Daejeon University)
Kim, Cheong Taek (RNS, Ltd.)
Do, Min Yeon (Goseong Agricultural Technology Center)
Rang, Moon Jeong (Department of Pharmaceutical Engineering, Pai Chai University)
Publication Information
Journal of the Korean Applied Science and Technology / v.32, no.2, 2015 , pp. 260-274 More about this Journal
Abstract
This paper has shown the experimental results about the physiological activities of water-, ethanol-, ethyl acetate-soluble fractions from ethanolic extracts of leaves, stems and roots of Cudrania tricuspidata on the skin, which has been used for a long time as a traditional herb medicine in Korea and China. The effects of these fractions on the secretion of nitric oxide and cytokines from macrophage(RAW 264.7 cell) exhibited that the ethyl acetate and water fractions from leaves inhibited the release of nitric oxide, all fractions inhibited thoses of inflammatory cytokine $IL-1{\alpha}$, and the ethyl acetate fractions of leaves, stems and roots inhibited thoses of inflammatory cytokine IL-6. The only ethylacetate fraction of leaves demonstrated significantly the reduction of melanin synthesis in melanoma cells. In order to evaluate the efficacy of collagen synthesis, the treatment with extracts on the human normal fibroblast cell(CCD-986sk cell) resulted in finding that the water fractions of leaves, stems and roots and the ethanol fractions of leaves and stems showed the increased synthesis of collagen.
Keywords
Cudrania tricuspidata; Physiological Activities; Anti-inflammation; Cytokines; Melanogenesis; Collagen Synthesis;
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Times Cited By KSCI : 21  (Citation Analysis)
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