Browse > Article
http://dx.doi.org/10.12925/jkocs.2015.32.2.260

Physiological Activities of Cudrania tricuspidata Extracts on the Skin  

Choi, Hak Joo (Traditional and Biomedical Research Center (TBRC), Daejeon University)
Kim, Cheong Taek (RNS, Ltd.)
Do, Min Yeon (Goseong Agricultural Technology Center)
Rang, Moon Jeong (Department of Pharmaceutical Engineering, Pai Chai University)
Publication Information
Journal of the Korean Applied Science and Technology / v.32, no.2, 2015 , pp. 260-274 More about this Journal
Abstract
This paper has shown the experimental results about the physiological activities of water-, ethanol-, ethyl acetate-soluble fractions from ethanolic extracts of leaves, stems and roots of Cudrania tricuspidata on the skin, which has been used for a long time as a traditional herb medicine in Korea and China. The effects of these fractions on the secretion of nitric oxide and cytokines from macrophage(RAW 264.7 cell) exhibited that the ethyl acetate and water fractions from leaves inhibited the release of nitric oxide, all fractions inhibited thoses of inflammatory cytokine $IL-1{\alpha}$, and the ethyl acetate fractions of leaves, stems and roots inhibited thoses of inflammatory cytokine IL-6. The only ethylacetate fraction of leaves demonstrated significantly the reduction of melanin synthesis in melanoma cells. In order to evaluate the efficacy of collagen synthesis, the treatment with extracts on the human normal fibroblast cell(CCD-986sk cell) resulted in finding that the water fractions of leaves, stems and roots and the ethanol fractions of leaves and stems showed the increased synthesis of collagen.
Keywords
Cudrania tricuspidata; Physiological Activities; Anti-inflammation; Cytokines; Melanogenesis; Collagen Synthesis;
Citations & Related Records
Times Cited By KSCI : 21  (Citation Analysis)
연도 인용수 순위
1 Y. N. Lee, New Flora of Korea, I, p.246-247, Kyo-Hak Publishing Co. Ltd. (2006).
2 J. S. Kim and T. Y Kim, Woody Plants of Korea, p.142, Dolbegae(2011).
3 Doopedia(Doosan Encyclopedia), Cudrania tricuspidata, Doosan Corporation, Available From http://www.doopedia.co.kr/doopedia/master/master.do?_method=view&MAS_ IDX=101013000831679 (accessed March 24, 2015).
4 H. J. Choi, C. T. Kim, M. Y. Do and M. J. Rang, Physiological Activities of Cudrania tricuspidata Extracts (Part 1), J, Korea Academia-Industrial Cooperation Soc., 14(8), 3911(2013).
5 Heo-Jun, Translation Dongui Bogam, p.1972, Bub-In Culture Co.(1999).
6 C. M. Kim, Translation Encyclopedia of Oriental, p.4166, p.3357, p.3582, Herbal Medicine, Jeong-Dam (2004).
7 J. C. Park, H. S. Young and J. S. Choi, Constituents of Cudrania tricuspidata in Korea, YAKHAK HOEJI, 36(1), 40 (1992).
8 S. H. Kim, N. J. Kim, J. S. Choi and J. C. Park, Determination of Flavonoid by HPLC and Biological Activities from the Leaves of Cudrania tricuspidata Bureau, J. Korean Soc, Food Sci. Nutr., 22(1), 68 (1993).
9 Z. P. Zheng, H. Y. Tan, J. Chen and M. F. Wang, Characterization of Tyrosinase Inhibitors in the Twigs of Cudrania tricuspidata and Their Structure-Activity Relationship Study, Fitoterapia, 84, 242 (2013).   DOI
10 I. K. Lee, K. S. Song, C. J. Kim, H. M. Kim, G. T. Oh and I. D. Yoo, Tumor Cell Growth Inhibition and Antioxydative Activity of Flavonoids from the Stem Bark of Cudrania tricuspidata, J, Korean Soc. Appl. Biol. Chem., 37(2), 105 (1994).
11 I. K. Lee, C. J. Kim, K. S. Song, H, M. Kim, H. Koshino, M. Uramoto, and I. D. Yoo, Cytotoxic Benzyl Dihydroflavonols from Cudrania tricuspidata, Phytochemistry, 41(1), 213 (1996).   DOI
12 Y. S. Zou, A. J. Hou, G. F. Zhu, Y. F. Chen, H. D. Sun and Q. S. Zhao, Cytotoxic isoprenylated xanthones from Cudrania tricuspidata, Bioorganic & Medicinal Chemistry, 12, 1947 (2004).   DOI
13 B. W. Lee, J. H. Lee, S. T. Lee, H. S. Lee, W. S. Lee, T. S. Jeong and K. H. Park, Antioxidant and Cytotoxic Acvities of Xnthones from Cudrania tricuspidata, Bioorganic & Medicinal Chemistry, 15, 5548 (2005).   DOI
14 Y, K. Yoon, S. E. Lee, D. J. Lee, M. C. Rho, J. S. Sung, C. B. Park and Y. J. Jang, Anti-cancer Activity of Korean Local Plant Extracts Inducing Apoptosis in Various Carcinoma Cells, Natural Product Sciences, 40(1), 6 (2009).
15 S. R. Choi, D. H. You, I. Jang, M. S. Ahn, E. J. Song, S. Y. Seo, M. K. Choi, Y. S. Kim, M. K. Kim and D. G. Choi, Cytotoxicity of Methanol Extracts from Cudrania tricuspidata Bureau, Korean J. Medicinal Crop Sci., 20(3), 153 (2012).   DOI
16 B. W. Lee, N. S. Kang and K. H. Park , Isolation of Antibacterial Prenylated Flavonoids from Cudrania tricuspidata, J, Korean Soc. Appl. Biol. Chem., 47(2), 270 (2004).
17 Y. C. Kim, J. Hur, D. H. Sohn and H. S. Kim, Antibacterial Compounds of the Root Barks of Cudrania tricuspidata, Journal of Pharmacognosy, 39(3), 246 (2008).
18 S. R. Choi, D. H. You, J. Y. Kim, C. B. Park, D. H. Kim, and J. Ryu, Antioxidant Activity of Methanol Extracts from Cudrania tricuspidata Bureau According to Harvesting Parts and Time, Korean J Medicinal Crop Sci., 17, 115 (2009).
19 J. Y. Cha, H. J. Kim, C. H. Chung and Y. S. Cho, Antioxidative Activities and Contents of Polyphenolic Compound of Cudrania tricuspidata, ]. Korean Soc. Food Sci. Nutr., 28(6), 1310 (1999).
20 J. Y. Cha and Y. S. Cho, Antioxidative Activity of Extracts from Fruit of Curdrania tricuspidata, J, Korean Soc, Food Sci, Nutr,, 30(3), 547 (2001).
21 C. H. Jeong , G. N. Choi, J. H. Kim, J. H. Kwak, H. J. Heo, K. H. Shim, B. R. Cho, Y. I. Bae and J. S. Choi, Jine-Shang. In vitro Antioxidative Activities and Phenolic Composition of Hot Water Extract from Different Parts of Cudrania tricuspidata, J, Food Sci, Nutr., 14(4), 283 (2009).   DOI
22 K. S. Youn and J. W. Kim, Antioxidant and Angiotensin Converting Enzyme I Inhibitory Activities of Extracts from Mulberry (Cudrania tricuspidata) Fruit subjected to Different Drying Methods, J, Korean Soc, Food Sci. Nutr., 41(10), 1388 (2012).   DOI
23 J. Y. Cha, H. J. Kim and Y. S. Cho, Effects of Water-Soluble Extract from Leaves of Morus alba and Cudrania tricuspidata on the Lipid Peroxidation in Tissues, J, Korean Soc, Food Sci. Nutr., 25(3), 631 (2000).
24 J. H. Park, K. W. Lee, K. S. Sung, S. S. Kim, K. D. Cho, B. H. Lee and C. K. Han, Effect of Diets with Job's Tears and Cudrania tricuspidata Leaf Mixed-powder Supplements on Body Fat and Serum Lipid, J, Korean Soc, Food Sci. Nutr,, 41(9), 943 (2012).   DOI
25 W. Y. Park, J. S. Ro and K. S. Lee, Hypoglycemic Effect of Cudrania tricuspidata Root Bark, Kor. J. Pharmacogn. 32(3), 248 (2001).
26 K. B. Lee, K. S. Song, E. H. Moon, J. L. Lee and Y. C. Yoo, Adjuvant Activity of Cudrania tricuspidata Water Extracts to Enhance Antigen Specific Humoral and Cellular Immune, J, Korean Soc. Appl. Biol. Chem., 52(2), 234 (2009).   DOI
27 O. K. Kim, J. N. Ho, D. E. Nam, W. J. Jun, K. T. Hwang, J. E. Kang, O. S. Chae, and J. M. Lee, Hepatoprotective Effect of Curdrania tricuspidata Extracts against Oxidative Damage, J. Korean Soc. Food Sci. Nutr., 41(1),7 (2012).   DOI
28 D. H. Kwon, M. B. Kim, D. Y. Yoon, Y. H. Lee, J. W. Kim, H. G. Lee, I. S. Cha, J. S. Lim. and Y. K. Choe, Screening of Plant Resources of Anti-viral Activity, Korean J, Medicinal Crop Sci., 11(1), 24 (2003).
29 K. W. Lee, K. S. Sung, S. S. Kim, O. H. Lee, B. H. Lee and C. K. Han, Effects of Cucurbita moschata, Adlay Seed and Cudrania tricuspidata Leaf Mixed-powder Diet Supplements on the Visceral Fat, Fecal Amount and Serum Lipid Levels of the Rats on a High-Fat Diet, Korean J. Food & Nutr., 25(4), 990 (2012).   DOI
30 J. H. Choi, H. S. Han and Y. J. Lee, Dong-Young, The Inhibitory Effect of Cudraniae Lignum on the Collageninduced Arthritis in Mice, Kor. J. Herbology, 24(3), 121 (2009).
31 D. E. Nam, O. K, Kim and J. M. Lee, Jeongmin, Therapeutic Effects of Curdrania tricuspidata Leaf Extract on Osteoarthritis, Korean J. Food & Nutr., 42(5), 697 (2013).   DOI
32 J. C. Park and H. Y. Lee, Screening of Medicinal Plants on the Anti-inflammatory Effect and Active Component, Korean J. Food & Nutr., 25(3), 523 (1996).
33 Y. M. Kim, Cudrania tricuspidata Suppresses Mast Cell-Mediated Allergic Response In Vitro and In Vivo, YAKHAK HOEJI, 56(1), 26 (2012).
34 O. K. Kim, J. N. Ho, D. E. Nam, W. J. Jun and J. M. Lee, Anti-wrinkle Activity of a Curdrania tricuspidata Extract on Ultraviolet-induced Photoaging, J. Korean Soc, Food Sci, Nutr., 42(4), 608 (2013).   DOI
35 S. S. Oh, E. J. Seo, H. Y. Kim, Y. B. Ryu, J. W. Lee, S. W. Gal and K. H. Park, Tyrosinase Inhibitory Xanthones from Cudrania tricuspidata, Journal of Life Science, 17(4), 476 (2007).   DOI
36 H. J. Lee, J. R. Do, J. H. Kwon and H. K. Kim, Physiological Activities of Extracts from Different Parts of Cudrania tricuspidata, J. Korean Soc, Food Sci, Nutr., 40(7), 942 (2011).   DOI
37 Z. Wang, P. Zheng, H. Y. Tan, J. Chen and M. F. Wang, Characterization of Tyrosinase Inhibitors in the Twigs of Cudrania tricuspidata and Their Structure-Activity Relationship study, Fitoterapia, 84, 242 (2013).   DOI
38 M. J. Rang, Anti-inflammatory and Anti-allergic Effects of Herbal Extracts on Atopic Dermatitis (Part 2), J. of the Korean Oil Chemists' Soc., 30(1), 75 (2013).
39 D. Mosser and J. P. Edwards, Exploring the Full Spectrum of Macrophage Activation, Nature Reviews Immunology, 8, 958 (2008).   DOI
40 M. J. Rang, Anti-inflammatory and Anti-allergic Effects of Herbal Extracts on Atopic Dermatitis (Part I), J. of the Korean Oil Chemists' Soc., 28(1), 75 (2011).
41 J. Y. Min and Y. K. Park, Effect of Dipsaci Radix Water Extract on LPS-induced Inflammatory Response in RAW264.7 Mouse Macrophages, Kor. J. Herbology, 24(4), 189 (2009).
42 Y. S. Kang, K. Y. Kyeong, M. J. Rang, D. H. Bae, Y. G. Lee, W. G. Cho, S. G. Choi and S. G. Han, Science of Cosmetics and Household Poroducts (I), p. 331, Shin Kwang Publishing Co. Ltd.(2008).
43 S. A. Park, H. M. Lee, J. H. Ha, S. H., Jeon and S. N. Park, Inhibitory Effects of Dendropanax Marbifera Leaf Extracts on Malanogenesis through Down-regulation of Tyrosinase and TRP-2, Appl. Chem. Eng., 25(5), 468 (2014).   DOI
44 S. H. Kim, N. J. Kim, J. S. Choi and J. C. Park, Determination of Flavonoid by HPLC and Biological Activities from the Leaves of Cudrania tricuspidata Bureau, J. Korean Soc, Food Sci. Nutr., 22(1), 68 (1993).
45 J. C. Park, J. S. Choi and J. W. Choi, Effects of the Fractions from the Leaves, Fruits, Stems and Roots of Cudrania tricuspidata and Flavonoids on Lipid Peroxidation, Kor. J. Pharmacogn. 26(4), 377 (1995).
46 S. Ito, A Chemist's View of Melanogenesis, Pigment Cell Res., 16, 230 (2003).   DOI
47 E. S. Yang, R. H. Hong and S. M. Kang, The Effect of Genistein on the Proliferation and Type I pN Collagen Synthesis in Aged Normal Human Fibroblasts, Kor. J. Microbiol. Biotechnol., 35(4), 316 (2007).
48 O. K. Kim, J. N. Ho, D. E. Nam, W. J. Jun and J. M. Lee, Anti-wrinkle Activity of a Curdrania tricuspidata Extract on Ultraviolet-induced Photoaging, J. Korean Soc, Food Sci, Nutr., 42(4), 608 (2013).   DOI