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http://dx.doi.org/10.12925/jkocs.2015.32.2.226

Antidiabetic Effect of ethanol extract of Forsythia Koreana in Streptozotocin-Induced Diabetic Rat  

Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.32, no.2, 2015 , pp. 226-231 More about this Journal
Abstract
This study was carried to investigate the antidiabetic effect of ethanol extract in Streptozotocin(STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45mg/kg dissolved in citrate buffer. The ethanol extract of Forsythia Koreana(F.K) was orally administrated once a day for 7 days at a dose of 1,000mg/kg. The contents of serum glucose, triglyceride(TG), total cholesterol were significantly decreased in F.K treated group compared to the those of STZ-control group. The content of hepatic glycogen and activity of glucokinase(GK) were significantly increased, and activity of glucose-6-phoshatase(G-6-Pase) was significantly decreased in F.K treated group compared to the those of STZ-control group, but activity of glucose-6-phosphate dehydrogenase(G-6-PDH) was not significantly increased, These results indicated that ethanol extract of F.K would have antidiabetic effect in STZ-induced diabetic rats.
Keywords
streptozotocin; triglyceride; total cholesterol; antidiabetic effects; Forsythia Koreana(F.K);
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Times Cited By KSCI : 3  (Citation Analysis)
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