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http://dx.doi.org/10.12925/jkocs.2015.32.1.157

Study of stabilizing and efficacy evaluation in human of Oleanoic acid with poly-glyceryl nano emulsion system  

Han, Sang-Keun (Department of Industrial Engineering Chemistry, College of Engineering, Chungbuk National University)
Lee, Dong-Kyu (Department of Industrial Engineering Chemistry, College of Engineering, Chungbuk National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.32, no.1, 2015 , pp. 157-164 More about this Journal
Abstract
Oleanolic acid is known as which anti-cancer, anti-sinhaeng angiogenic, anti-inflammatory, antioxidant and anti-wrinkle effects. We focused on the antioxidant activity of oleanolic acid was separated from the natural plant and It was confirmed that the whitening effect. In this study, oleanolic acid was stabilized by polyglyceryl surfactant which from natural origin with only a simple stirring operation, and compared with lecithin liposome that was manufactured with high cost facility. The transdermal transition rate of 0.4% oleanolic acid polyglyceryl nanoemulsion was 95%, and it was simillar with lecithin liposome of 92%. 65% of 3hr transdermal transition rate of polyglyceryl nanoemulsion indicate charistiristcs of quick release, compared with 45% of lecithin liposome's 3hr transdermal transition rate. In the in-vivo clinical trial test, polyglyceryl nanoemulsion of 0.4% oleanolic acid was higher 25% in 2nd week, 58% in 4th and 8th weeks than non-added oleanolic acid emulsion.
Keywords
Oleanolic acid; Whitening effect; lecithin liposome; lpolyglyceryl nonoemulsion;
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Times Cited By KSCI : 2  (Citation Analysis)
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