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http://dx.doi.org/10.12925/jkocs.2014.31.4.653

Effect of natural plant extract (Abelmo) on action mechanism and hair growth activities in C57BL/6 mice  

Park, Sang-Oh (Institute of Animal Resources, Kangwon National University)
Park, Byung-Sung (Devision of Applied Animal Science, Kangwon National University)
Noh, Ga-Yeong (NJY Life Science)
Publication Information
Journal of the Korean Applied Science and Technology / v.31, no.4, 2014 , pp. 653-662 More about this Journal
Abstract
This study was determined the hair growth effect and mode of action of a complex extract (abelmo), extracted from various natural plants including Acorus calamus var. angustatus. 30 six-week old C57BL/6 mice were randomly assigned into three treatment groups with ten mice per treatment group repeatedly. The treatment group is a control group, and was classified into saline-applied, minoxidil 5%-applied, and abelmo-applied groups. Hair growth started from the abelmo-applied and minoxidil 5% -applied groups on the 9th day, compared to the saline-applied group. Hair growth rate was 17.06% and 19.15% in those two groups, respectively, and the abelmo-applied group's hair growth rate was higher. The density, length and thickness of hair were significantly higher in the order of abelmo-applied group, minoxidil 5%-applied group and saline-applied group on the 9th day, and hair root was strongly maintained in the abelmo-applied group. The density, length and thickness of hair in the abelmo-applied group were significantly higher by 599.8, 122.2 and 181.8% on the 9th day compared to the saline-applied group, and 166.7, 171.4 and 200.2% on the 12th day, and 136.6, 216.9 and 180.7%, respectively on the 15th day. As for hair follicle and the length of hair shaft from the dosal skin histopathology manifestation, the abelmo-applied group was more excellent than the saline-applied group and minoxidil 5%-applied group. This result actually confirmed the fact that abelmo promotes hair growth and strongly maintains hair root simultaneously.
Keywords
Abelmo; hair growth rate; density; length; thickness; skin; histopathology;
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Times Cited By KSCI : 4  (Citation Analysis)
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