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http://dx.doi.org/10.12925/jkocs.2013.30.4.602

Nanoemulsions containing Vitamin E acetate prepared by PIC(phase inversion composition) methods: Factors affecting droplet sizes  

Kim, Eun-Hee (Basic Medicine Department, College of Medical Science, Jeonju University)
Cho, Wan-Goo (Basic Medicine Department, College of Medical Science, Jeonju University)
Publication Information
Journal of the Korean Applied Science and Technology / v.30, no.4, 2013 , pp. 602-611 More about this Journal
Abstract
We have investigated the influence of system composition and preparation conditions on the particle size of vitamin E acetate (VE)-loaded nanoemulsions prepared by PIC(phase inversion composition) emulsification. This method relies on the formation of very fine oil droplets when water is added to oil/surfactant mixture. The oil-to-emulsion ratio content was kept constant (5 wt.%) while the surfactant-to-oil ratio (%SOR) was varied from 50 to 200 %. Oil phase composition (vitamin E to medium chain ester ratio, %VOR) had an effect on particle size, with the smallest droplets being formed below 60 % of VOR. Food-grade non-ionic surfactants (Tween 80 and Span 80) were used as an emulsifier. The effect of f on the droplet size distribution has been studied. In our system, the droplet volume fraction, given by the oil volume fraction plus the surfactant volume fraction, was varied from 0.1 to 0.3. The droplet diameter remains less than 350 nm when O/S is fixed at 1:1. The droplet size increases gradually as the increasing the volume fraction. Particle size could also be reduced by increasing the temperature when water was added to oil/surfactant mixture. By optimizing system composition and homogenization conditions we were able to form VE-loaded nanoemulsions with small mean droplet diameters (d < 50 nm). The PIC emulsification method therefore has great potential for forming nanoemulsion-based delivery systems for food, personal care, and pharmaceutical applications.
Keywords
Foods; Nanoemulsion; PIC; Ostwald ripening; Cosmetics;
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1 A. Forgiarini, J. Esquena, C. Gonza, and C. Solans, Langmuir, 17, 2076 (2001).   DOI   ScienceOn
2 E. H. Kim and W. G. Cho, JDCTA, 7(11), 365 (2013).
3 P. Izquierdo, J. Feng, J. Esquena, T. F. Tadros, J. C. Dederen, M. J. Garcia, N. Azemar, and C. Solans, J. Colloid Interface Sci., 285, 388 (2005).   DOI   ScienceOn
4 M. Hessien, N. Singh, C. Kim, and E. Prouzet, Langmuir, 27 (2011) 2299.   DOI   ScienceOn
5 L. Wang, J. Dong, J. Chen, J. Eastoe, and X. Li, J. Colloid Interface Sci., 330, 443 (2009).   DOI   ScienceOn
6 D. Morales, J. M. Gutierrez, M. J. Garcia-Celma, and Y. C. Solans, Langmuir, 19, 7196 (2003).   DOI   ScienceOn
7 L. Yu, C. Li, J. Xu, J. C. Hao, and D. J. Sun, Langmuir, 28, 14547 (2012).   DOI   ScienceOn
8 S. Sahin and S. G. Sumnu, Physical Properties of Foods, Springer, New York, 2006.
9 J. Israelachvili, Intermolecular and Surface Forces, third ed., Academic Press, London, UK, 2011.
10 N. Anton and T. F. Vandamme, Int. J. Pharm., 377, 142 (2009).   DOI   ScienceOn
11 D. J. McClements, Soft Matter, 7, 2297 (2011).   DOI   ScienceOn
12 T. G. Mason, J. N. Wilking, K. Meleson, C. B. Chang, and S. M. Graves, J. Phys. Condens. Matter, 18, R635 (2006).   DOI   ScienceOn
13 D. J. McClements and J. Rao, Crit. Rev. Food Sci. Nutr., 51, 285 (2011).   DOI   ScienceOn
14 A. S. Kabalnov and E. D. Shchukin, Adv. Colloid Interface Sci., 38, 69 (1992).   DOI   ScienceOn
15 D. J. McClements, Food Emulsions: Principles, Practice, and Techniques, second ed., CRC Press, Boca Raton, 2005.
16 F. Ostertag, J. Weiss, and D. J. McClements, J. Colloid Interface Sci., 388, 95 (2012).   DOI   ScienceOn
17 Z. Cordero, D. Drogan, C. Weikert, and H. Boeing, Crit. Rev. Food Sci. Nutr., 50, 420 (2010).   DOI   ScienceOn
18 J. Feng, Z. Wang, J. Zhang, Z. Wang, and F. Liu, Colloids Surf. A, 339, 1 (2009).
19 D. J. McClements, E. A. Decker, and J. Weiss, J. Food Sci., 72, R109 (2007).   DOI   ScienceOn
20 C. Solans and I. Sole, Curr. Opin. Colloid Interface Sci., 17, 246 (2012).   DOI   ScienceOn
21 T. Tadros, P. Izquierdo, J. Esquena, and C. Solans, Adv. Colloid Interface Sci., 108-109, 303 (2004).   DOI   ScienceOn
22 N. Anton and T.F. Vandamme, Int. J. Pharm., 377, 142 (2009).   DOI   ScienceOn
23 D. J. McClements, Ther. Delivery, 3, 801 (2012).   DOI
24 D. J. McClements and J. Rao, Crit. Rev. Food Sci. Nutr., 51, 285 (2011).   DOI   ScienceOn
25 A. A. Date, N. Desai, R. Dixit, and M. Nagarsenker, Nanomedicine, 5, 1595 (2010).   DOI   ScienceOn
26 W. Somchue, W. Sermsri, J. Shiowatana, and A. Siripinyanond, Food Res. Int., 42, 909 (2009).   DOI   ScienceOn
27 J. H. Yoo, S. Shanmugam, P. Thapa, E. S. Lee, P. Balakrishnan, R. Baskaran, S. K. Yoon, H. G. Choi, C. S. Yong, B. K. Yoo, and K. Han, Arch. Pharmacal Res., 33, 417 (2010).   DOI   ScienceOn
28 C. M. Pey, A. Maestro, I. Sole, C. Gonzalez, C. Solans, and J. M. Gutierrez, Colloids Surf. A, 288, 144 (2006).   DOI   ScienceOn