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http://dx.doi.org/10.12925/jkocs.2013.30.3.394

Antidiabetic Study of ethanol extract on Ailanthi cortex radici  

Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.30, no.3, 2013 , pp. 394-399 More about this Journal
Abstract
This study was performed to investigate the antidiabetic study effect in ethanol extract of Ailanthicortex(A.C) radici in Streptozotocin(STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45mg/kg dissolved in citrate buffer. The ethanol extract of A.C radici was orally administrated once a day for 7 days at a dose of 500mg/kg. The content of serum glucose, triglyceride(T.G), total cholesterol were significantly decreased in treated group compared to the those of STZ-control group. The content of hepatic glycogen and activity of glucokinase(GK) were significantly increased in treated group compared to the those of STZ-control group. but activity of glucose-6-phosphate dehydrogenase(G-6-PDH) was significantly increased. These results indicated that ethanol extract of A.C would have antidiabetic effect in STZ-induced diabetic rats.
Keywords
streptozotocin; triglyceride; total cholesterol; antidiabetic effects; Ailanthicortex(A.C) radici;
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