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http://dx.doi.org/10.12925/jkocs.2011.28.3.8

Characteristics of L-Ascorbic Acid Encapsulated BGsome and its Stabilization Effect  

Hwang, Sue-Yun (Department of Applied Chemistry, Dongduk Women's University)
Jin, Byung-Suk (Department of Applied Chemistry, Dongduk Women's University)
Publication Information
Journal of the Korean Applied Science and Technology / v.28, no.3, 2011 , pp. 313-320 More about this Journal
Abstract
Encapsulation of L-ascorbic acid(AA) into BGsome was attempted to improve its stability. BGsome is a bio-compatible vesicular system prepared by dispersion of hydrated liquid crystalline phase formed through hydration of 1,3-butylene glycol(BG)-dissolved lecithin with an aqueous solution containing hydrophilic component. The characteristics of AA encapsulated BGsome, such as droplet size, surface charge, and solution appearance, was investigated. The concentration of AA solution had considerable effect on droplet size and surface charge of BGsome. Several tens nanometer droplet made by sonication treatment did not showed any change of size with storage time. Stability of AA was improved by encapsulation into BGsome, which was verified through DPPH test and HPLC assay.
Keywords
BGsome; L-ascorbic acid; 1,3-butylene glycol; hydrated liquid crystalline vesicle;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 G.Cevc and G.Blume, Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force, Biochim. Biophys. Acta, 1104, 226 (1992).   DOI   ScienceOn
2 G.Cevc, Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and trandermal drug delivery, Crit. Rev. Ther. Drug Carrier Syst., 13, 257 (1996)
3 B.S. Jin, S.M. Lee, and K.H.Lee, A study on the factors affecting entrapment efficiency and particle size of ethosomes, J. Kor. Ind. Eng. Chem, 17(2), 138 (2006).
4 H.J. Gwak, and B.S. Jin. Preparation and characterization of EGCG entrapped ethosome, J. Kor. Ind. Eng. Chem, 18(2), 130 (2007).
5 P. L. Honeywell-Nguyen, P.M. Frederik, P.H. Bomans, H.E. Jungin,ger, and J.A. Bouwstra, Trandermal delivery of pergolide from surfactant based elastic and rigid vesicles, Pharm. Res. 19, 991 (2002).   DOI   ScienceOn
6 M.A. Elsayed et al., Lipid vesicles for skin delivery of drugs : reviewing three decades of research, Int. J. Pharm., 332, 1 (2007)   DOI   ScienceOn
7 G.M. El Maghraby, A.C. Williams, and B.W. Barry, Interaction of surfactant and skin penetration enhancers with liposomes, Int. J. Pharm. 276, 143 (2004).   DOI
8 B.A. van den Bergh et al., Elasticity of vesicles affects hairless mouse skin structure and permeability, J. Cont. Rel. 62, 367(1999).   DOI   ScienceOn
9 P. L. Honeywell-Nguyen, J.A. Bouwstra, The in vitro transport of pergolide from surfactant based elastic vesicles through human skin, J. Cont. Rel. 86, 145 (2003).   DOI   ScienceOn
10 E. Touitou, N. Dayan, L. Bergelson, B.Godin, and M. Eliaz, Ethosomes - novel vesicular carriers for enhanced delivery : characterization and skin penetration properties, J. Cont. Rel. 65, 403 (2000).   DOI   ScienceOn
11 E. Touitou, B. Godin, and C. Weiss, Enhanced delivery of drugs into and across the skin by ethosomal carriers, Drug Dev. Res. 50, 406 (2000).   DOI   ScienceOn
12 M. Foldvari, A. Gesztes, M. Mezei, L. Cardinal, I. Kowalczyk, and M. Behl, Topical liposomal local anesthetics : design, optimization and evaluation of formulations, Drug Dev. Ind. Pharm. 19, 2499 (1993).   DOI   ScienceOn
13 M. N. Jones, The surface properties of phospholipid liposome systems and their characterization, Adv. in Colloid and Interface Science, 54, 93 (1995).   DOI
14 W.Yu, A.Zou, and R.Guo, Hydrotrope and hydrotrope-solubilization action of Vitamin C, Colloids and Surfaces, 167, 293 (2000).   DOI   ScienceOn
15 K.Makino, T.Yamada, M. Kimura, T. Oka, and H. Ohshima, Temerature and ionic strength induced conformational changes in the lipid head group region of liposomes, Biophys. Chem., 41, 175 (1991).   DOI   ScienceOn