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http://dx.doi.org/10.12925/jkocs.2011.28.3.2

Antidiabetic Metabolism Effect on the water Extract of $Cordyceps$ $Militalis$ in Streptozotocin-Induced Diabetic Rats  

Kim, Ok-Kyung (Department of Food and Nutrition, Dae Jin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.28, no.3, 2011 , pp. 267-272 More about this Journal
Abstract
This study was carried to investigate the antidiabetic metabolism effect of water extract $Cordyceps$ $Militalis$(C.M.) in Streptozotocin(STZ) induced diabetic rats. Diabetes were induced by intravenous injection of STZ at a dose of 42mg/kg,b.w. dissolved in citrate buffer. The water extract of C.M. was orally administrated once a day for 7 days at a dose of 500mg/kg,b.w(body weight). or 1,000mg/kg.b.w. The content serum glucose was significantly decreased in C.M. treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(G-6-PDH), glucokinase(GK) were significantly increased, but activity of glucose-6-phoshatase(G-6-Pase) was significantly decreased in C.M. treated group compared to the those of STZ-control group. These results indicated that water extract of C.M. would have antidiabetic metabolism effect in STZ-induced diabetic rats.
Keywords
streptozotocin; antidiabetic metabolism effect; Cordyceps Militalis;
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