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http://dx.doi.org/10.12925/jkocs.2011.28.3.1

Synthesis and Application of Caffeic Acid Methoxy Polyethylene Glycol Ester  

Lee, Hyun-Gi (Department of Engineering Chemistry, College of Engineering Chungbuk National University Chemistry)
Jeong, Noh-Hee (Department of Engineering Chemistry, College of Engineering Chungbuk National University Chemistry)
Publication Information
Journal of the Korean Applied Science and Technology / v.28, no.3, 2011 , pp. 259-266 More about this Journal
Abstract
Caffeic acid is a kind of phytochemicals occurred in coffee, which is worked as a carcinogenesis restrainer and antioxidants on the human body. In this study, as one type of caffeic acid derivatives, methoxypolyethylene glycol caffeate(MPC) was synthesized by the esterification between caffeic acid and methoxypolyethylene glycol with N,N'-dicyclohexyl carbodiimide, 4-dimethylamino pyridine. The synthesized product was confirmed by using FT-IR and $^1H$-NMR, thin-layer chromatography. And these compound was investigated as antioxidant, Tyrosinase hindrance and skin moisturizers. In the free radical scavenging study, antioxidant effect of MPC was averagely high than the red ginseng extract that be used as a natural antioxidants. The result of Tyrosinase anti-activity test was better than embryo bud of rice extract at low concentration. At the iNOS anti-activity tested by using Raw 264.7 cell, and confirmed anti-inflammatory function. For the MPC handled with sodium lauryl sulfate, was tested for the skin moisture content and skin moisture loss.
Keywords
Caffeic acid; Polyethylene gylcol; Antioxidant activity; tyrosinase activity; iNOS activity;
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Times Cited By KSCI : 4  (Citation Analysis)
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