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http://dx.doi.org/10.12925/jkocs.2011.28.2.9

Synthesis of Trifoliate Orange Extract Having Anti inflammation Activities  

Kim, Duck-Sool (Department of biomedical Engineering, Tongmyong University)
Roh, Eon-Joo (Department of Chemical Engineering, Changwon National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.28, no.2, 2011 , pp. 196-202 More about this Journal
Abstract
Coumarin derivatives were shown to possess valuable pharmacological properties such as anticancer/anti carcinogenic, anti-inflammatory, anti helicobacter, anti genotoxic, neuroprotective and dietary effect. In this study, novel coumarin derivatives structurally related to 7-geranyloxycoumarin were effectively synthesised in good yields by $Cs_2CO_3$/acetonitrile in mild condition. The synthesis of geranyloxycoumarin derivatives in weak base($Na_2CO_3$, $K_2CO_3$, $Cs_2CO_3$ etc)/$CH_3CN$ at room temperature obtained in good yield. On the other hand, the reaction of geranyloxycoumarin formation in strong base(NaOH, KOH, CsOH etc)/$CH_3CN$ at reflux condition obtained in low yield.
Keywords
Geranyloxycoumarin; Anti-inflammatory; Dietary;
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Times Cited By KSCI : 3  (Citation Analysis)
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