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http://dx.doi.org/10.12925/jkocs.2008.25.1.10

Antidiabetic and Antioxidative Effects of Lycii fructus in Streptozotocin-Induced Diabetic Rats  

Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.25, no.1, 2008 , pp. 73-82 More about this Journal
Abstract
This study was done to investigate the antidiabetic and antioxidant effects of Lycii fructus in Streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose 45mg/kg.b.w. dissolved in citrate buffer(pH4.5). The ethanol extract of Lycii fructus was orally administrated once a day for 7 days. The contents of serum glucose, total cholesterol were significantly decreaed (p<0.05) in Lycii fructus treated group compared to the those of STZ-control group, also content of Triglyceride (TG), Altherogenic index (AI) were decreased, but not statistically significant. But high density lipoprotein (HDL)-cholesterol and HDL-cholesterol/total cholesterol ratio (HTR) were increased in Lycii fructus treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(G-6PDH), glutathione-s-transferase(GST), superoxide dismutase(SOD) were significantly increased(p<0.05), glucose-6-phos-phatase(G-6pase)was significantly decreased(p<0.05) and The glutathione(GSH), glucokinase(GK) were increased. But not statistically significant In Lycii fructus treated group compared to the those of STZ-control group These results indicated that ethanol extract of Lycii fructus would have antidiabetic and antioxidant effects in STZ-induced diabetic rats.
Keywords
streptozotocin; antidiabetic; antioxidant effects; Lycii fructus;
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Times Cited By KSCI : 10  (Citation Analysis)
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1 Y. J. Park, M.H. Kim, and S. J. Bae, Enhancement of anticarcinogenic effect by combination of Lycii Fructus with Vitamin C. J. Korean Soc. Food Sci. Nut.31,143 (2002)   DOI
2 N. J. Kim, H. G. Youn, and N. D. Hong. Pharmacological effects of Lycium chinensis. Korean Soc. Pharmacog. 25, 264 (1994)   과학기술학회마을
3 K. S. Kim, S. H. Shin, K. H. Jeong, C. S. Cheong, K. H. Ko, J. I. Park, H. Hur, B. J. Lee, and B. K. Kim, Antidiabetic activity of constituent of Lycii Fructus, J. App. Pharmacol. 6, 378(1998)
4 O. K. Kim, The Effects of Sedum sarmentosum Bunge Extract Using Super Critical Carbon Dioxide on Lipid Metabolism, Lipid Peroxidation and Antioxidation in Carbon Tetrachloride Induced Hepatotoxicity in Rats J. Korean Oil Chem. Soc., 21, 204 (2004)   과학기술학회마을
5 M. A. Bang, Y. J. Cho and H. A. Kim, Effect of Indongcho on Glucose and Lipid Metabolism and Antioxidative Enzyme System in Streptozotocin Induced Diabetic Rat, Korean J. Dietary Culture., 17, 377 (2002)   과학기술학회마을
6 O. K. Kim, S. Y. Park, and K. H. Cho, Effect of Commelina commumis extract on blood glucose level and changes in enzymatic activity in alloxan diabetic rats, Kor. J. Pharmacogn., 22, 225 (1991)
7 S. Y. Kim, H. I. Kim, T. H. Kim, S. S. Im, and S. K. Park, SREBP-1c the Insulin Dependent Hepatic G/lucokinase Expression, J. Bio. Chem., 279, 30823 (2004)   DOI   ScienceOn
8 S. Urano, H. H. Midori, and N. Tochihi, M.Matsuo, and H.Ito, Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics. Lipids 26, 58 (1991)   DOI   ScienceOn
9 W. A. Behrens, R. Madere, Vitamin C and vitamin E satus in the spontaneously diabetic BB rat before the onset of diabetes. Metabolism 40, 72 (1991)   DOI   ScienceOn
10 C. S. Moody and H. M. Hassan. Mutagenicity of oxygen free radicals. Proc. Natl. Acsd. Sci., 79, 2855 (1982)
11 K. H. Lee, and S. H. Dhung, Antidiabetic effect and mechanism of Mori folium on streptozotocin induced diabetic mouse. Bull KH Pharma Sci 28, 87 (2000)
12 M. J. Jang and S. J. Lee. Hyperglycemic Effects of pillsmade of mulberry leaves and silworm powder in streptozotocin induced diabetic rats J. Korean Soc. Food Sci. Nutr. 33, 1611 (2004)   DOI
13 V. Vats, S. P. Yadav, and J. K. Grover, Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocininduced alterations in glycogen content and carbohydrate metabolism in rats. J. of ethnopharmacology 90, 155(2000)
14 Y. E. Chung, S. W. Kim, J. Y. Lim, E. S. Kim and J. Y. Park, Effect of Decreased Plasma Glucose Free Fatty Acids by an Antilipolytic Agent on Plasma Glucose Level and Liver Glycogen Content in Streptozotocin Induced Diabetic Rats, The Korean diabetic society, 23, 46 (1999)
15 R. S. Sohal and R. G. Allen, Oxidative stress as a causal factor indifferentiaion and aging: A unifying hypothesis. Exp. Gerontol. 25, 499 (1990)   DOI   ScienceOn
16 S. J. Lim, H. K. Han, and J. H. Ko, Effects of Edible and Medical Plants Intake on Blood Glucose, Glycogen and Protein Levels in Streptozotocin Induced Diabetic Rats, J. Korean Nutr. 36, 981 (2003)   과학기술학회마을
17 M. Latha, and L. Pari, Modulatory Effect of Scoparia dulcis in Oxidative Stress-Induced Lipid Peroxidation in Streptozotocin Diabetic Rats. J. Med. Food, 6, 379 (2003)   DOI   ScienceOn
18 V. B. C. Junqueira, K. Simiz, L. A.Videla. and S.B.Barros, Dose dependent study of the effects of acute lindamce administration on rat liver superoxide anion production antioxidant enzyme activities and lipid peroxidation. Toxicology, 41, 193 (1996)   DOI   ScienceOn
19 H. M. Hassan, Free Radical. Biol. Med., 5, 377 (1988)
20 J. Y. Kim, and B. H. Lee, Effect of the antioxidants on the diabetic complications. J. Vet Clin 18, 374 (2001)
21 M. A. Krall, A. L. P. Bradley, R. F., Christlieb, A. R., Soell, and J. S., Joslin's. Diabetes mellitus 12th ed., Lea & Febiger, Philadelphia (1985)
22 Z. Liu, E. J. Barrett, A. C. Dalkin, A. D Zwart, and J. Y. Chou, Effect of acute diabetes on the rat hepatic glucose-6- phosphatase activity and its messenger RNA level. Biochem. Biophy. Rers. Commun. 38, 680 (1994)
23 N. J. Kim, W. G. Youn, and N. D. Hong, Pharmacological effects of Torlis fructus and cuscutae Semen on the imune system in mice fed with protein deficient diet korean J. pharmacogn. 16, 264 (1994)
24 C. H. Cropo, J. M. McCord, and E. Fridovich, Preparation and Assay of Superoxide Dismutase. In Methods in Enzymology, Fleischer, D. and Packer, L.(eds.), Academic Press, 52, 382 New York (1978)
25 A. Deisseroth and A. L. Dounce, Catalase Physical and Chemical Properties, Mechanism of Catalysis and Physiological Role, Physiol. Rev. 50, 3 (1970)
26 J. D. Finkelstein, W. E. Kyle, and B. J. Harris, Methionine methabolism in mammals, regulation of homocysteine methyl transferases in rats tissue. Arch. Biochem. Biophys. 146, 84 (1971)   DOI   ScienceOn
27 R. Kakkar, J. Kalra, S. V. Mantha and K. Prasod, Lipid Peroxidation and Activity of Antioxidant Enzymes in Diabetic Rats, Molecular and Celluar Biochemistry. 151, 113 (1995)   DOI
28 Y. Y. Kim, H. J. Kang, S. K. Ko, and S. H. Chung, Sopungsungi-won(SP)prevents the onset of hyperglycemia and hyperlipidemia in Zucker diabetic fatty rats. Arch Pharm Res 25, 923 (2002)   DOI   ScienceOn
29 H. J. Lim, K. h. Cho, and R. W .Choue. The effects of functional tea(Mori Folium, Lycii Fructus, Chry santhemi Flos, Zizyphi Fructus, Sesamum Semen, Raphani Semen) supplement with medical nutrition therapy on the blood lipid levels and antioxidant status in subjects with hyperlipidemia, J. Korean Soc. Food Sci. Nutr. 34, 42 (2005)   과학기술학회마을   DOI
30 J. S. Park, Agronomic characteristics abd biological activities of new variety chungyanggugija. Ph. D. thesis, Chungnam University, daejeon, Korea (2000)
31 Y. Y. Kim, H. J. Kang, S. K. Ko and S. H. Chung, Sopungsungi-won(SP) Prevents the Onset of Hyperglycemia and Hyperlipidemia in Zucker Diabetic Fatty Rats, Arch. Pharm. Res., 25, 923 (2002)   DOI   ScienceOn
32 E. S.Tai, S. D. Lim, B. Y. Tan., S. K. Chew, and C. E. Tan Screening for diabetes mellitus: a two-step approach in individuals with impaired fasting glucose improves detection of those at risk of complications. Diabetes Med. 17, 771 (2000)   DOI   ScienceOn
33 K. M. West, M. M. S. Ahuja, and P. H. Bennett, The role of circulating glucose and triglyceride concentration and their interaction with other "risk factor" as determinants of arterial disease in nine diabetic population samples from WHO multinational study. Diabetes Care, 6, 361 (1983)   DOI   ScienceOn
34 C. K. Yoon, H. H. Kim, S. N. Chae, M. J. OH, and G. H. Lee, Hepatic oxygen free radical and alcohol metabolizing enzyme activities in rats fed diets supplemented with Lycium chinense ethanol extract, J. Korean, Soc. Food Sci. Nutr. 30 668 (2001)   과학기술학회마을
35 A. W. Ha, and H. M. Kim. The Study of lipid- peroxidation, antioxidatt enzymes, and the antioxidant vitamin in NIDDM patients with microvascular-diabetic complications. Korean J. Nutr. 21, 17 (1999)
36 G. Mithieux, H. Vidal, C. Zitoun, N. Bruni, N., Daniele, and C. Minassian, Glucose- 6-phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats: Diabetes 45 891 (1996)   DOI   ScienceOn
37 R. M. Vos and P. J. V. Bladern, Glutathione-S-transferase in Relation to Their Role in the Biotransformation of Xenobiotics. Chem. Biol. Interact., 75, 241 (1990)   DOI   ScienceOn
38 K. A. Steer, M. Sochor, and P. Mclean, Diabctes 34, 485 (1985)
39 B. A. Shibib, L. A Khan, and R. Rahman, Hypoglycaemic activity of Coccinia indica Momordica charantiain diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-l,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochemical. 292, 267 (1993)   DOI
40 T. Byers and G. Perry, Dietary Carotenes, Vitamin C and Vitamin E as Protective Antioxidants in Human Cancers. Ann. Rev. Nutr., 12, 135 (1992)
41 H. S. Kim, Y. S. park, and C. I. Kim. Changs of serum lipid profiles after eating Lycii fructus in rats fed high fat diet, Korean Nutr. Soc. 31, 263 (1998)