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http://dx.doi.org/10.12925/jkocs.2004.21.1.5

Enzymatic Synthesis of Glycosyl Acrylate and Methacrylate  

Park, Dae-Won (Department of Chemical Engineering, Yonsei University)
Kim, Hae-Sung (Department of Chemical Engineering, Myongji University)
Publication Information
Journal of the Korean Applied Science and Technology / v.21, no.1, 2004 , pp. 37-44 More about this Journal
Abstract
Glycosyl acrylate and methacrylate were synthesized by lipase-catalyzed esterification of vinyl acrylate and vinyl methacrylate with ${\beta}$-methyl glucoside in t-butanol as a reaction medium. At the optimum conditions of initial concentration of 150g/l ${\beta}$-methyl glucoside, molar ratio of 1 : 3, 5%(w/v) lipase(Novozym 435) and $50^{\circ}C$, we attained up to 100% conversion for enzymatic glycosylation of vinyl acrylate and vinyl methacrylate by supersaturated solvent process. The polymerizable glycosyl acrylates and methacrylate are expected to have biomedical application as hydrophilic monomers and hydration modifiers to be used for biocdmpatible hydrogel.
Keywords
lipase-catalyzed esterification; glycosyl acrylate/methacrylate; glycosylation;
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