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Cigarette Smoke Attenuates Histopathological and Neurobiological Changes Caused by 87V Scrapie Agent Infection in IM Mice  

Sohn Hyung-Ok (KT&G Central Research Institute)
Hyun Hak-Chul (KT&G Central Research Institute)
Shin Han-Jae (KT&G Central Research Institute)
Han Jung-Ho (KT&G Central Research Institute)
Park Chul-Hoon (KT&G Central Research Institute)
Moon Ja-Young (Department of Biochemistry and Health Sciences, College of Natural Sciences, Changwon National University)
Lim Heung-Bin (Department of Tobacco Science, College of Agriculture, Chungbuk National University)
Kim Yong-Sun (Ilsong Institute of Life Science, Hallym University)
Lee Dong-Wook (KT&G Central Research Institute)
Publication Information
Journal of the Korean Society of Tobacco Science / v.27, no.2, 2005 , pp. 212-218 More about this Journal
Abstract
Cigarette smoking has been known to have a few beneficial effects on some neuronal diseases such as Alzheimer's disease(AD), Parkinson's disease(PD) and prion disease by scrapie agent shows many similar properties with AD. In this respect, we investigated what biological effects are exerted by cigarette smoke exposure(CSE) in the brain of mouse infected by 87V scrapie. The scrapie agent was inoculated through stereotaxic microinjection of the homogenates of the scrapie agent infected brain into the intracerebral system in the 1M mice. The inoculation into mice typically exhibits neurochemical, physiological and histopathological characteristics of prion disease: loss of neurotransmitters and induction of astrocytosis and vacuolation in brain as well as reduction of spatial movement and loss of body weight. CSE led to alleviated the loss of body weight and also improved spatial movement of the infected mice. Most interestingly, CSE attenuated astrocytosis and vacuolation caused by scrapie infection in the brain. In addition, decreased levels of dopamine in striatal and hypothalamic regions as well as serotonin level in hippocampus caused by scrapie infection were also attenuated by exposure to cigarette smoke. These findings suggest that cigarette smoke, by its inhibition of astrocytosis and vacuolation followed by its restoration of levels of some neurotransmitters, may partly contribute to suppression in the progress of neurodegeneration caused by scrapie infection.
Keywords
cigarette smoke exposure; scrapie agent; neurodegeneration;
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1 Kim, Y. S., Carp, R. I., Callahan, S. M. and Wisniewski, H. M. (1987) Incubation period and survival time for mice injected stereotaxically with three scrapie strains in different brain regions. J. Gen. Virol. 68: 695-702   DOI   ScienceOn
2 Sahakian, B., Jones, G., Levey, R., Gray, J. and Warburton, D. (1989) The effect of nicotine on attention, information processing, and short term memory in patients with dementia of the Alzheimer's type. Br. J. Psychiatry 154: 797-800   DOI   ScienceOn
3 Saller, C. F. and Salama, A. I. (1984) Rapid automated analysis of biogenic arnines and their metabolities using reverse phase high performance liquid chromatography with electrochemical detection. J. Chromatogr. 309: 287-298   DOI   ScienceOn
4 Vorbrodt, A. W., Dobrogowska, D. H., Kim, Y. S., Lossinsky, A. S. and Wisniewski, H. M. (1990) Ultrastructural studies of glycoconjugates in brain micro- blood vessels and amyloid plaques of scrapie infected mice. Acta Neuropathol. 75: 227-287
5 Kim, Y. S., Carp, R. I., Callahan, S. M. and Wisniewski, H. M. (1990) Incubation period and histopathological changes in mice infected stereotaxically in different brain areas with the 87V scrapie strain. Acta Neuropathol. 80: 388-392   DOI   ScienceOn
6 Grandinetti A., Morens D. M., Reed D. and MacEachern D. (1994) Prospective study of cigarette smoking and the risk of developing idiopathic Parkinson's disease. Am J. Epidemiol. 139(12): 1129-1138
7 Ksir, C. and Benson, D. M. (1983) Enhanced behavior response to nicotine in an animal model of Alzheimer's disease. Psychopharmacol. 81: 272-273   DOI   PUBMED
8 Fonnum, F. (1975) A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24: 407-409   DOI   PUBMED
9 Sjak-Shie, N. N., Meyer, E. M. and Hunter, B. E, (1991) Cholinergic Basis for Alzheimer Therapy. pp, 379-385. Becker, R., Giacobini, G. Eds., Berlin, Berghauser
10 Ellman, G.. L., Couetney, K. D., Anders, V. Jr. and Featherstone, R. M. (1961) A new and rapid colorimetric determination of acetylcholine esterase activity. Biochem. Pharmacol. 7: 88-95   DOI   ScienceOn
11 Prusiner, S. B. (1995) The prion disease. Scientific American 272: 30-37
12 Behmand, R. A. and Harik, S. I. (1992) Nicotine enhances MPTP neurotoxicity. J. Neurochem. 58: 776-779   DOI   PUBMED
13 Bendheim, P. E., Barry, R. A., DeArmond, S. J., Stites, D. P. and Prusiner, S. B. (1984) Antibodies to a scrapie prion protein. Nature (London) 310: 418-421   DOI   ScienceOn
14 Price, D. L., Borchelt, D. R. and Sisodia, S. S. (1993) Alzheimer's disease and the prion disorders amyloid beta protein and prion protein amyloidosis. Proc. Natl. Acad Sci. USA 90: 6381-6384
15 Lee, P. N. (1994) Smoking and Alzheimer's disease: A review of the epidemiological evidence. Neuroepidemiol. 13: 131-144   DOI   PUBMED   ScienceOn
16 Carp, R. I., Callahan, S. M., Sersen, E. A. and Moretz, R. C. (1984) Preclinical changes in weight of scrapie infected mice as a function of scrapie agent-mouse strain combination. Intervirol. 21: 61-69   DOI   PUBMED
17 Wisniewski, H. M., Merz, G.. S. and Carp, R. I. (1984) Senile dementia of the Alzheimer's type : possibility of an infectious ethiology in genetically susceptible individuals. Acta Neurol. Scand. Suppl. 69: 91-99   DOI
18 Diedrich, J. F., Bendheim, P. E., Kim, Y. S., Carp, R. I. and Haase, A. T. (1991) Scrapie associated prion protein accumulates in astrocytes during scrapie infection. Proc. Natl. Acad. Sci. USA 88: 375-379
19 Maureen, E. M., Benwell, D. J., Balfour, K. and Anderson, J. M. (1988) Evidence that tobacco smoking increases the density of nicotine binding site in human brain. J. Neurochem. 50: 1243-1247   DOI   PUBMED
20 van Duijn, C. M. and Hoffman, A. (1991) Relation between nicotine intake and Alzheimer's disease. Br. Med J. 302: 1491-1494   DOI   ScienceOn
21 Bareggi, S. R., Braida, D., Gervasoni, M., Carcassola, G., Pollera, C., Verzoni, C., Sala, M. and Vergerio, C. (2003) Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters. Brain Res. 984(1-2): 237-241   DOI   PUBMED   ScienceOn