Comparison of the Sensitivity of Two Micronucleus Assays for Detection of Micronucleus Induction by Cigarette-Smoke Condensate
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Sohn Hyung-Ok
(KT&G Central Research Institute)
Lee Young-Gu (KT&G Central Research Institute) Han Jung-Ho (KT&G Central Research Institute) Hur Jae-Yeon (KT&G Central Research Institute) Lee Dong-Wook (KT&G Central Research Institute) Hyun Hak-Chul (KT&G Central Research Institute) Shin Han-Jae (KT&G Central Research Institute) |
1 | Bombick, B. R., Murli, H., Avalos, J. T., Bombick, D. W., Morgan, W. T., Putnam, K.P. and Doolittle, D. J. (1997) Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 2. In vitrotoxicity of mainstream smoke condensate. Food Chemical Toxicol. 36: 183-190 |
2 | Borenfreund, E. and Puerner, J. A. (1985)Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 24: 119-124 DOI PUBMED ScienceOn |
3 | DeMarini, D. M. (1983) Genotoxicity of tobacco smoke and tobacco smoke condensate. Mutat. Res. 114: 59-89 DOI ScienceOn |
4 | Doolittle, D. J., Lee, C. K., Ivett, J. L., Mirsalis, J. C., Riccio, E., Rudd, C. J., Burger, G. T.and Hayes A. W. (1990) Comparative studies on the genotixic activity of mainstream smoke condendsate from cigarettes which burn or only heat tobacco. Enviromentat and Motecutar Mutagenesis 15: 93-105 |
5 | Fenech, M. (1993) The cytokinesis block micro nucleus technique : A detailed description of the method and its application to geno toxicity studies in human polulations. Mutat. Res. 285: 35-44 DOI |
6 | Kirsch Volders, M., Sofuni, T., Aartema, S.A., Albertini, A., Eastmond, D., Fenech, M., Ishidata, jr, M., Lorge, E., Norppa, H.,Surralles, J., Hude, W. and Wakata, A.(2000) Report from the in vitro micronucleus assay working group. Environmental and Molecular Mutagenesis 35: 167-172 DOI ScienceOn |
7 | Roemer, E., Tewes, F. J., Meisgen, T. J., Veltel,D. J. and Carmines, E. L. (2002) Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro genotoxidty and cytotoxicity. Food Chem, Toxicol. 40: 105-111 DOI ScienceOn |
8 | Ellard, S., Mohammed, Y., Dogra, S., Wolfel, C.,Doehmer, J. and Parry, J. M. (1991) The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2and 2B1 cDNAs in micronucleus assays. Mutagenesis 6: 461-470 DOI ScienceOn |
9 | Veltel, D. and Hoheneder, A. (1996) Characterization of cigarette smoke induced micronucleic in vitro. Exp. Toxic. Pathot. 48:548-550 DOI ScienceOn |
10 | Fenech, M. (2000) The in vitro micronucleus technique. Mutat. Res. 455: 81-95 DOI |
11 | Krishna, G., Kropko, M. L. and Theiss, J. C.(1989) Use of the cytokinesis block method for the analysis of micronuclei in V79 Chinese hamster lung cells : results with mitomycin C and cyclophosphamide. Mutat. Res. 222: 63-69 DOI PUBMED ScienceOn |
12 | Kirsch Volders, M., Elhajouji, A., Cundari, E. and VanHummelen, P. (1997) The in vitro micronucleus test : a multipoint assay to detect simutaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss andnon disjunction. Mutat. Res. 392: 19-30 DOI ScienceOn |
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