Browse > Article
http://dx.doi.org/10.14579/MEMBRANE_JOURNAL.2019.29.4.231

Fabrication and Characterizations of Interpenetrating Polymer Network Hydrogel Membrane Containing Hydrogel Beads  

Kim, Do-Hyeong (Department of Green Chemical Engineering, Sangmyung University)
Kang, Moon-Sung (Department of Green Chemical Engineering, Sangmyung University)
Publication Information
Membrane Journal / v.29, no.4, 2019 , pp. 231-236 More about this Journal
Abstract
In this study, alginate-based hydrogel membranes composed of hydrogel beads and highly tough hydrogel matrix including moisturizing oil and natural emulsifier were prepared and their elution characteristics were evaluated. As a result, it was confirmed that the elution rate of the moisturizing oil component can be controlled within a desired range by controlling the composition of the hydrogel bead and the tough hydrogel matrix. In particular, it has been confirmed that by combining tough hydrogel having a structure of interpenetrating polymer network (IPN) and hydrogel beads, the physical stability of the membranes can be improved and the elution rate of the moisturizing oil can also be controlled more finely.
Keywords
hydrogel beads; tough hydrogel matrix; moisturizing oil; emulsifier; interpenetrating polymer network;
Citations & Related Records
연도 인용수 순위
  • Reference
1 S. Ramos, V. Homem, A. Alves, and L. Santos, "Advances in analytical methods and occurrence of organic UV-filters in the environment - A review", Sci. Total Environ., 526, 278 (2015).   DOI
2 J. Shin, J. H. Cho, and S.-W. Cho, "Functional hydrogel for the application of drug delivery and tissue engineering", KIC News, 18, 2 (2015).
3 S. C. Song, J. K. Cho, and C. J. Chun, "Drug delivery technology using hydrogel", NICE, 28, 171 (2010).
4 T. R. Hoare and D. S. Kohane, "Hydrogels in drug delivery: Progress and challenges", Polymer, 49, 1993 (2008).   DOI
5 X. Hou, L. Mu, F. Chen, and X. Hu, "Emerging investigator series: Design of hydrogel nanocomposites for the detection and removal of pollutants: From nanosheets, network structures and biocompatibility to machine-learning-assisted design", Environ. Sci.: Nano, 5, 2216 (2018).   DOI
6 Y. l. Lee, M. Gulfam, and B. G. Chung, "Microtechnologies and functional hydrogels for tissue engineering applications", Polymer Science and Technology, 22, 454 (2011).
7 J. Fu and M. Panhuis, "Hydrogel properties and applications", J. Mater. Chem. B, 7, 1523 (2019).   DOI
8 A. Ishikawa, M. Fujii, K. Morimoto, T. Yamada, N. Koizumi, M. Kondoh, and Y. Watanabe, "Oil-in-water emulsion lotion providing controlled release using 2-methacryloyloxyethyl phosphorylcholine n-butyl methacrylate copolymer as emulsifier", Results Pharma Sci., 2, 16 (2012).   DOI
9 S. G. Lee, S. R. Kim, H. I. Cho, M. H. Kang, D. W. Yeom, S. H. Lee, S. k. Lee, and Y. W. Choi, "Hydrogel-based ultra-moisturizing cream formulation for skin hydration and enhanced dermal drug delivery", Biol. Pharm. Bull., 37, 1674 (2014).   DOI
10 B. Semmling, S. Nagel, K. Sternberg, W. Weitschies, and A. Seidlitz, "Development of hydrophobized alginate hydrogels for the vessel-simulating flow-through cell and their usage for biorelevant drug-eluting stent testing", AAPS Pharm. Sci. Tech., 14, 1209 (2012).
11 J.-Y. Sun, X. Zhao, W. R. K. Illeperuma, O. Chaudhuri, K. H. Oh, D. J. Mooney, J. J. Vlassak, and Z. Suo, "Highly stretchable and tough hydrogels", Nature, 489, 133 (2012).   DOI
12 T.-H. Kim and Y.-C. Nho, "Synthesis of PVA/PVP hydrogel by irradiation crosslinking", Polymer (Korea), 25, 270 (2001).
13 Enas M. Ahmed, "Hydrogel: Preparation, characterization", J. Adv. Res., 6, 105 (2015).   DOI
14 N. Chirani, L'H. Yahia, L. Gritsch, F. L. Motta, S. Chirani, and S. Fare, "History and applications of hydrogels", J. Biomed. Sci., 4, 1 (2015).   DOI
15 D. Mark, S. Haeberle, R. Zengerle, J. Ducree, and G. T. Vladisavljevic, "Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle", J. Colloid Interface Sci., 336, 634 (2009).   DOI
16 M. Bahram, N. Mohseni, and M. Moghtader, "An introduction to hydrogels and some recent applications", Emerging Concepts in Analysis and Applications of Hydrogels, 24, (2016).
17 C. L. Heaysman, G. J. Phillips, A. W. Lloyd, and A. L. Lewis, "Synthesis and characterisation of cationic quaternary ammonium modified polyvinyl alcohol hydrogel beads as a drug delivery embolisation system", J. Mater. Sci. Mater. Med., 27(53), 1 (2016).
18 C. B. Jeong, J. Y. Han, J. C. Cho, K. D. Suh, and G. W. Nam, "Analysis of electrical property changes of skin by oil-in-water emulsion components", Int. J. Cosmet. Sci., 35, 402 (2013).   DOI
19 B. Zeeb, A. H. Saberi, J. Weissa, and D. J. McClements, "Retention and release of oil-in-water emulsions from filled hydrogel beads composed of calcium alginate: Impact of emulsifier type and pH", Soft Matter., 11, 2228 (2015).   DOI
20 W.-P. Voo, C.-W. Ooi, A. Islam, B.-T. Tey, and E.-S. Chan, "Calcium alginate hydrogel beads with high stiffness and extended dissolution behaviour", Eur. Polym. J., 75, 343 (2016).   DOI
21 H. Tokuyama and N. Yazaki, "Preparation of poly(N-isopropylacrylamide) hydrogel beads by circulation polymerization", React. Funct. Polym., 70, 967 (2010).   DOI
22 F. Topuz and O. Okay, "Macroporous hydrogel beads of high toughness and superfast responsivity", React. Funct. Polym., 69, 273 (2009).   DOI
23 M. H. Lee, S. J. Kim, and S. N. Park, "Development of porous cellulose-hydrogel system for enhanced transdermal delivery of quercetin and rutin", Polymer(Korea), 37, 347 (2013).