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Preparation of Polyphosphazene Diagnostic Membranes for Blood Glucose Measurements  

Kwon, Suk-Ky (Department of Biological and Chemical Engineering, Hongik University)
Publication Information
Membrane Journal / v.21, no.4, 2011 , pp. 329-335 More about this Journal
Abstract
A new type of diagnostic membranes based on methoxyethoxy and trifluoroethoxy co-substituted polyphosphazene has been prepared to measure blood glucose level of diabetics. Final absorbances at 680 nm through activated polyphosphazene membranes were measured at various concentration of glucose in plasma or blood. The end-point results of varing absorbance values as time (K/S) was found to have a linear relationship toward the blood glucose concentration. The effects of substitution rates with hydrophilic groups and hydrophobic groups on the measurements of glucose concentration were studied. Dose-response slope (DRS) values between glucose concentration and K/S values increased as the hydrophilic substitution rates increased. However, in more than 30% of the substitution rates, it was difficult to measure exact concentration level of glucose because DRS increased rapidly.
Keywords
polyphosphazene; membranes; diabetics; glucose;
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Times Cited By KSCI : 4  (Citation Analysis)
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