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Synthesis of Lactide/Hyaluronic Acid Polymer Membrane for the Application of Drug Delivery System  

Kim, Min-Su (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Kwon, Ji-Young (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Cheong, Seong-Ihl (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Publication Information
Membrane Journal / v.15, no.4, 2005 , pp. 281-288 More about this Journal
Abstract
The hyaluronic acid (HA) with excellent biocompatibility can be combined with lactide, the ester dimer of polylactide, with good biodegradability to produce biocompatible materials applicable to drug delivery system. By freeze drying method, HA and lactide were crosslinked with crosslinking agent, 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide. Degree of lactide and EDC reaction was determined by the analysis of nuclear magnetic resonance (NMR) spectroscopy. The degree of lactide and EDC reaction increased and swelling ratio decreased as the mole ratio of lactide to HA or crosslinking agent concentration increased or reaction temperature decreased. The drug release experiment result from membranes having different degree of lactide reaction showed that drug release rate reduced in proportion to the degree of lactide reaction. The drug release experiment result from drugs having different hyrodphobicity showed that the more hydrophobic drug was released more slowly.
Keywords
hyaluronic acid; lactide; crosslinking; swelling; drug release;
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