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Blood Compatibility of Hollow Fiber Membranes Treated by Plasma Polymerization  

Lee, Sam-Cheol (Department of Advanced Materials Engineering, Hanlyo University)
Kwon, O-Sung (School of Advanced Materials Engineering, Chonbuk National University)
Publication Information
Membrane Journal / v.15, no.3, 2005 , pp. 233-240 More about this Journal
Abstract
Surface modification of polypropylene hollow fiber membranes was performed in order to develop blood-compatibility biomaterials for use in the blood contacting surfaces and oxygenation membranes of a lung assist device (LAD), important medical device even more useful. Blood compatibility of materials was determined by using anticoagulation blood and evaluating formation of blood clots on their surfaces as well as activation of plasma coagulation cascade, platelet adhesion, and aggregation. It was verified that the number of platelets on the silicone coated fibers was significantly lower than that on untreated fiber membrane, indicating improved blood compatibility. It was also found that the polypropylene hollow fiber membranes using plasma treatment exhibited suppression of complement activation in blood compatibility test.
Keywords
blood compatibility; polypropylene hollow fiber membranes; plasma polymerization;
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