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Characterization of Hyaluronic Acid Membrane Containing Lactic Acid  

Cheong Seong Ihl (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Kwon Ji Young (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Publication Information
Membrane Journal / v.15, no.1, 2005 , pp. 8-14 More about this Journal
Abstract
The hyaluronic acid (HA) with excellent biocompatibility can be combined with the monomer polylactide with good biodegradability to produce biocompatible materials which can control the period of degradation in a human body. By freeze drying method, HA and the lactic acid, monomer of polylactide, or lactide, the ester dimer of polylactide, were crosslinked with crosslinking agent, l-ethyl-3-(3-dimethyl aminopropyl) carbodiimide. The analysis of infrared spectroscopy showed that the ester linkage was formed and the analysis of nuclear magnetic resonance (NMR) spectroscopy showed that the ester linkage was due to the reaction of lactic acid and HA. The conversion (6∼32%) and degree of crosslinking (4∼19%) increased but the selectivity was almost constant at 62% as the mole ratio of LA to HA increased from 1 to 10 in the crosslinking reaction. The brittleness became more pronounced and the rate of degradation became faster with more addition of lactic acid resulting from the higher ratio of LA to HA, and the swelling ratio was in the range of 500 to 2000%.
Keywords
hyaluronic acid; lactic acid; crosslinking; swelling; degradation;
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