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Preparation of Alginate Microspheres Using Membrane Emulsification Method  

Youm Kyung Ho (충북대학교 공과대학 화학공학부)
Choi Yong Han (충북대학교 공과대학 화학공학부)
Dianne E. Wiley (호주 뉴사우스웨일즈대학교 UNESCO 막과학기술연구소)
Publication Information
Membrane Journal / v.14, no.3, 2004 , pp. 218-229 More about this Journal
Abstract
We prepared monodispersed calcium alginate microspheres by controlling various conditions of emulsification procedure using a lab-scale batch type membrane emulsification system equipped with SPG (Shirasu porous glass) tubular membranes. We determined the effects of process parameters of membrane emulsification (ratio of dispersed phase to continuous phase, alginate concentration, emulsifier concentration, type and concentration of stabilizer, transmembrane pressure, concentration of crosslinking agent, stirring speed and membrane pore size) on the mean size and size distribution of alginate microspheres. The increase of the ratio of dispersed phase to continuous phase, transmembrane pressure and alginate concentration led to the increase in the mean size of alginate microspheres. On the contrary, the increase in emulsifier concentration, stirring speed of the continuous phase and concentration of the crosslinking agent caused the reduction of the mean size of microspheres. Through controlling these parameters, monodisperse alginate microspheres with about $6{\mu}{\textrm{m}}$ of the mean size and 1.1 of the size distribution value were finally prepared in case of the using SPC membrane with the pore size of $2.9{\mu}{\textrm{m}}$.
Keywords
Membrane emulsification; SPG membrane; Microspheres; Calcium alginate;
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