Browse > Article
http://dx.doi.org/10.5139/JKSAS.2008.36.6.587

Development of shock wave induced microparticle acceleration system based on laser ablation and its application on drug delivery  

Choi, Ji-Hee (서울대학교 기계항공공학부 대학원)
Gojani, Ardian B. (서울대학교 기계항공공학부 대학원)
Lee, Hyun-Hee (서울대학교 기계항공공학부 대학원)
Yoh, Jai-Ick (서울대학교 기계항공공학부)
Publication Information
Journal of the Korean Society for Aeronautical & Space Sciences / v.36, no.6, 2008 , pp. 587-593 More about this Journal
Abstract
Transdermal and topical drug delivery with minimal tissue damage has been an area of vigorous research for years. Our research team has initiated the development of an effective method for delivering drug particles across the skin (transdermal) for systemic circulation, and to localized (topical) areas. The device consists of a laser ablation based micro-particle acceleration system that can be integrated with endoscopic surgical techniques. We have successfully delivered 3μm size cobalt particles into gelatin models that represent soft tissue with remarkable penetration depth.
Keywords
Laser ablation; Shock wave; Bio-Ballistic gu; Drug delivery; Micro-particle acceleration;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Sedov, L. I., "Similarity and Dimensional Methods in Mechanics", CRC, Florida, 1993
2 Kendall, M., "The delivery of particulate vaccines and drugs to human skin with a practical, hand-held shock tube-based system", Shock Waves, Vol. 12, No. 23, 2002
3 Kendall, M., Mitchell, T., and Wrighton-Smith, P., "Intradermal ballistic delivery of micro-particles into excised human skin for pharmaceutical applications", J. Biochem., Vol. 37, No. 1733, 2004
4 Choi, J., Lee, H., and Yoh, J., "Microparticle acceleration device development for efficient drug delivery", AJCPP, 2008
5 Gojani, A., Menezes, V., Yoh, J., and Takayama, K., "Mechanism of micro particle acceleration by laser ablation", AJCPP, 2008
6 Russo, R. E., "Laser ablation", Appl. spectrosc., Vol. 49, No. 9, 1995
7 Yoh, J., Lee, H., Choi, J., Lee, K., and Kim, K., "Ablation induced explosion of metal using high power Nd:YAG laser", J. Appl. Phys., Vol. 103, No. 5, 2008
8 Yoh, J., Kim, K., Lee, K., Lee, H., and Park, K., "Innovative Modeling of Shock Wave Assisted Drug Particle Acceleration", World Congress on Medical Physics and Biomedical Engineering, 2006
9 Zheng, Z., et al., "The characteristics of confined ablation in laser propulsion", Chin. Phys. Soc., Vol. 15, No. 3, 2006
10 Fabbro, R. Fournier, J., Ballard, P., and Devaux, D., "Physical study of laser-produced plasma in confined geometry", J. Appl. Phys., Vol. 68, No. 2, 1990
11 Callies, G., Berger, P., and Helmut, H., "Time-resolved observation of gas-dynamic discontinuities arising during excimer laser ablation and their interpretation", J. Phys. D: Appl. Phys, Vol 28, 1995, pp. 794-806   DOI   ScienceOn
12 Menezes, V., Takayama, K., Ohki, T., and Gopalan, J., "Laser-ablation-assisted microparticle acceleration for drug delivery", Appl. Phys. Lett., Vol. 87, No. 163504, 2005
13 Gojani, A., Yoh, J., and Yoo, J., "Crater depths for aluminum and copper at high irradiances by nanosecond visible laser pulses", Appl. Surf. Sci., in review, (2008)
14 Klein, T. M., Wolf, E. D., Wu, R., and Sanford, J. C., "High-velocity microprojectiles for delivering nucleic acids into living cells", Nature (London), Vol. 327, No. 70, 1987
15 Quinlan, N. J., Kendall, M., Bellhouse, B. J., and Ainsworth, R. W., "Investigations of gas and particle dynamics in first generation needle-free drug delivery devices", Shock Waves, Vol. 10, No. 395, 2001