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http://dx.doi.org/10.15433/ksmb.2021.13.2.094

Anti-glycation effect and renal protective activity of Colpomenia sinuosa extracts against advanced glycation end-products (AGEs)  

Kim, Mingyeong (Department of Food Biotechnology, University of Science and Technology)
Cho, Chi Heung (Division of Food Functionality Research, Korea Food Research Institute)
Kim, Sera (Division of Food Functionality Research, Korea Food Research Institute)
Choi, In-Wook (Division of Food Functionality Research, Korea Food Research Institute)
Lee, Sang-Hoon (Division of Food Functionality Research, Korea Food Research Institute)
Publication Information
Journal of Marine Bioscience and Biotechnology / v.13, no.2, 2021 , pp. 94-103 More about this Journal
Abstract
Here, we evaluated the anti-glycation effects and renal protective properties of 70% (v/v) ethanolic extract of Colpomenia sinuosa (CSE) against AGEs -induced oxidative stress and apoptosis at different concentrations (1, 5, and 20 ㎍/mL). At 20 ㎍/mL, CSE showed that anti-glycation activities via the inhibition of AGE formation (51.1%), inhibition of AGEs-protein cross-linking (61.7%), and breaking of AGEs-protein cross-links (33.3%), were significantly (###p < 0.001 vs. non-treated group) lower than the nontreated group. Methylglyoxal (MGO) significantly (***p < 0.001) reduced cell viability (24.4%) and increased reactive oxygen species (ROS) level (642.3%), MGO accumulation (119.4 ㎍/mL), and apoptosis (55.0%) in mesangial cells compared to the nontreated group. Pretreatment with CSE significantly (###p < 0.001) increased cell viability (57.8%) and decreased intracellular ROS (96.5%), MGO accumulation (80.0 ㎍/mL), and apoptosis (22.6%) at 20 ㎍/mL. Additionally, we confirmed intracellular AGEs reduction by CSE pretreatment. Consequently, our results suggest that CSE is a good source of natural therapeutics for managing diabetic complications by the antiglycation effect and renal protective activity against MGO-induced oxidative stress.
Keywords
Colpomenia sinuosa; marine algae; advanced glycation end-products; renal protective effect; diabetic complications;
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