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http://dx.doi.org/10.15433/ksmb.2017.9.2.049

Streptomyces sp. DG-2 with Anti-MRSA (Methicillin Resistant Staphylococcus aureus) Activity  

Jeong, Seong-Yun (Department of Biomedical Science, Daegu Catholic University)
Publication Information
Journal of Marine Bioscience and Biotechnology / v.9, no.2, 2017 , pp. 49-57 More about this Journal
Abstract
We isolated marine bacterium, isolate DG-2 which produces the antibiotics against MRSA (methicillin-resistant Staphylococcus aureus). This isolate DG-2 was examined by its morphological, biochemical properties, and 16S rRNA sequencing analysis. And then, isolate DG-2 was identified to the genus Streptomyces. Therefore, this isolate was designated as Streptomyces sp. DG-2. Streptomyces sp. DG-2 grew relatively well at $25^{\circ}C$, pH 7.0, and NaCl 1.0%. For the pre-purification of the bioactive compounds, DG-2 was fermented in 30 L PPES-II medium, and the culture filtrates of DG-2 was extracted by ethyl acetate. The ethyl acetate extract of DG-2 showed the significant anti-MRSA and antibacterial activities.
Keywords
Antibacterial; Anti-MRSA activity; Crude extract; Methicillin-resistant Staphylococcus aureus;
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