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http://dx.doi.org/10.17135/jdhs.2018.18.4.210

Association of Periodontitis with Serum Vitamin D Level among Korean Adults  

Kim, Jaemin (Department of Family Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine)
Hwang, Hee-jin (Department of Family Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine)
Publication Information
Journal of dental hygiene science / v.18, no.4, 2018 , pp. 210-217 More about this Journal
Abstract
Periodontal disease is a chronic inflammatory disease that affects quality of life and nutrition. Several studies have demonstrated a link between periodontal disease and low bone density, and vitamin D is expected to have a beneficial effect on periodontal disease as well as on bone mineral density and anti-inflammatory effects. The purpose of this study was to identify the association between periodontal disease and vitamin D because the results are different in some studies and there is a lack of research in Korea. In this study, we conducted a multiple linear regression analysis of 8,783 subjects among 23,626 subjects who were older than 20 years of age, who had serum vitamin D levels and periodontal disease, who had three years of the National Health and Nutrition Survey that was conducted in Korea from 2012 to 2014. We examined the relationship between serum vitamin D levels and periodontal disease. Tooth loss and vitamin D levels were negatively correlated (${\beta}=-0.028$, p=0.008). In addition, the prevalence of periodontal disease was found to be higher in men younger than 50 years of age with lower vitamin D levels (Q1: 1.769 [1.125~2.782], Q2: 1.182 [0.743~1.881], Q3: 0.676 [0.400~1.881]; p=0.001). Low vitamin D levels and periodontal disease are common diseases in primary care. Vitamin D supplementation is expected to have favorable effect on periodontal disease and falls, osteoporosis, osteoarthritis, and cancer. Therefore, patients with periodontal disease may benefit from periodic vitamin D management to improve quality of life as well as to manage periodontal disease. In addition, as shown in this study, not only elderly individuals, but also men younger than 50 years of age are related to periodontal disease, so there should be interest in controlling the levels of vitamin D in adults.
Keywords
Adult; Periodontal diseases; Vitamin D;
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1 Hung HC, Willett W, Merchant A, Rosner BA, Ascherio A, Joshipura KJ: Oral health and peripheral arterial disease. Circulation 107: 1152-1157, 2003.   DOI
2 Joshipura KJ, Hung HC, Rimm EB, Willett WC, Ascherio A: Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke 34: 47-52, 2003.   DOI
3 Banik A, Schwarzer R, Knoll N, Czekierda K, Luszczynska A: Self-efficacy and quality of life among people with cardiovascular diseases: a meta-analysis. Rehabil Psychol 63: 295-312, 2018. https://doi.org/10.1037/rep0000199   DOI
4 Joshipura KJ, Douglass CW, Willett WC: Possible explanations for the tooth loss and cardiovascular disease relationship. Ann Periodontol 3: 175-183, 1998. https://doi.org/10.1902/annals.1998.3.1.175   DOI
5 Walls AW, Steele JG, Sheiham A, Marcenes W, Moynihan PJ: Oral health and nutrition in older people. J Public Health Dent 60: 304-307, 2000. https://doi.org/10.1111/j.1752-7325.2000.tb03339.x   DOI
6 Marshall TA, Warren JJ, Hand JS, Xie XJ, Stumbo PJ: Oral health, nutrient intake and dietary quality in the very old. J Am Dent Assoc 133: 1369-1379, 2002. https://doi.org/10.14219/jada.archive.2002.0052   DOI
7 Norlen P, Steen B, Birkhed D, Bjorn AL: On the relations between dietary habits, nutrients, and oral health in women at the age of retirement. Acta Odontol Scand 51: 277-284, 1993. https://doi.org/10.3109/00016359309040578   DOI
8 Ritchie CS, Joshipura K, Hung HC, Douglass CW: Nutrition as a mediator in the relation between oral and systemic disease: associations between specific measures of adult oral health and nutrition outcomes. Crit Rev Oral Biol Med 13: 291-300, 2002. https://doi.org/10.1177/154411130201300306   DOI
9 Chapuy MC, Arlot ME, Duboeuf F: Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327:1637-1642, 1992. https://doi.org/10.1056/nejm199212033272305   DOI
10 Dawson-Hughes B, Harris SS, Krall EA, Dallal GE: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337: 670-676, 1997. https://doi.org/10.1056/nejm199709043371003   DOI
11 D'Ambrosio D, Cippitelli M, Cocciolo MG: Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest 101: 252-262, 1998. https://doi.org/10.1172/jci1050   DOI
12 Azizieh F, Alyahya KO, Raghupathy R: Association between levels of vitamin D and inflammatory markers in healthy women. J Inflamm Res 9: 51-57, 2016. https://doi.org/10.2147/jir.s103298
13 Gunville CF, Mourani PM, Ginde AA: The role of vitamin D in prevention and treatment of infection. Inflamm Allergy Drug Targets 12: 239-245, 2013.   DOI
14 Hirsch D, Archer FE, Joshi-Kale M, Vetrano AM, Weinberger B: Decreased anti-inflammatory responses to vitamin D in neonatal neutrophils. Mediators Inflamm 2011: 598345, 2011. https://doi.org/10.1155/2011/598345.
15 Walters MR: Newly identified actions of the vitamin D endocrine system. Endocr Rev 13: 719-764, 1992. https://doi.org/10.1210/edrv-13-4-719
16 Vojinovic J: Vitamin D receptor agonists' anti-inflammatory properties. Ann N Y Acad Sci 1317: 47-56, 2014. https://doi.org/10.1111/nyas.12429   DOI
17 Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ: Calcium and the risk for periodontal disease. J Periodontol 71: 1057-1066, 2000. https://doi.org/10.1902/jop.2000.71.7.1057   DOI
18 Pinto JPNS, Goergen J, Muniz FWMG, Haas AN: Vitamin D levels and risk for periodontal disease: a systematic review. J Periodontal Res 53: 298-305, 2018. https://doi.org/10.1111/jre.12531   DOI
19 Negrato CA, Tarzia O, Jovanovic L, Chinellato LE: Periodontal disease and diabetes mellitus. J Appl Oral Sci 21: 1-12, 2013.
20 Johannsen A, Susin C, Gustafsson A: Smoking and inflammation: evidence for a synergistic role in chronic disease. Periodontol 2000 64: 111-126, 2014. https://doi.org/10.1111/j.1600-0757.2012.00456.x
21 Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR: Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 30: 771-777, 2002. https://doi.org/10.1016/S8756-3282(02)00692-0   DOI
22 Tanaka K, Miyake Y, Okubo H: Calcium intake is associated with decreased prevalence of periodontal disease in young Japanese women. Nutr J 13: 109, 2014. https://doi.org/10.1186/1475-2891-13-109   DOI
23 Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff- Ferrari HA: Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr 80: 108-113, 2004.
24 Chapuy MC, Preziosi P, Maamer M: Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7: 439-443, 1997. https://doi.org/10.1007/s001980050030   DOI
25 Dawson-Hughes B: Impact of vitamin D and calcium on bone and mineral metabolism in older adults. In: Holick MF, ed. Biologic effects of light 2001: Proceedings of a Symposium Boston, Massachusetts June 16-18, 2001. Springer US, Boston, MA, pp.175-183, 2002.
26 Scharla SH: Prevalence of subclinical vitamin D deficiency in different European countries. Osteoporos Int 8 Suppl 2: S7-S12, 1998. https://doi.org/10.1007/PL00022726
27 Abreu OJ, Tatakis DN, Elias-Boneta AR: Low vitamin D status strongly associated with periodontitis in Puerto Rican adults. BMC Oral Health 16: 89, 2016. https://doi.org/10.1186/s12903-016-0288-7   DOI
28 Bischoff HA, Stahelin HB, Dick W: Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18: 343-351, 2003. https://doi.org/10.1359/jbmr.2003.18.2.343   DOI
29 McAlindon TE, Felson DT, Zhang Y: Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med 125: 353-359, 1996.   DOI
30 Martínez ME, Willett WC: Calcium, vitamin D, and colorectal cancer: a review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev 7: 163-168, 1998.
31 Shin MH, Holmes MD, Hankinson SE, Wu K, Colditz GA, Willett WC: Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst 94: 1301-1311, 2002. https://doi.org/10.1093/jnci/94.17.1301   DOI
32 Spiro A, Buttriss JL: Vitamin D: an overview of vitamin D status and intake in Europe. Nutr Bull 39: 322-350, 2014. https://doi.org/10.1111/nbu.12108   DOI
33 Warren JJ, Watkins CA, Cowen HJ, Hand JS, Levy SM, Kuthy RA: Tooth loss in the very old: 13-15-year incidence among elderly Iowans. Community Dent Oral Epidemiol 30: 29-37, 2002. https://doi.org/10.1034/j.1600-0528.2002.300105.x   DOI
34 Ong G: Periodontal reasons for tooth loss in an Asian population. J Clin Periodontol 23: 307-309, 1996. https://doi.org/10.1111/j.1600-051X.1996.tb00550.x   DOI
35 Phipps KR, Stevens VJ: Relative contribution of caries and periodontal disease in adult tooth loss for an HMO dental population. J Public Health Dent 55: 250-252, 1995. https://doi.org/10.1111/j.1752-7325.1995.tb02377.x   DOI
36 Stabholz A, Babayof I, Mersel A, Mann J: The reasons for tooth loss in geriatric patients attending two surgical clinics in Jerusalem, Israel. Gerodontology 14: 83-88, 1997. https://doi.org/10.1111/j.1741-2358.1997.tb00182.x
37 Anand N, Chandrasekaran SC, Rajput NS: Vitamin D and periodontal health: current concepts. J Indian Soc Periodontol 17: 302-308, 2013. https://doi.org/10.4103/0972-124x.115645   DOI
38 Harnack LJ, Steffen L, Zhou X, Luepker RV: Trends in vitamin D intake from food sources among adults in the Minneapolis-St Paul, MN, metropolitan area, 1980-1982 through 2007-2009. J Am Diet Assoc 111: 1329-1334, 2011. https://doi.org/10.1016/j.jada.2011.06.009   DOI
39 Okubo H, Sasaki S, Murakami K: Designing optimal food intake patterns to achieve nutritional goals for Japanese adults through the use of linear programming optimization models. Nutr J 14: 57, 2015. https://doi.org/10.1186/s12937-015-0047-7   DOI
40 Kim MY, Kim MJ, Ly SY: Vitamin D intake, serum 25OHD, and bone mineral density of Korean adults: based on the Korea National Health and Nutrition Examination Survey (KNHANES, 2011). J Nutr Health 49: 437-446, 2016. https://doi.org/10.4163/jnh.2016.49.6.437
41 Aksnes L, Aarskog D: Plasma concentrations of vitamin D metabolites in puberty: effect of sexual maturation and implications for growth. J Clin Endocrinol Metab 55: 94-101, 1982.   DOI
42 Specker BL, Ho ML, Oestreich A: Prospective study of vitamin D supplementation and rickets in China. J Pediatr 120: 733-739, 1992. https://doi.org/10.1016/S0022-3476(05)80236-7   DOI
43 Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ: The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol 71: 1492-1498, 2000. https://doi.org/10.1902/jop.2000.71.9.1492   DOI
44 Page RC, Kornman KS: The pathogenesis of human periodontitis: an introduction. Periodontol 2000 14: 9-11, 1997. https://doi.org/10.1111/j.1600-0757.1997.tb00189.x
45 Van den Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcq L, Bouillon R: Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab 88: 4623-4632, 2003. https://doi.org/10.1210/jc.2003-030358   DOI
46 Bando K, Nitta H, Matsubara M, Ishikawa I: Bone mineral density in periodontally healthy and edentulous postmenopausal women. Ann Periodontol 3: 322-326, 1998. https://doi.org/10.1902/annals.1998.3.1.322   DOI
47 Krall EA, Dawson-Hughes B, Papas A, Garcia RI: Tooth loss and skeletal bone density in healthy postmenopausal women. Osteoporos Int 4: 104-109, 1994. https://doi.org/10.1034/j.1600-0528.2002.300105.x   DOI
48 Krall EA, Garcia RI, Dawson-Hughes B: Increased risk of tooth loss is related to bone loss at the whole body, hip, and spine. Calcif Tissue Int 59: 433-437, 1996.   DOI
49 Payne JB, Reinhardt RA, Nummikoski PV, Dunning DG, Patil KD: The association of cigarette smoking with alveolar bone loss in postmenopausal females. J Clin Periodontol 27: 658-664, 2000. https://doi.org/10.1034/j.1600-051x.2000.027009658.x   DOI
50 Payne JB, Reinhardt RA, Nummikoski PV, Patil KD: Longitudinal alveolar bone loss in postmenopausal osteoporotic/ osteopenic women. Osteoporos Int 10: 34-40, 1999. https://doi.org/10.1007/s001980050191   DOI
51 Wactawski-Wende J, Grossi SG, Trevisan M: The role of osteopenia in oral bone loss and periodontal disease. J Periodontol 67 Suppl 10S: 1076-1084, 1996. https://doi.org/10.1902/jop.1996.67.10s.1076   DOI
52 DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM: Dental disease and risk of coronary heart disease and mortality. BMJ 306: 688-691, 1993.   DOI
53 Alshouibi EN, Kaye EK, Cabral HJ, Leone CW, Garcia RI: Vitamin D and periodontal health in older men. J Dent Res 92: 689-693, 2013. https://doi.org/10.1177/0022034513495239   DOI
54 Jacques PF, Sulsky SI, Sadowski JA, Phillips JC, Rush D, Willett WC: Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient status. Am J Clin Nutr 57: 182-189, 1993. https://doi.org/10.1093/ajcn/57.2.182   DOI
55 Sowers MR, Wallace RB, Hollis BW, Lemke JH: Parameters related to 25-OH-D levels in a population-based study of women. Am J Clin Nutr 43: 621-628, 1986. https://doi.org/10.1093/ajcn/43.4.621   DOI
56 Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B: Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 111: 452-456, 2001. https://doi.org/10.1016/S0002-9343(01)00899-3   DOI