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http://dx.doi.org/10.17135/jdhs.2015.15.2.238

Antibacterial Effect and Cytotoxicity of Desensitizer Containing Antimicrobial  

Lee, Hyun-Ok (Department of Dental Hygiene, Wonkwang Health Science University)
Park, Ji-Young (Department of Dental Hygiene, Wonkwang Health Science University)
Publication Information
Journal of dental hygiene science / v.15, no.2, 2015 , pp. 238-245 More about this Journal
Abstract
Dentinal hypersensitivity is a type of dental pain that occurs when various stimuli are applied to exposed dentin lesions. If the symptoms of dentinal hypersensitivity continue, the dentin is exposed and the hypersensitivity may become a periodontal disease or root caries due to bacterial infection. Therefore, the clinical goal of the present study is to reduce the pain of the patient suffering from dentinal hypersensitivity by developing antimicrobial hypersensitivity treatments and to improve oral hygiene. We prepared chlorhexidine, tetracycline, cetylpyridinium chloride, gallic acid loaded desensitizer by adding 0.1%, 0.5%, 1.0%, and 2.0% chlorhexidine, tetracycline, cetylpyridinium chloride, gallic acid to desensitizer (Micro Prime; Denville and Hurri Seal; Beutlich), and antibacterial effect, and cytotoxicity. The antibacterial test by using Staphylococcus aureus (SA. ATCC 6538, FDA 209) showed that the antibacterial effect of all experimental groups was significantly higher than that of control group (p<0.05). Cytotoxicity test by using agar diffusion assay indicated that Micro Prime showed mild toxicity, Hurri Seal showed severe toxicity and this cytotoxicity is supposed to be caused by one of desensitizer components showing weak antibacterial effect.
Keywords
Antibacterial effect; Cytotoxicity; Micro Prime; Hurri Seal;
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