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Property and Bio-adhesiveness in Hydrogel Material with Content of Ketorolac and Gardeniae Fructus Hydrolysis Products  

Kim, Mi-Jeong (Department of Dental Hygiene, Vision University of Jeonju)
Publication Information
Journal of dental hygiene science / v.10, no.2, 2010 , pp. 79-83 More about this Journal
Abstract
This study manufactured hydrogel, which was contained NSAIDs(non-steroidal anti-inflammatory drugs) Ketorolac tromethamine and hydrolyzed products of gardeniae fructus extract, and experimented viscosity, surface tension, tensile strength and bio-adhesiveness by using hairless mouse. Thus, it was performed in expectation for being probably able to develop as effective auxiliary agent of periodontal disease after non-surgical or surgical periodontal treatment. As a result, the following conclusions were obtained. 1. Out of KGE and KGH gel materials, the content of ketorolac tromethamine was 1.02~0.97%. The content of geniposide was 0.34% in KGE gel A and C. However, it got lower to 0.11% in KGH gel B and D. The content of genipin wasn't shown in KGE gel A and C, but was shown with 0.13% in KGH gel B and D. 2. As for viscosity according to temperature in gel material, the gel, which used independently Carbopol 940 as gel inoculant, maintained the higher viscosity than the gel, which added Poloxamer 407. The surface tension in each material showed 34.77~40.58 dyne/cm at 37. As for tensile strength in material, KGH gel B was shown the higher tensile strength in about 3.5 times compared to the control group. 3. As for bio-adhesiveness, the back-skin upper part(epidermis) and abdomen skin were shown to be 50.62 N in KGH gel B, thereby having indicated higher value in about 5 times compared to control group. The back-skin lower part(dermis) and abdomen skin were shown to be 35.93 N in KGH gel B, thereby having indicated higher value in about 3.5 times compared to control group.
Keywords
Bio-adhesiveness; Hydrogel; Hydrolysis products;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
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1 Song KB et al.: The relationships betwteen periodontal indices and oral hygiene behaviour and knowledge about periodontal l1disease after periodontal treatment. J Korean Academy of Dental Health 26(1): 101-115. 2002.
2 Back YR et al.: The effects of vitamin-C containing neutraceutical on periodontal wound healing as an adjunct to non-surgical or surgical periodontal treatment. J Korean Acad Periodontol 39(2): 151-166. 2009.   과학기술학회마을
3 Larsen T: In vitro release of Doxycycline from Bioabsorbable materials and acrylic strips. J Periodontol 61(1): 30-34. 1990.   DOI
4 Minabe Metal.: Application of a local drug delivery system to periodontal therapy: I . Development of collagen preparations with immobilized tetracycline. J Periodontol 60(2): 113-111, 1988.
5 Williams RC el aL: Altering the progression of human alveolar bone loss with the non steroidal anti-inflammatory durg flurbiprofen. J PeriodontoI 60(9): 485-490. 1989.   DOI
6 Buckley MMT. Brogden RN: Ketorolac. A review of its pharmacodynamic and Pharmacokinetic properties and therapeutic potenital. Drug 39(1): 86-109, 1990.   DOI   ScienceOn
7 Grandos-Soto V et al.: Evidence against the participation of $\mu$ and -opioid receptors in the analgesic activity of ketorolac, in rats. J Pharm Pharmacol 47(6): 514-517. 1995.   DOI   ScienceOn
8 Jeffcoat MK et al.: A comparison of topical ketorolac. systemic flurbiprofen. and placebo for the inhibition of bone loss in adult periodontitis. J Periodontol 66(5): 529-337. 1995.   DOI   ScienceOn
9 Chun MK. Kwak BT. Choi UK: Preparation of buccal patch composed of carbobol. poloxamer and hydroxypropyl methylcellulose. Arch Pharm Res 26(11): 913-978, 2003.
10 Nam HG Lee CH. Shin YH: Effect of skin penetration enhancer on the drug release from indomethacin-son hydrogel. J Kor Pharm Sci 32(1): 35-40. 2002.   과학기술학회마을
11 Akao T. Kobashi K, Aburada M: Enzymatic studies on the animal and intestinal bacterial methabolism of geniposide. Biol Pharm Bull 17(12): 1513-1516. 1994.   DOI
12 Kawata Y et al.: Formation of nitrogen containing metabolites from geniposide and gardenoside by human intestinal bacteria. Planta Med 51(6): 536-542. 1991.
13 Sung HW et al.: In vitro surface characterization of a biological patch fixed with naturally occurring crosslinking agent. Biomaterials 21(13): 1353-1362. 2000.   DOI   ScienceOn
14 Kim MJ : Skin permeation and periodontits alleviation effect of hydrogel containing ketorolac tromethamine and hydrolysis products of gardeniae fructus. J of Dental Hygiene Science 5(3): 113-117. 2005.