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http://dx.doi.org/10.7231/jon.2021.32.3.285

Long-Term Observations of Korean Medicine Treatment in Patients with Mild Cognitive Impairment: Two Case Reports  

Son, Sung-Eun (Kwang Dong Korean Medicine Hospital, Dizziness.Tinnitus Center)
Lee, Go eun (Department of Korean Rehabilitation Medicine, National Rehabilitation Center)
Lee, Na-hyun (Department of Korean Neuropsychiatry Medicine, College of Korean Medicine, Wonkwang University)
Lyu, Yeoung-Su (Department of Korean Neuropsychiatry Medicine, College of Korean Medicine, Wonkwang University)
Cheong, Moon Joo (Rare Diseases Integrative Treatment Research Institute in Wonkwang University Jangheung Integrative Medical Hospital)
Kang, Hyung Won (Rare Diseases Integrative Treatment Research Institute in Wonkwang University Jangheung Integrative Medical Hospital)
Publication Information
Journal of Oriental Neuropsychiatry / v.32, no.3, 2021 , pp. 285-302 More about this Journal
Abstract
Objectives: To examine the effect of long-term Korean medicine treatment on mild cognitive impairment (MCI). Methods: This study was conducted on two patients who were diagnosed with mild cognitive impairment and received long-term Korean medicine treatment. In order to evaluate the degree of cognitive decline, SNSB and K-MMSE were performed 2~3 times at the first visit and during the treatment process. Results: Both cases 1 and 2 were diagnosed with MCI with a high possibility of developing dementia. In case 1, MCI progressed to early dementia at one year after the diagnosis of MCI. However, in case 2, that MCI status was maintained without progressing to dementia for 4 years after the diagnosis of MCI. The cause of such difference in the course of MCI might be attributed to the fact that Case 1 had lower K-IADL level but higher SGDS level than Case 2 at the time of initial diagnosis, with weak family support and irregular herbal medicine intake. Conclusions: Korean medicine treatment could improve and manage symptoms of cognitive decline due to MCI.
Keywords
MCI; SNSB-2; Long-term Korean medicine treatment; Yisam-dan;
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1 Brodaty H, Aerts L, Crawford J, Heffernan M, Kochan N, Reppermund S, Kang K, Maston K, Draper B, Trollor J, Sachdev P, Operationalizing the diagnostic criteria for mild cognitive impairment: The salience of objective measures in predicting incident dementia, American Journal of Geriatric Psychiatry. 2017;25(5):485-97.   DOI
2 RC Petersen, R Doody, A Kurz, RC Mohs, JC Morris, PV Rabins, K Ritchie, M Rossor, L Thal, B Winblad. Current concepts in mild cognitive impairment. Archives of Neurology. 2001;58(12):1985-92.   DOI
3 Salloway S, Ferris S, Kluger A, Goldman R, Griesing T, Kumar D, Richardson S. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology. 2004;63(4):651-7.   DOI
4 Hachinski VC, Iliff LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, Russell RW, Symon L. Cerebral blood flow in dementia. Arch Neurol. 1975;32(9):632-7.   DOI
5 Geslani DM, Tierney MC, Herrmann N, Szalai JP. Mild cognitive impairment:an operational definition and its conversion rate to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 2005;19(5-6):383-9.   DOI
6 Jung ES, Lee JH, Kim HT, Park SS, Kim JE, Cha JY, Seol IC, Choi YE, Yoo HR. Effect of acupuncture on patients with mild cognitive impairment assessed using functional near-infrared spectroscopy on week 12 (close-out): a pilot study protocol. Integr Med Res. 2018;7(3):287-95.   DOI
7 Fischer P, Jungwirth S, Zehetmayer S, Weissgram S, Hoenigschnabl S, Gelpi E, Krampla W, Tragl KH. Convertsion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology. 2007;68(4):288-91.   DOI
8 Choi YJ, Kim YE, Jerng UM, Kim H, Lee SI, Kim GN, Cho SH, Kang HW, Jung IC, Han KS, Lee JH. Korean Traditional Medicine in Treating Patients with Mild Cognitive Impairment: A Multicenter Prospective Observational Case Series. Evidence-Based Complementary and Alternative Medicine. 2020;1-12.
9 Park KA, Choi JW, Jeon JK, Kim KS, Park KW. Different Performances on a Confrontational Naming Test in Patients with Alzheimer's Disease and Mild Cognitive Impairment. J Korean Geriatr Soc. 2011;15(3):135-43.   DOI
10 Kim WY, Jeon WK, Heo EJ, Park SY, Han CH. Literature Review and suggestions : dementia clinical studies in Korean Oriental Medicine. Korea J oriental medicine. 2011;17(2): 39-46.
11 Jang GB. Korean translation of Kyungakjeinseo. Seoul: Iljungsa. 1992:846.
12 Ozkan S, Demet OA, Nese TE, Didem A. Apraxia for differentiating Alzheimer's disease from subcortical vascular dementia and mild cognitive impairment. Neuropsychiatr Dis Treat. 2013;9:947-51.   DOI
13 Kim BM, Jo HG, Kang HW, Choi SY, Song MY, Sul JUl. Proposal of East-West Integrative Medicine Manual for Mild Cognitive Impairment in a Korean Medicine Hospital. J of Oriental Neuropsychiatry. 2018;29(4):239-53.   DOI
14 Jelic V, Darrhe-Shori T. Donepezil A Review of Pharmacological Characteristics and Role in the Management of Alzheimer Disease. Clinical Medicine Insights: Therapeutics 2010:2 771-88.
15 Petersen RC. Mild cognitive Impairment. Continuum. 2016;22(2):404-18.   DOI
16 Korean Psychosomatic Society. Psychosomatic medicine. Paju: Jipmoondang. 2007;324-33.
17 Korolev IO. Alzheimer's Disease: A clinical and Basic Science Review. Medical Student Research Journal. 2014;4:24-33.
18 Luck T. Luppa M, Wiese B, Maier W, Bussche H, Eisele M, Jessen F, Weeg D, Weyerer S, Penrtzek M, Leicht H, Koehler M, Tebarth F, Olbrich J, Eifflaender-Gorfer S, Fuchs A, Koening HH, Riedel-Heller SG. Prediction of incident dementia: impact of impairment in instrumental activities of daily living and mild cognitive impairment-results from the German study on ageing, cognition, and dementia in primary care patients. Am J Geiatr Psychiatry. 2021;20(11):943-54.
19 Kim TY, Ko DK, Sohn JH, Kim JY, Lee DH, Jeon HJ, chang SM, Lee YR, Choi JH, Yoon HK, Cho MJ. The Conversion Rates Difference to the Alzheimer Dementia between the Normal Elderly Group and the Mild Cognitive Impairment Group in One Community Cohort:18 Months' Prospective Follow-up Study. J Korean Assoc Soc Psychiatry. 2008;13(1):10-6.
20 U Ghafoor, Lee JH, Hong KS, Park SS, Kim JE, Yoo HR. Effects of Acupuncture Therapy on MCI patients Using Functional Near-Infrared Spectroscopy. Frontiers in Aging Neuroscience. 2019;11:237.   DOI
21 Kang SJ, Choi SH, Lee BH, Kwon JC, Na DL, Han SH. The reliability and validity of the Korean Instrumental Activities of Daily Living(K-IADL). J. Korean Neurol. Assoc. 2002;20(1):8-14.
22 Rountree SD, Waring SC, Chan WC, Lupo PJ, Darby EJ, Doody RS. Importance of subtle amnestic and nonamnestic deficits in mild cognitive impairment: prognosis and conversion to dementia. Dement Geriatr Cogn Disord 2007;24(6):476-82.   DOI
23 Tabert MH, Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, Zamora D, Goodkind M, Bell K, Stern Y, Devanand DP. Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Arch Gen Psychiatry. 2006;63(8):916-24.   DOI
24 Ge S, Wu B, Bailey DE Jr, Dong X. Social support, social strain, and cognitive function among community-dwelling U.S. Chinese Older Adults. J Gerontol A Biol Sci Med Sci. 2017;72(1):16-21.   DOI
25 Kim WJ, Yang DW, Shon YM, Shim YS, Cho H, Kim BS, Kim YI, Lee KS. Neuropsychological Differences between Mild Cognitive Impairment and Mild Alzheimer's Disease. Dementia and Neurocognitive Disorders. 2006;5:12-7.
26 Kim WY, Han CH, Heo EJ, Kang HW, Jeon WK. A review of non-pharmacological intervention efficacy in patients with mild cognitive impairment. Journal of Oriental Neuropsychiatry. 2011;22(3):1-11.   DOI
27 Lee SY, Yoon SY, Kim MJ, Lee HY, Lyu CW, Jang GH. Investigation of the Correlation between Seoul Neuropsychological Screening Battery Scores and the Gray Matter Volume after Correction of Covariates of the Age, Gender, and Genotypes in Patients with AD and MCI. Journal of the Korean society of magnetic resonance in medicine. 2013;17(4):294-307.   DOI
28 Kang HW, Kim ST, Son HJ, Han PL, Cho HK, Lee YJ, Lyu YS. Standardization of Quality and Inhibitory Effect of Alzheimer in Aβ Oligomer-induced H19-7 Cells by LMK02. Korean Journal of Oriental Physiology & Pathology. 2009;23(2):397-404.
29 Lim SJ. Gugijihwang-Tang (PM012) decreases cognitive impairment and promotes neurogenesis in the 3xTg AD transgenic mice. Seoul; Kyung Hee university; 2014.
30 Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, Dyck CH, Thal LJ. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352(23):2379-88.   DOI
31 Min B, Suijun T, Zhaoxu Z, Qilin M, Shiyang Z, Zuomin L, Yidan Z, Xuling L, Desheng W. Changes in cerebral glucose metabolism in patients with mild-to-moderate Alzheimer's disease: a pilot study with the Chinese herbal medicine fuzhisan. Neurosci Lett 2011;501(1):35-40.   DOI
32 Lee DY, Kim JB, Ha DJ, Kwon CY. Classical, Non-Clinical, and Clinical Evidence of Yokukansan for Alleviating Aggression: Scoping Review. J of Oriental Neuropsychiatry. 2021;32(2):111-27.   DOI
33 Kang SJ, Choi SH, Lee BH, Jeong Y, Hahm DS, Han IW, Cummings JL, Na DL. Caregiver-Administrered Neuropsychiatric Inventory (CGA-NPI). J Geriatri Psychiatry Neurol. 2004;17(1):32-5.   DOI
34 Lee GE, Moon KS, Kim NK, Chung SY, Jung IC, Kang HW. Preliminary Study to Develop the Korean Medical Pathologic Aging Scale and Korean Medical Pattern Identification for Dementia. J Korean Med. 2017;38(3):111-23.   DOI
35 Rozzini L, Costardi D, Chilovi BV, Franzoni S, Trabucchi M, Padovani A. Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. International Journal of Geriatric Psychiatry. 2007;22(4):356-60.   DOI
36 Petersen RC, Morris JC. Clinical features. In: Petersen RC, ed. Mild Cognitive Impairment: Aging to Alzheimer's Disease. New York: Oxford university Press, Inc, 2003;15-40.
37 Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, Ivnik RJ, Smith GE, Jack Jr CR. Mild cognitive impairment: ten years later. Arch Neurol. 2009;66(12):1447-55.   DOI
38 Choi YJ, Kim YE, Jerng UM, Kim H, Lee SI, Kim GN, Cho SH, Kang HW, Jung IC, Han KS, Lee JH. Korean Traditional Medicine in Treating Patients with Mild Cognitive Impairment: A Multicenter Prospective Observational Case Series. Evidence-Based Complementary and Alternative Medicine. 2020:1-12.
39 Modrego PJ, Ferrandez J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type:a prospective cohort study. Arch Neurol. 2004;61:1290-3.   DOI
40 Doody RS, Ferris SH, Salloway S, Sun Y, Goldman R, Watkins WE, Xu Y, Murthy AK. Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology. 2009;72(18):1555-61.   DOI