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http://dx.doi.org/10.7231/jon.2020.31.4.301

A Study on the Combination Effect of Herbal Medicine and Western Medicine on BPSD in Patients with Alzheimer's Disease: A Systematic Review  

Kim, Man-Gi (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University)
Chang, Seok-Joo (Department of Pediatrics, College of Korean Medicine, Dongguk University)
Hong, Min-Ho (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University)
Kim, Geun-Woo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University)
Koo, Byung-Soo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University)
Publication Information
Journal of Oriental Neuropsychiatry / v.31, no.4, 2020 , pp. 301-314 More about this Journal
Abstract
Objectives: The purpose of this study was to provide clinical evidence to support the use of herbal medicine combined with western medicine for BPSD. Methods: Studies were identified by searching CNKI, Pubmed, EMBASE, Cochrane Library, SCIENCEON, RISS, KMbase, KISS, OASIS. Literature searches of Chinese, English, and Korean databases were performed. Two authors independently extracted the data and evaluated the quality of each study. Results: The literature search identified 203 articles. Of these, 7 were selected for the analysis. The risk of bias in most studies was unclear. The most frequently used diagnostic tools were the NINCDS-ADRDA and DSM-IV. The most commonly used results indicator was NPI. In 6 of the 7 papers, combination treatment (herbal & Western medicine) was statistically significantly more effective than single treatment (Western medicine alone) for BPSD. No significant adverse events were reported. Conclusions: Herbal medicine in combination with Western medicine is more effective for treating BPSD than Western medicine alone. However, the quality of the studies used in this study was uncertain and the sample size was too small. Based on the findings of this study, more high-quality clinical trials are needed to confirm the efficacy of combination treatment.
Keywords
BPSD; Behavioral and Psychological Symptoms of Dementia; Herbal medicine; Combined therapy;
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Times Cited By KSCI : 6  (Citation Analysis)
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1 Chakraborty S, Lennon JC, Malkaram SA, Zeng Y, Fisher DW, Dong H. Serotonergic system, cognition, and BPSD in Alzheimer's disease. Neuroscience Letters. 2019;21: 36-44.
2 Han SH. Behavioral and Psychological Symptoms of Dementia: An Overview. Dementia and Neurocognitive Disorders. 2004;3:1-4.
3 Cho KH, Kim TH, Jin C, Lee JE, Kwon SW. The Literary Trends of Herbal Prescription Ukgan-san and its Application in Modern Traditional Korean Medicine. Journal of Korean Medicine. 2018;39(3):17-27.   DOI
4 Japanese Society of Neurology. Clinical Practice Guidelines Containing Kampo Product in Japan. Task Force for Clinical Practice Guidelines(CPG-TF) Committee for EBM. 2019.
5 Singh S, Srivastav S, Castellani R, Plascencia-Villa G, Perry G. Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders. Neurotherapeutics. 2019;16(3):666-74.   DOI
6 Savaskan E, Mueller H, Hoerr R, Gunten A, Gauthier S. Treatment effects of Ginkgo biloba extarct EGb 761 on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials. International Psychogeriatrics. 2018;30(3):285-93.   DOI
7 Han WJ, Kim HS, Kim ST, Kim TH, Lee YS, Kang HW. Comparative effects of Radix Polygalae and Rhizoma Acori Graminei on CT105-induced neuroblastoma cell lines. Journal of oriental neuropsychiatry. 2003;14(2):95-105.
8 Korean Neuropsychiatric Association. Textbook of neuropsychiatry. iMiS COMPANY. 2016;588-9.
9 Korean Neuropsychiatric Association. Textbook of neuropsychiatry. iMiS COMPANY. 2016;795.
10 Choi SH. Assessment Scale for Behavioral and Psychological Symptoms of Dementia. Dementia and Neurocognitive Disorders. 2004;3:9-13.
11 Lin S, Tsai Y, Lai J, Wu C. Demographic and medication characteristics of traditional Chinese medicine users among dementia patients in Taiwan:A nationwide database study. Journal of Ethnopharmacology. 2015;23:108-15.
12 Park UJ. Trends Analysis of Characteristics in Patient with Dementia. Journal of the Korea Academia-Industrial cooperation Society. 2017;18(1):202-9.   DOI
13 Kim CH. Behavioral Disturbances in BPSD. Korean Association for Geriatric Psychiatry. 2000;4(1):17-23.
14 Korean Neuropsychiatric Association. Textbook of neuropsychiatry. iMiS COMPANY. 2016;581.
15 Fiest KM, Roberts JI, Maxwell CJ, Hogan DB, Smith EE, Frolkis A, Cohen A, Kirk A, Pearson D, Pringsheim T, Venegas-Torres A, Jette N. The Prevalence and Incidence of Dementia Due to Alzheimer's Disease: a Systematic Review and Meta- Analysis. Canadian Journal of Neurological Sciences. 2016;43(Suppl 1):S51-82.
16 Bessey LJ, Walaszek A. Management of Behavioral and Psychological Symptoms of Dementia. Current Psychiatry Reports. 2019;21(8):66.   DOI
17 The Textbook Compilation Committee of Neuropsychiatry of Oriental Schools in Nation. The Neuropsychiatry of Oriental Medicine 3rd Edition. Jipmoondang. 2018;319-27.
18 Lee DH, Analysis of Clinical Korean Medicine Studies on Dementia : Focused on Korean Literatures for 10 Years. Journal of Society of Preventive Korean Medicine. 2020; 24(1):37-48.
19 Yoon KJ, Lee AY, Kim HS, Choi JH, Lee JA, Kim NK, Hwang DK, Lee SY. Evaluation and study of the 2nd stage pilot project in collaboration with western medicine and oriental medicine. Korea Institute for Health and Social Affairs. 2018;3-10.
20 Han M. Clinical Observation on Jianwei Yunao Decoction in Treating for Alzheimer's Disease with Qi and Blood Deficiency Syndrome. Acta chinese medicine. 2018;33: 878-81.
21 Ringman J, Frautschy S, Teng E, Begum A, Bardens J, Beigi M, Gylys K, Badmaev V, Heath D, Apostolova L, Porter V, Vanek Z, Marshall G, Hellemann G, Sugar C, Masterman D, Montine T, Cummings J, Cole G. Oral curcumin for Alzheimer's disease:tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimer's Research&Therapy. 2012;4(5):43.   DOI
22 Hyde A, May B, Dong L, Feng M, Liu S, Guo X, Zhang A, Lu C, Xue C. Behavioural and psychological symptoms of dementia(BPSD): A systematic review and meta-analysis. Journal of Psychopharmacology. 2017;31(2):169-83.   DOI
23 Yoon KJ, Lee AY, Kim HS, Choi JH, Lee JA, Kim NK, Hwang DK, Lee SY. Evaluation and study of the 2nd stage pilot project in collaboration with western medicine and oriental medicine. Korea Institute for Health and Social Affairs. 2018;30-36.
24 Kim JH, Kim SK, Han JM, Yea SJ, Kim C, Jang HC, Song MY. Analysis of Studies on Combined Medication of the Oriental and the Western Medicines. The Journal of Oriental Medical Preventive. 2009;13(3):1-18.
25 Lin Y, Chu W, Tang Y. Clinical Observation of Aripiprazole Combined with Fufang Haishe Capsule in Treating Alzheimer's Disease. Journal of New Chinese Medicine. 2016;48(12): 26-7.
26 Pan W, Wang Q, Kwak S, Song Y, Qin B, Wang M, Yamamoto Y. Shen-Zhi-Ling Oral Liquid Improves Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine. 2014:1-6.
27 Okahara K, Ishida Y, Hayashi Y, Inoue T, Tsuruta K, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Yoshida K, Noda S, Tomita S, Fujimoto M, Hosomi J, Mitsuyama Y. Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease. Progress in Neuro-Psychopharmacology&Biological Psychiatry. 2010;34:532-6.   DOI
28 Monji A, Takita M, Samejima T, Takaishi T, Hashimoto K, Matsunaga H, Oda M, Sumida Y, Mizoguchi Y, Kato T, Horikawa H, Kanba S. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2009;33:308-11.   DOI
29 Yancheva S, Ihl R, Nikolova G, Panayotov P, Schlaefke S, Hoerr R. Ginkgo biloba extract EGb 761, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: A randomised, doubleblind, exploratory trial. Aging&Mental Health. 2014;13(2): 183-90.   DOI