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http://dx.doi.org/10.7231/jon.2019.30.2.071

A Review of the Korean Experimental Studies on the Antidepressant Effect of Herbal Medicines  

Han, Da-Young (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University)
Kim, Sang-Ho (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University)
Chung, Dae-kyoo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University)
Publication Information
Journal of Oriental Neuropsychiatry / v.30, no.2, 2019 , pp. 71-88 More about this Journal
Abstract
Objectives: The present study aims to review the antidepressant effect of herbal medicines reported in Korean local journals. Methods: We searched in electronic databases (Koreantk, KISS, OASIS, NDSL) for studies, published in Korean national journals, that assessed herbal medicine effect of depression model. The search term was 'depression' in the abstract or whole text. Depression model, herbal material, experimental results, mechanisms were extracted. Results: We included 43 articles in which 38 studies were in vitro experiments, and the rest 5 were in vivo experiments. The most common experiment subject model was a rat and the most widely used method to induce depression was Despair behavior test. 21 studies used simple herbal medicines, and 22 studies used complex herbal medication. Glycyrrhizae Radix was the most commonly used herbal material to improve depression model. The most common mechanisms of herbal medicine with antidepressant effect were inhibition of Monoamine activation mechanism and depression related neurohormone secretion. Conclusions: Herbal medicines may be a promising resource for treating depression.
Keywords
Depression; Depressive disorder; Herbal medicine; Antidepressant; Review;
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Times Cited By KSCI : 22  (Citation Analysis)
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