Browse > Article
http://dx.doi.org/10.7231/jon.2014.25.2.191

The Anti-Depressive Effects of BanHaHuBakTang-kami (BHHBT) after Chronic Immobilization Stress in C57BL/6 Mice  

Kim, Kook-Ki (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Lee, Sang-Ryong (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Jung, In-Chul (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Oriental Neuropsychiatry / v.25, no.2, 2014 , pp. 191-202 More about this Journal
Abstract
Objectives: The purpose of this study was to examine the anti-depressive effects of BanHaHuBakTang-kami (BHHBT) on an animal model of depression induced by chronic immobility stress. Methods: Mice were treated daily with immobilization stress for 2 hours over a period of 21 days. To examine the effect of BHHBT, we performed behavioral, biochemical and histological analysis to measure immobility time (FST), brain neurotransmitter concentration (HPLC, ELISA), hippocampal damage (H&E staining) and CRF-R1 expression (immunohistochemistry). Results: BHHBT has reduced the immobility time of immobilization stress exposed mice in the forced swimming test. BHHBT has increased the amount of serotonin in the brain. BHHBT has increased the expression level of serotonin in the brain. BHHBT 540 mg/kg were sufficient to prevent tissue damage in the hippocampus region. BHHBT has reduced the expression level of CRF receptors in the hippocampus region. Conclusions: These results suggest that BHHBT may have anti-depressive effects on mice treated with immobilization stress by reducing immobility, increasing brain serotonin concentration and reducing CRF-R1 expression in the hippocampus region.
Keywords
BanHaHuBakTang-kami (BHHBT); Immobilization stress; Anti-depressive effect; Depression; Serotonin;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Wrase J, Reimold M, Puls I, Kienast T, Heinz A. Serotonergic dysfunction: brain imaging and behavioral correlates. Cogn Affect Behav Neurosci. 2006;6:53-61.   DOI   ScienceOn
2 Woon FL, Sood S, Hedges DW. Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1181-8.   DOI   ScienceOn
3 Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Pineyro G, Sadikot AF, Debonnel G. Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron. 2007;55(5):712-25.   DOI   ScienceOn
4 Lorenzetti V, Allen NB, Fornito A, Yuel M. Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies. J Affect Disord. 20091;17:1-17.   DOI   ScienceOn
5 McKinnon MC, Yucel K, Nazarov A, MacQueen GM. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci. 2009;34:41-54.
6 Lee IA, Yoganarasimha D, Rao G, Knierim JJ. Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature. 2004;430(6998):456-9.   DOI   ScienceOn
7 Aubry JM, Pozzoli G, Vale WW. Chronic treatment with the antidepressant amitriptyline decrease CRF-R1 receptor mRNA levels in the rat amygdala. Neurosci Lett. 1999;266:197-200.   DOI   ScienceOn
8 Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature. 2008;455(7215):894-902.   DOI   ScienceOn
9 Zobel AW, Nickel T, Kunzel HE, Ackl N, Sonntag A, Ising M, Holsboer F. Effects of the high-affinity corticotropin- releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res. 2000;34(3):171-81.   DOI   ScienceOn
10 Lee TH, Lee SJ, Huh J, Shin DG, Lee JC, Shin YS, Yun YG. Study on the Applications of prescriptions including Platycodi Radix as a main component in Dongeuibogam. The Korean journal of oriental medical prescription. 2010;18(1):23-42.   과학기술학회마을
11 Ryu SH, Lim YH, Ryou SY, Yun YG. A study on Applications of prescriptions including Fructus Ponciri Seu Aurantii as a main component in Dongeuibogam. The Korean journal of oriental medical prescription. 2008;16(1):15-27.   과학기술학회마을
12 Ganguly, S., Coon, S. L. and Klein, D. C. Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell Tissue Res. 2002;309:127-37.   DOI   ScienceOn
13 Willner P. The validity of animal models of depression. Psychopharmacology. 1984;83(1):1-16.   DOI
14 Rodrigues AL, da Silva GL, Mateussi AS, Fernandes ES, Miguel OG, Yunes RA, Calixto JB, Santos AR. Involvement of monoaminergic system in the antidepressantlike effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life sciences. 2002;70(12):1347-58.   DOI   ScienceOn
15 Korf, H. W., Schomerus, C. and Stehle, J. H. The pineal organ, its hormone melatonin and the photoneuroendocrine system. Adv Anat Embryol Cell Biol. 1998;146:1-100.   DOI
16 Partonen, T. Extrapineal melatonin and exogenous serotonin in seasonal affective disorder. Med Hypotheses. 1998;51:441-2.   DOI   ScienceOn
17 Wetterberg, L. Melatonin and affective disorders. Ciba Found Symp. 1985;117:235-65.
18 Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med. 2009;60:355-66.   DOI   ScienceOn
19 Yuk CS. Hyeondae bangyakhappyeon. Gyechuk munhwasa. 1976:200.
20 Naito T, Itoh H, Takeyama M. Effect of Hange-koboku-to (Banxia-houpo-tang) on an plasma and saliva. Biol Pharm Bull. 2003;26(11):1609-13.   DOI   ScienceOn
21 Lee BK, Cho TS. Experimental Studies on Pharmacological Action of the Banhahubagtang, A Combined Preparation of Oriental Medicine. Kor J Pharmacogn. 1987;18(1):14-25.   과학기술학회마을
22 Weiyun Z, Jianmei L, Jixiao Z, Zhenqiu S, Yong W, Lingdong K. Chinese medicine Banxia-houpu decoction regulates c-fos expression in the brain regions in chronic mild stress model in rats. phytother Res. 2004;18(3):200-3.   DOI   ScienceOn
23 Kuribara H, Kishi E, Hattori N, Okada M, Maruyama Y. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol. 2000;52(11):1425-9.   DOI
24 Luo L. Nong Wang J, Kong LD, Jiang QG, Tan RX. Antidepressant effect of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula. J Ethnopharmacol. 2000;73(1-2):277-81.   DOI   ScienceOn
25 Guo Y, Kong L, Wang Y, Huang Z. Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia-houpu decoction. Phytother Res. 2004;18(3):204-7.   DOI   ScienceOn
26 Ju YS. Ungok Herbology. Jeonju:Woosuk Press. 2013:819, 826-8. Korean.
27 Oh G. Uijong-geumgam. Korea medical book publisher. 1963.
28 Ministry for Health, Welfare and Family Affairs. The Epidemiological Survey of Mental Disorders in Korea. 2011. Available from:URL:http://www.mw.go.kr/front_new/jb/sjb030301vw.jsp?PAR_MENU_ID=03&MENU_ID=031604&CONT_SEQ=274852&page=1
29 Korea Institute of Oriental Medicine. Standardization and Unification of the Terms and Conditions Used for Diagnosis in Oriental Medicine (III). J Korean Oriental Med. 1997;3(1):41-65.   과학기술학회마을
30 The Textbook Compliation Committee of Neuropshychiatry of Oriental Schools in Nation. The Neuropsychiatry of Oriental Medicine. Seoul: Jipmoon-Dang. 2007;256-65, 295, 472, 474-8.
31 Min SG. Modern Psychiatry, 5th Edition. Seoul:Ilchokak. 2006;52-67, 274-97, 323-58, 743-56.
32 Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289:3095-105.   DOI   ScienceOn
33 Statistics korea. The cause of death statistics. Statistics korea. 2010.
34 Choi EM, Koo SJ. Possibility of regulation by food in depression and mood disorders. Food science and industry. 2001;34(4):53-69.
35 Bear MF, Connors BW, Paradiso MA. Neuroscience: Exploring the Brain, 3rd Edition. Seoul: Biomedibook. 2009.
36 Kang HW, Jang HH, Kang IS, Moon HC, Hwang YJ, Lyu YS. A Study on The Oriental-medical Understanding of Depression. Journal of oriental neuropsychiatry. 2011;12(2):1-15.   과학기술학회마을
37 Hwang WW, Kim JH. Dong ui jeong sin ui hag. Seoul: Hyundai uihag seojeogsa. 1987:505-29, 607-11.
38 Lee SI. Oriental Prescriptionology. Seoul: Younglim Press. 1999:382.
39 Zhang ZJ. Chin Kuei Yao Lueh. Seoul. Daesung Press. 1993;66.
40 Park SS, Yeom TH. Hyeondae hanbang gangjwa. Geumgang Publisher. 1963:118.
41 Heo J. Dong ui bo gam. Namsungdang. 1966:30.
42 Kendler KS, Gardner CO, Neale MC, Prescott CA. Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?. Psychol Med. 2001;31:605-16.
43 Brown, G. M. Melatonin in psychiatric and sleep disorders: therapeutic implication. CNS Drugs. 1995;3:209-26.   DOI