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http://dx.doi.org/10.7231/jon.2013.24.3.263

Effects of Galgunhaejutang on Alcohol Consumption in C57BL/6 Mice

Cho, Seung-Hun (Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Medical Center)
Kim, Hyeun-Kyeung (Medical Research Institute, Pusan National University)
Kim, Jong-Woo (Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Hospital at Gangdong)
Whang, Wei-Wan (Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Medical Center)
Kim, Sung-Gon (Department Psychiatry, Pusan National University Yangsan Hospital)

Publication Information

Journal of Oriental Neuropsychiatry / v.24, no.3, 2013 , pp. 263-270 More about this Journal

Abstract

Objectives : Galgunhaejutang extract (GHT) is a Traditional Korean medical herbal mixture that has been tradtionally used to treat alcohol consumption. This study was preformed to evaluate the effects of GHT on alcohol consumption in C57BL/6 mice. Methods : Sixty three C57BL/6 mice were alcohol dependence-induced by limited access paradigm. Water, GHT 0.688 g/kg (GHT-L), or GHT 3.45 g/kg (GHT-H) were administrated for 10 days. The amounts of alcohol consumption for 2 hours, water consumption for 22 hours, food intake for 24 hours and body weight were measured. Results : There weren't significant differences in 2 hours of alcohol consumption, 22 hours of water consumption, 24 hours of food intake and body weight for ten days between vehicle group and GHT-L or GHT-H group. Conclusions : Further studies employing multi-dose and long term administration of GHT (more than 10 days) might be of benefit.

Keywords

Korean traditional medicine; Herbal mixture; Alcohol consumption; C57BL/6;

Citations & Related Records

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