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http://dx.doi.org/10.7231/JON.2012.23.2.021

Single Oral Dose Toxicity Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rat  

Choi, Woo-Chang (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Jung, In-Chul (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Lim, Jong-Soon (Dept. of Life Science and Preventative Medicine College of Oriental Medicine, Dae-Jeon University)
Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Dae-Jeon University)
Lee, Sang-Ryong (Dept. of Life Science and Preventative Medicine College of Oriental Medicine, Dae-Jeon University)
Publication Information
Journal of Oriental Neuropsychiatry / v.23, no.2, 2012 , pp. 121-128 More about this Journal
Abstract
Objectives : This research investigates the single oral dose toxicity of ACM in SD rats. Methods : ACMs were administered to female and male SD rats, as an oral dose of 5000 mg/kg. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. Results : We could not find any mortality. Compared with the control group, significant weight change was not observed in the experimental group. First day after administration, compound-colored stool was observed in all rats. After the second day of administration, the more common symptoms were not observed. There were no gross abnormalities in all cases. [ED NOTE: highlight: given the context, this is very vague] Conclusions : The results obtained in this study suggest that the approximate lethal dose of ACM in both female and male rats were considered as over 5000 mg/kg.
Keywords
ACM; Added Chongmyung-Tang; single oral dose toxicity; SD rats;
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Times Cited By KSCI : 8  (Citation Analysis)
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