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http://dx.doi.org/10.7231/JON.2012.23.1.145

The Effects of Jeoreongchajeonja-tang(Zhulingjuqianzi-tang) on the βA and LPS Induced BV2 microglial cell  

Ryu, Chang-Hee (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Jung, In-Chul (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Lee, Sang-Ryong (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Oriental Neuropsychiatry / v.23, no.1, 2012 , pp. 145-159 More about this Journal
Abstract
Objectives : This research investigates the effect of the JCT extract regarding Alzheimer's disease. Methods : The effects of the JCT extract on IL-$1{\beta}$, IL-6, TNF-${\alpha}$, COX-2, NOS-II mRNA, APP mRNA, BACE mRNA, Nitric oxide(NO), and ${\beta}A$ protein production in the BV2 microglia cell lines treated with LPS and ${\beta}A$ were investigated. Results : 1. The JCT extract suppressed the expression of IL-$1{\beta}$, IL-6, TNF-${\alpha}$, COX-2, and NOS-II mRNA in BV2 microglial cell line treated with LPS and ${\beta}A$. 2. The JCT extract suppressed the expression of BACE and APP mRNA in BV2 microglial cell line treated with LPS and ${\beta}A$. 3. The JCT extract suppressed the expression of Nitric oxide(NO) in BV2 microglial cell line treated with LPS and ${\beta}A$. 4. The JCT extract suppressed the expression of ${\beta}A$ protein production in BV2 microglial cell line treated with LPS and ${\beta}A$. Conclusions : These results suggest that the JCT group may be effective for the treatment of Alzheimer's disease. Thus, JCT could be considered among the future therapeutic drugs indicated for the treatment of Alzheimer's disease.
Keywords
alzheimer's disease; Jeoreongchajeonja-tang(Zhulingjuqianzi-tang); lipopolysacchride(LPS); ${\beta}$-amyloid(${\beta}A$);
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