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http://dx.doi.org/10.7231/JON.2012.23.1.115

Preventive Effects of Santalum album L. Extracts on Oxidation, Platelet Aggregation and Thrombosis  

Sung, Yung-Wei (Dept. of Neuropsychiatry, College of Oriental Medicine, Dong-Guk University)
Lee, Ji-Hyun (Dept. of Neuropsychiatry, College of Oriental Medicine, Dong-Guk University)
Song, Kyoo-Ju (Dept. of Neuropsychiatry, College of Oriental Medicine, Dong-Guk University)
Koo, Byung-Soo (Dept. of Neuropsychiatry, College of Oriental Medicine, Dong-Guk University)
Kim, Geun-Woo (Dept. of Neuropsychiatry, College of Oriental Medicine, Dong-Guk University)
Publication Information
Journal of Oriental Neuropsychiatry / v.23, no.1, 2012 , pp. 115-128 More about this Journal
Abstract
Objectives : To evaluate the in vitro scavenging activity, inhibitory effect of LDL oxidation of pro-oxidant reactive species, anti-platelet aggregative effects and anti-thrombosis effects in response to treatment with SA using various screening methods including biological and non-biological oxidants. Methods : The antioxidant activity concerning extract from SA was studied with in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on $Cu^{2+}$-induced human LDL oxidation and the inhibitory effect on thrombin-induced platelet aggregation and thrombosis. Results : SA extracts were found to have a potent scavenging activity regarding oxidative stress as well as an inhibitory effect towards LDL oxidation, platelet aggregation, and thrombosis. Conclusions : The SA extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis.
Keywords
Santalum album L.; Oxidation; Platelet aggregation; Thrombosis;
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Times Cited By KSCI : 5  (Citation Analysis)
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