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Effects of Tianwangbuxin-dan, Wendan-tang, Guipi-tang on the expression of MT1 and MT2 melatonin receptors in C6 glial cells  

Cho, Yun-Song (Dept. of Neuropsychiatry, Undergraduate school of Oriental Medicine, Dong-Eui University)
Kim, Bo-Kyung (Dept. of Neuropsychiatry, Undergraduate school of Oriental Medicine, Dong-Eui University)
Publication Information
Journal of Oriental Neuropsychiatry / v.21, no.2, 2010 , pp. 103-123 More about this Journal
Abstract
Objectives : This study was to investigate the effect of several herbal prescriptions such as Tianwangbuxindan qu zhusha, Tianwangbuxindan, Wendantang, Guipitang on the level of $MT_1$ and $MT_2$ melatonin receptors in C6 glial cells. Methods : For this study, we exposed of C6 cells to several herbal prescriptions resulted in non-cytotoxic in various dose as measured by MTT assay, trypan blue count, morphology change and DAPI stain. Results : Tianwangbuxindan qu zhush and Tianwangbuxindan induced the levels of $MT_1$ melatonin receptor expression in a dose-dependent manner without altering the level of $MT_2$ melatonin receptor expression. However, the treatment with Wendantang, Guipitang don't effect of $MT_1$ and $MT_2$ melatonin receptor expression. Conclusions : This results suggest that Tianwangbuxindan can be a promising the regulation of melatonin receptor synthesis, and further studies will be needed to clarify the mechanism.
Keywords
Tianwangbuxin-dan qu zhusha; Tianwangbuxin-dan; Wendan-tang; Guipi-tang; $MT_1$ and $MT_2$ melatonin receptors;
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