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Effects of Korean Mountain Ginseng Leaves and Its Active Constituents on Scopolamine-induced Amnesia in Mouse  

Kim, Ju-Bong (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University)
Kim, Soo-Hyun (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University)
Park, Sun-Young (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University)
Chung, Dae-Kyoo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University)
Publication Information
Journal of Oriental Neuropsychiatry / v.21, no.1, 2010 , pp. 125-144 More about this Journal
Abstract
Objectives: The purpose of this study was to characterize the effect of the fraction of Korean mountain ginseng folium (FKG) on the learning and memory impairments induced by scopolamine. Methods: The memory ameliorating effect of FKG was investigated using a passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine(1mg/kg, i.p.). Results: FKG (2 or 4mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance test and the Y-maze test(P<0.05), and also improved escape latency in the Morris water maze test at 2 or 4mg/kg(P<0.05). Although FKG has little inhibitory activity for AChE (IC50 value; 1847 ${\mu}g/ml$) in an invitro study, phosphorylated extracellular signal-regulated kinase(pERK) was increased by the administration of FKG inhippocampus on immunohistochemistry. Conclusions: These results suggest that FKG may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via activation of ERK pathway.
Keywords
Korean Mountain Ginseng; Memory; Extracellular signal-regulated kinase; Scopolamine; Acetylcholine esterase activity; Immunihistochemistry;
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