Browse > Article
http://dx.doi.org/10.5090/jcs.22.056

Ex Vivo Lung Perfusion in Lung Transplantation  

Haam, Seokjin (Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine)
Publication Information
Journal of Chest Surgery / v.55, no.4, 2022 , pp. 288-292 More about this Journal
Abstract
Ex vivo lung perfusion (EVLP) is a technique that enables active metabolism of the lung by creating an environment similar to that inside the body, even though the explanted lungs are outside the body. The EVLP system enables the use of lung grafts that do not satisfy the acceptance criteria for lung transplantation (LTx) by making it possible to evaluate the function of the lung grafts and repair lungs in poor condition, thereby reducing the waiting time of patients requiring LTx and consequently mortality.
Keywords
Lung transplantation; Donor pool; Ex vivo lung perfusion;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Rega FR, Vanaudenaerde BM, Wuyts WA, et al. IL-1beta in bronchial lavage fluid is a non-invasive marker that predicts the viability of the pulmonary graft from the non-heart-beating donor. J Heart Lung Transplant 2005;24:20-8.   DOI
2 George TJ, Arnaoutakis GJ, Beaty CA, et al. A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform. J Surg Res 2013;183:75-83.   DOI
3 Dong B, Stewart PW, Egan TM. Postmortem and ex vivo carbon monoxide ventilation reduces injury in rat lungs transplanted from non-heart-beating donors. J Thorac Cardiovasc Surg 2013;146:429-36.   DOI
4 Grimm JC, Zhang F, Magruder JT, et al. Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury. J Surg Res 2017;210:78-85.   DOI
5 de Perrot M, Bonser RS, Dark J, et al. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: donor-related risk factors and markers. J Heart Lung Transplant 2005;24:1460-7.   DOI
6 Cypel M, Sato M, Yildirim E, et al. Initial experience with lung donation after cardiocirculatory death in Canada. J Heart Lung Transplant 2009;28:753-8.   DOI
7 Machuca TN, Cypel M, Bonato R, et al. Safety and efficacy of ex vivo donor lung adenoviral IL-10 gene therapy in a large animal lung transplant survival model. Hum Gene Ther 2017;28:757-65.   DOI
8 Andreasson AS, Dark JH, Fisher AJ. Ex vivo lung perfusion in clinical lung transplantation: state of the art. Eur J Cardiothorac Surg 2014;46:779-88.   DOI
9 Steen S, Liao Q, Wierup PN, Bolys R, Pierre L, Sjoberg T. Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo. Ann Thorac Surg 2003;76:244-52.   DOI
10 Cypel M, Rubacha M, Yeung J, et al. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant 2009;9:2262-9.   DOI
11 Cypel M, Yeung JC, Liu M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 2011;364:1431-40.   DOI
12 Valapour M, Lehr CJ, Skeans MA, et al. OPTN/SRTR 2018 annual data report: lung. Am J Transplant 2020;20 Suppl s1:427-508.   DOI
13 Van Raemdonck D, Neyrinck A, Verleden GM, et al. Lung donor selection and management. Proc Am Thorac Soc 2009;6:28-38.   DOI
14 Cypel M, Yeung JC, Donahoe L, et al. Normothermic ex vivo lung perfusion: does the indication impact organ utilization and patient outcomes after transplantation? J Thorac Cardiovasc Surg 2020;159:P346-55.
15 De Perrot M, Sekine Y, Fischer S, et al. Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation. Am J Respir Crit Care Med 2002;165:211-5.   DOI
16 Weeder PD, van Rijn R, Porte RJ. Machine perfusion in liver transplantation as a tool to prevent non-anastomotic biliary strictures: rationale, current evidence and future directions. J Hepatol 2015;63:265-75.   DOI
17 Wierup P, Haraldsson A, Nilsson F, et al. Ex vivo evaluation of nonacceptable donor lungs. Ann Thorac Surg 2006;81:460-6.   DOI
18 Snell GI, Levvey BJ, Oto T, et al. Early lung transplantation success utilizing controlled donation after cardiac death donors. Am J Transplant 2008;8:1282-9.   DOI
19 Kaneda H, Waddell TK, de Perrot M, et al. Pre-implantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans. Am J Transplant 2006;6:544-51.   DOI
20 Niikawa H, Okamoto T, Ayyat KS, et al. Prone ex vivo lung perfusion protects human lungs from reperfusion injury. Artif Organs 2022 Jun 3 [Epub]. https://doi.org/10.1111/aor.14328.   DOI
21 Nakajima D, Watanabe Y, Ohsumi A, et al. Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation. J Heart Lung Transplant 2019;38:1214-23.   DOI
22 Inci I, Yamada Y, Hillinger S, Jungraithmayr W, Trinkwitz M, Weder W. Successful lung transplantation after donor lung reconditioning with urokinase in ex vivo lung perfusion system. Ann Thorac Surg 2014;98:1837-8.   DOI
23 Nakajima D, Liu M, Ohsumi A, et al. Lung lavage and surfactant replacement during ex vivo lung perfusion for treatment of gastric acid aspiration-induced donor lung injury. J Heart Lung Transplant 2017;36:577-85.   DOI
24 Haam S, Lee JG, Paik HC, Park MS, Lim BJ. Hydrogen gas inhalation during ex vivo lung perfusion of donor lungs recovered after cardiac death. J Heart Lung Transplant 2018;37:1271-8.   DOI