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http://dx.doi.org/10.5090/kjtcs.2018.51.1.41

Prognostic Implications of Postoperative Infectious Complications in Non-Small Cell Lung Cancer  

Jang, Hyo-Jun (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital)
Song, Jae Won (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital)
Cho, Sukki (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital)
Kim, Kwhanmien (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital)
Jheon, Sanghoon (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital)
Publication Information
Journal of Chest Surgery / v.51, no.1, 2018 , pp. 41-52 More about this Journal
Abstract
Background: Few studies have evaluated the long-term impact of postoperative infectious complications in patients with non-small cell lung cancer (NSCLC). We aimed to determine the impact of infectious complications on long-term outcomes after surgical resection for NSCLC. Methods: We performed a retrospective study of 1,380 eligible patients who underwent pulmonary resection for NSCLC from 2003 to 2012. Complications were divided into infectious complications and non-infectious complications. Kaplan-Meier survival analysis was used to compare unadjusted 5-year cancer-specific survival (CSS) rates and recurrence-free survival (RFS) rates. Cox regression was used to determine the impact of infectious complications on 5-year CSS and RFS. Results: The rate of total complications and infectious complications was 24.3% and 4.3%, respectively. In the node-negative subgroup, the 5-year CSS and RFS rates were 75.9% and 57.1% in patients who had infectious complications, compared to 87.9% and 78.4% in patients who had no complications. Infectious complications were a negative prognostic factor for 5-year RFS (hazard ratio, 1.92; 95% confidence interval, 1.00-3.69; p=0.049). In the node-positive subgroup, the 5-year CSS rate and RFS were 44.6% and 48.4% in patients who had infectious complications, compared to 70.5% and 48.4% for patients who had no complications. Conclusion: Postoperative infectious complications had a negative impact on CSS and RFS in node-negative NSCLC. Our findings may help improve risk assessment for tumor recurrence after pulmonary resection for node-negative NSCLC.
Keywords
Non-small-cell lung carcinoma; Complication; Prognosis;
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