A Study on an Effective Decellularization Technique for a Xenograft Cardiac Valve: the Effect of Osmotic Treatment with Hypotonic Solution
![]() |
Sung, Si-Chan
(Department of Thoracic and Cardiovascular Surgery, School of Medicine, Pusan National University)
Kim, Yong-Jin (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine) Choi, Sun-Young (Seoul National University Hospital Clinical Research Institute, Xenotransplantation Research Center) Park, Ji-Eun (Seoul National University Hospital Clinical Research Institute, Xenotransplantation Research Center) Kim, Kyung-Hwan (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine) Kim, Woong-Han (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine) |
1 | Schoen FJ, Levy RJ. Tissue heart valves: current challenges and future research perspectives. J Biomed Mater Res 199; 47:439-65 DOI ScienceOn |
2 | Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials 2006;27:3675-83 PUBMED |
3 | Booth C, Korossis SA, Wilcox HE, et al. Tissue engineering of cardiac valve prostheses I: development and histological characterization of an acellular porcine scaffold. J Heart Valve Dis 2002;11:457-62 PUBMED |
4 | Dohmen PM, da Costa F, Holinski S, et al. Is there a possiblility for a glutaraldehyde-free porcine heart valve to grow?. Eur Surg Res 2006;38:54-61 DOI ScienceOn |
5 | Kasimir MT, Rieder E, Seebacher G, et al. Comparison of different decellularization procedures of porcine heart valves. Int J Artif Orfgans 2003;26:421-7 DOI |
6 | Avakkol W, Gelehrter S, Goldberg CS, Bove EL, Devaney EJ, Ohye RG. Superior durability of synergraft pulmonary allografts compared with standard cryopreserved allografts. Ann Thorac Surg 2005;80:1610-4 DOI ScienceOn |
7 | Dohomen PM, Lembcke A, Holinski S, et al. Mid-term clinical results using a tissue-engineered pulmonary valve to reconstruct the right ventricular outflow tract during the Ross procedure. Ann Thorac Surg 2007;84:729-36 DOI ScienceOn |
8 | Hirsch D, Drader J, Thomas TJ, et al. Inhibition of calcification of glutaraldehyde pretreated porcine aortic valve cusps with sodium dodecyl sulfate: preincubation and controlled released studies. J Biomed Mater Res 1993;27: 1477-84 DOI ScienceOn |
9 | Hirsch D, Drader J, Thomas TJ, et al. Inhibition of calcification of glutaraldehyde pretreated porcine aortic valve cusps with sodium dodecyl sulfate: preincubation and controlled released studies. J Biomed Mater Res 1993;27: 1477-84 DOI ScienceOn |
10 | Courtman DW, Pereira CA, Kashef V, et al. Development of a pericardial acellular matrix biomaterial-biochemical and mechnical effects of cell extraction. J Biomed Master Res 1994;28:655-66 DOI ScienceOn |
11 | Rieder E, Kasimir MT, Silberhumer G, et al. Decellularization protocols of porcine heart valves differ importantly in efficiency of cell removal and susceptibility of the matrix to recellularization with human vascular cells. J Thorac Cardiovasc Surg 2004;127:399-405 DOI ScienceOn |
12 | Gratzer PF, Harrison RD, Woods T. Matrix alteration and not residual sodium dodecyl sulfate cytotoxicity affects the cellular repopulation of a decellularization matrix. Tissue Engineering 2006;12:2975-83 DOI ScienceOn |
13 | Dahl SL, Koh J, Prabhakar V, Niklason LE. Decellularized native and engineered arterial scaffolds for transplantation. Cell transplant 2003;12:659-66 DOI PUBMED |
14 | Erdbrugger W, Konertz W, Domen PM, et al. Decellularized xenogenic heart valves reveal remodeling and growth potential in vivo. Tissue Eng 2006;12:2059-68 DOI ScienceOn |
15 | Grauss RW, Hazekamp MG, van Vliet S, Gittenberger-de Groot AC, DeRuiter MC. Decellularization of rat aortic valve allografts reduces leaflet destruction and extracellular matrix remodeling. J Thorac Cardiovasc Surg 2003;126: 2003-10 DOI ScienceOn |
16 | Wilcox HE, Korossis SA, Booth A, et al. Biocompatibility and recellularization potential of an acellular porcine heart valve matrix. J Heart Valve Dis 2005;14:228-37 PUBMED |
![]() |