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Thrombolytic Therapy for Repeated Prosthetic Valvular Thrombosis That's Associated with Pregnancy under Heparin Anticoagulation  

Choe, Ju-Won (Department of Thoracic and Cardiovascular Surgery, Chung-Ang University Yongsan Hospital, Chung-Ang University College of Medicine)
Kim, Yong-In L. (Department of Thoracic and Cardiovascular Surgery, Seoul Paik Hospital, Inje University College of Medicine)
Publication Information
Journal of Chest Surgery / v.41, no.4, 2008 , pp. 484-488 More about this Journal
Abstract
During long-term anticoagulation treatment with using heparin in a pregnant patient with a mechanical mitral prosthesis, we observed several anticoagulation-related complications, including repeated prosthetic valve thrombosis. This was found to be caused by heparin resistance due to an anti-thrombin III deficiency. Thrombolytic therapy using urokinase or tissue plasminogen activator (tPA) was successful and safe for her as well as her baby.
Keywords
Anticoagulants; Thrombolysis; Heparin; Antithrombin III; Prosthesis failure;
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