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The Safety and Efficacy of Mediastinoscopy in Non-small Cell Lung Cancer  

Park In-Kyu (Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine)
Cho Sang-Ho (Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine)
Kim Dae-Joon (Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine)
Chung Kyung-Young (Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine)
Publication Information
Journal of Chest Surgery / v.39, no.6, 2006 , pp. 470-474 More about this Journal
Abstract
Background: Mediastinal lymph node metastasis is an important factor for staging and prognosis of non-small cell lung cancer (NSCLC), so accurate diagnosis is essential for treatment. Mediastinoscopy provides histopathological diagnosis of mediastinal lymphnode metastasis in NSCLC. The efficacy of mediastinoscopy was investigated. Material and Method: From Jun, 1999 to Aug, 2005, mediastinoscopic lymph node biopsy was performed to 348 patients with NSCLC. Patients characteristics, radiologic findings, mediastinoscopic results and pathologic stages were evaluated for investigation of safety and efficacy of modiastinoscopy in NSCLC. Result: There was 263 male and 85 female patients and the mean age was $62.1{\pm}8.5$ years. By radiologic study for mediastinal lymph node metastasis, 203 patients were negative and 145 patients were positive. Mean procedure time was $55.5{\pm}16.5$ minutes and biopsy was peformed at $2.2{\pm}1.0$ lymph node stations. There were only transient complications (1.7%) during the procedure, without other complication and mortality. There was 7.8% of false negative result in mediastinoscopy. Sensitivity (77.5% vs 71.9%, p=0.012), specificity (100% vs 74.4%, p=0.00), and accuracy (92.2% vs 73.6%, p=0.00) of mediastinoscopy were more superior than that of radiologic study for the diagnosis of mediastinal lymph node metastasis in NSCLC. Conclusion: Mediastinoscopy is a safe and effective modality for diagnosis of mediastinal lymph node metastasis in NSCLC.
Keywords
Mediastinoscopy; Carcinoma, non-small cell, lung;
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