Browse > Article

The Effects of Packed Red Blood Cell Washing and Circuit Precirculation-Ultrafiltration on the Production of Cytokines by Open Heart Surgery  

전태국 (성균관대학교 의과대학 삼성서울병원 흉부외과)
노준량 (서울대학교 의과대학 흉부외과학 교실)
Publication Information
Journal of Chest Surgery / v.35, no.3, 2002 , pp. 199-208 More about this Journal
Abstract
Background: The washing of packed red blood cells could remove pro-inflammatory mediators, cell debris, and micro-particles contained in packed red blood cells, and the preci-rculation-ultrafiltration (recirculation and ultrafiltration of circuit itself before cardiopulmonary bypass) could attenuate the initial inflammatory reaction and remove the initial proinflam-matory mediators. This study was performed to evaluate whether the washing of packed red blood cells and precirculation-ultrafiltration can reduce the production of cytokines that have an important role in myocardial reperfusion injury. This study investigated the effects of washing the packed red blood cells and precirculation-ultrafiltration on the production of cytokines during and after cardiopulmonary bypass and open heart surgery. Material and Method: Forty eight infants with VSD undergoing open heart surgery under cardiopulmonary bypass were randomized into control group (group C, n=12), washing group (group W, n= 12), precirculation-ultrafiltration group (group F, n: 12), and combined group(washing and precirculation-ultrafiltration, group WF, n=12). Blood samples were obtained before, during, and after the bypass to assess plasma level of tumor necrosis factor-$\alpha$(TNF-$\alpha$), interleukin-6(IL-6), and interleukin-8 (IL-8). Results: Expressions of TNF-$\alpha$ were significantly reduced in combined group (group WF) compared with group C, group W, and group F (p<0.05). Expression of IL-6 were significantly reduced in group W, group F, and group WF compared with group C (p<0.05), but similar among group W, group F, and group WF (p=0.053). Expression of IL-8 were reduced in group W and group WF compared with group C (p<0.05), but similar among group W, group F, and group WF (p=0.067). Conclusion: In conclusion, the washing of packed red blood cells and precirculation-ultrafiltration blunted the increase of TNF-$\alpha$ , IL-6, and IL-8 during and after open heart surgery with cardiopulmonary bypass. However, the clinical benefits of these treatments remains unproven.
Keywords
Cardiopulmonary bypass; Cytokines; Blood cells; Ultrafiltration;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 A prospective randomized study of a modified technique of ultrafiltration during pediatric open heart surgery /
[ Naik SK;Kningt A;Elliott MJ ] / Circulation
2 Negative inotropic effects of cytokines on the heart mediated nitric oxide /
[ Finkel MS;Oddis CV;Jacob TD;Watkins SC;Hattier BG;Simmons CV ] / Science   DOI
3 소아 개심술에 있어서 변형초여과법의 효과 /
[ 전태국;박표원;최용수 ] / 대흉회지   과학기술학회마을
4 Hemofiltration during cardiopulmonary bypass in pediatric cardiac surgery. Effects on hemostasis, cytokines and complement components /
[ Jounois D;Pouard P;Greeley WJ ] / Anesthesiology   DOI   ScienceOn
5 Clinical experience with heparin-coated cardiopulmonary bypass circuits /
[ Pradhan MJ;Fleming JS;NKere UU ] / Perfusion   DOI   ScienceOn
6 Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization /
[ Hennein HA;Ebba H;Rodriguez JL ] / J Thorac Cardiovasc Surg
7 High-volume, zero-valanced hemofiltration to reduce delayed inflammatory response to cardiopulmonary bypass in children /
[ Journois D;Israel-Biet D;Pouard P ] / Anesthesiology   DOI   ScienceOn
8 Inhibition of neutrophil adhesion during cardiopulmonary bypass /
[ Gillinov AM;Redmond JM;Jehr KJ ] / Ann Thorac Surg   DOI   ScienceOn
9 Anticytokine strategies in the treatment of the systemic inflammatory response syndrome /
[ Dinarello CA;Gelfand JA;Wolff SM ] / JAMA   DOI   ScienceOn
10 Ultrafiltration and modifeiltration inpediatric open heart surgery /
[ Elliott M ] / Ann Thorac surg   DOI   ScienceOn
11 Optimal use of cuprannonium rayon hollow-fiber dialyzers /
[ Chan MK;Lau N ] / Int J Artif Organ
12 Effects of inhibition of complement activation using recombinant soluble complement receptor 1 on neutrophil CD11B/CD18 and L-selection expression and release of interleukin-8 and elastase in simulated cardiopulmonary bypass /
[ Finn A;Morgan BP;Rebuck N ] / J Thorac Cardiovasc Surg   DOI   ScienceOn
13 Inflammation and cardiopulmonary bypass /
[ Levy JH;Kelly AB ] / Can J Anesth   DOI   ScienceOn
14 The preparation of red cells depleted of leukocytes. Review and evalution /
[ Meryman HT;Hrnblower M ] / Transfusion   DOI   ScienceOn
15 Circulating cytokines in patients undergoing normothermic cardiopulmonary bypass /
[ Ferring B;Dehoux M;Rolland C;Langlois M;Dsmonts JM ] / J Thorac Cardiovasc Surg
16 The metabolic consequences of a washed cardiopulmonary bypass pump-priming fluid in children undergoing cardiac operations /
[ Ridley PD;Ratcliffe JM;Alberti KGMM;Elliot MJ ] / J Thorac Cardiovasc Surg
17 Expericence with the multiple use of dialyzers /
[ Strokov AG;Poz IL;Baeva LB ] / Ter Arkh
18 Intraoperative autotransfusion in cardiac operation. Effect on inttraoperative and postoperative transfusion requirements /
[ Giordano GF;Goldman DS;Mammana B ] / J Thorac cardiovasc Surg
19 Hemostatic problems, transfusion therapy and cardiopulmonary bypass in surgical /
[ Edmunds LH;Salzman EW;Colman RW(ed.);Hirsh J(ed.);Marder VJ(ed.);Salzman EW(ed.) ] / Hemostasis and Thrombosis
20 Interleukin-10 and interlukin-1 receptor antagonists increase during cardiac surgery /
[ Kawamura T;Wakusawa R;Inada S ] / Can J Anesth   DOI   ScienceOn
21 Temporary oeukocyte depletion reduces ventricular dystunction during prolonged postischemic reperfusion /
[ Wilson IC;Cardner TJ;Dinatale JM ] / J Thorac Cardiovasc Surg
22 Filtration of fentanyl is not the cause of the elevation of arterial blood pressure associated with post-bypass ultrafiltration in children /
[ Hodges UM;Berg S;Naik SK;Bower S;Lloyd-Thomas A;Elliott M ] / J Cardiothorac Vasc Anesth   DOI   ScienceOn
23 complement activation and release of tumor necrosis factor alpha, interleukin-2, interleukin-6, and soluble tumor necrosis factor and interleukin-2 receptors during and after cardiopulmonary bypass in children /
[ Saatvedt K; Lindberg H;Geiran OR ] / Scand J Clin Lab Invest   DOI   ScienceOn
24 Cytokine production and hemofiltration in children undergoing cardio pulmonary bypass /
[ Millar AB;Armstrong L;van der Linden J ] / Ann Thorac Surg   DOI   ScienceOn
25 Filtration of the micoraggregates in stored blood /
[ Solis RT;Gibbs MB ] / Transfusion
26 Aprotinin in perspective /
[ Westaby S ] / Ann Thorac Surg   DOI   ScienceOn
27 Elevation of cytokines during open heart surgery with cardiopulmonary bypass:participation of interleukin 8 and 6 in reperfusion injury /
[ Kawamura T; Wakusawa R;Okada K;Inada S ] / Can J Anesth   DOI   ScienceOn
28 The in flammatory response to cardiopulmonary bypass /
[ Miller BE;Levy JH ] / J Cardiothorac Vasc Anesth   DOI   ScienceOn
29 Effect of hemofiltrated whole blood pump priming on hemodynamics and respiratory function after the arterial switch operation in neonates /
[ Nagashima M;Imai Y;Seo K ] / Ann Thorac Surg   DOI   ScienceOn