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http://dx.doi.org/10.5765/jkacap.220015

Factors Affecting Depressive Symptoms in Children and Adolescents With Epilepsy  

Park, So Hyun (Department of Psychiatry, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine)
Lee, Hyang Woon (Department of Neurology and Medical Science, Ewha Womans University College of Medicine and Ewha Medical Research Institute)
Kim, Ga Eun (Department of Psychiatry, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine)
Kim, Eui-Jung (Department of Psychiatry, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine)
Publication Information
Journal of the Korean Academy of Child and Adolescent Psychiatry / v.33, no.4, 2022 , pp. 106-112 More about this Journal
Abstract
Objectives: We aimed to evaluate the clinical and psychological factors influencing depressive symptoms in children and adolescents with epilepsy. Methods: We administered self-reported questionnaires assessing children's depressive symptoms (Children's Depression Inventory, CDI) and anxiety (Revised Children's Manifest Anxiety Scale, RCMAS) to children and adolescents with epilepsy (n=87, age range=6-17 years). We asked their parents to complete questionnaires on epilepsy-related variables, parental stress (Questionnaire on Resources and Stress, QRS), parental anxiety (State-Trait Anxiety Inventory, STAI), family functioning (Family Adaptability and Cohesion Evaluation Scale, FACES), children's attention problems (Abbreviated Conners Parent Rating Scale Revised, CPRS), and children's behavioral problems (Korean Child Behavior Checklist, K-CBCL). Stepwise multiple regression analysis was performed to identify predictive variables affecting depressive symptoms. Results: Family adaptability (r=-0.240, p=0.026), family cohesion (r=-0.381, p<0.001), children's attention problems (r=0.290, p=0.006), children's anxiety (r=0.714, p<0.001), children's behavioral problems (r=0.371, p<0.001), parental anxiety (r=0.320, p=0.003), and parental stress (r=0.335, p=0.002) were significantly correlated with children's depressive symptoms. Children's anxiety (β=0.655, p<0.001) and parental stress (β=0.198, p=0.013) were significantly related to their depressive symptoms (adjusted R2=0.539). Conclusion: Clinicians should detect and manage children's anxiety and parental stress, which may affect depressive symptoms in children and adolescents with epilepsy.
Keywords
Epilepsy; Child; Adolescent; Depression;
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1 Vega C, Guo J, Killory B, Danielson N, Vestal M, Berman R, et al. Symptoms of anxiety and depression in childhood absence epilepsy. Epilepsia 2011;52:e70-e74.   DOI
2 Baker GA, Spector S, McGrath Y, Soteriou H. Impact of epilepsy in adolescence: a UK controlled study. Epilepsy Behav 2005;6:556-562.   DOI
3 Ettinger AB, Weisbrot DM, Nolan EE, Gadow KD, Vitale SA, Andriola MR, et al. Symptoms of depression and anxiety in pediatric epilepsy patients. Epilepsia 1998;39:595-599.   DOI
4 Cushner-Weinstein S, Dassoulas K, Salpekar JA, Henderson SE, Pearl PL, Gaillard WD, et al. Parenting stress and childhood epilepsy: the impact of depression, learning, and seizure-related factors. Epilepsy Behav 2008;13:109-114.   DOI
5 Chiou HH, Hsieh LP. Parenting stress in parents of children with epilepsy and asthma. J Child Neurol 2008;23:301-306.   DOI
6 Davies S, Heyman I, Goodman R. A population survey of mental health problems in children with epilepsy. Dev Med Child Neurol 2003;45:292-295.   DOI
7 Coulacoglou C, Saklofske DH. The assessment of family, parenting, and child outcomes. In: Coulacoglou C, Saklofske DH, editors. Psychometrics and psychological assessment. Cambridge, MA: Academic Press;2017. p.187-222.
8 Friedrich WN, Greenberg MT, Crnic K. A short-form of the Questionnaire on Resources and Stress. Am J Ment Defic 1983;88:41-48.
9 Spielberger CD, Gorsuch RL, Lushene RE. STAI manual for the state-trait anxiety inventory. Palo Alto, CA: Consulting Psychologists Press;1970.
10 Achenbach TM, Edelbrock CS. Manual for the child behavior checklist and revised child behavior profile. Burlington, VT: University of Vermont;1983.
11 Alwash RH, Hussein MJ, Matloub FF. Symptoms of anxiety and depression among adolescents with seizures in Irbid, Northern Jordan. Seizure 2000;9:412-416.   DOI
12 Herman KC, Ostrander R. The effects of attention problems on depression: developmental, academic, and cognitive pathways. Sch Psychol Q 2007;22:483-510.   DOI
13 Rodenburg R, Stams GJ, Meijer AM, Aldenkamp AP, Dekovic M. Psychopathology in children with epilepsy: a meta-analysis. J Pediatr Psychol 2005;30:453-468.   DOI
14 Kerne V, Chapieski L. Adaptive functioning in pediatric epilepsy: contributions of seizure-related variables and parental anxiety. Epilepsy Behav 2015;43:48-52.   DOI
15 Baki O, Erdogan A, Kantarci O, Akisik G, Kayaalp L, Yalcinkaya C. Anxiety and depression in children with epilepsy and their mothers. Epilepsy Behav 2004;5:958-964.   DOI
16 Thome-Souza S, Kuczynski E, Assumpcao F Jr, Rzezak P, Fuentes D, Fiore L, et al. Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy? Epilepsy Behav 2004;5:988-994.   DOI
17 Tosun A, Gokcen S, Ozbaran B, Serdaroglu G, Polat M, Tekgul H, et al. The effect of depression on academic achievement in children with epilepsy. Epilepsy Behav 2008;13:494-498.   DOI
18 Puka K, Widjaja E, Smith ML. The influence of patient, caregiver, and family factors on symptoms of anxiety and depression in children and adolescents with intractable epilepsy. Epilepsy Behav 2017;67:45-50.   DOI
19 Korean Statistical Information Service. 2020 family survey. The average monthly income of a family [Internet]. Daejeon: Statistics Korea [cited 2022 Feb 1]. Available from: https://kosis.kr/statHtml/statHtml.do?orgId=154&tblId=DT_154001_106&conn_path=I2.
20 Kovacs M. The children's depression, inventory (CDI). Psychopharmacol Bull 1985;21:995-998.
21 Rodenburg R, Marie Meijer A, Dekovic M, Aldenkamp AP. Family predictors of psychopathology in children with epilepsy. Epilepsia 2006;47:601-614.   DOI
22 Olson DH, Portner J, Lavee Y. "Faces III": family adaptability & cohesion evaluation scales, family social science. St Paul, MN: University of Minnesota;1985.
23 Bilgic A, Yilmaz S, Tirac S, Deda G, Kilic EZ. Depression and anxiety symptom severity in a group of children with epilepsy and related factors. Turk Psikiyatri Derg 2006;17:165-172.
24 Bradley RH, Corwyn RF. Socioeconomic status and child development. Annu Rev Psychol 2002;53:371-399.   DOI
25 Russ SA, Larson K, Halfon N. A national profile of childhood epilepsy and seizure disorder. Pediatrics 2012;129:256-264.   DOI
26 Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron 2002;34:13-25.   DOI
27 Park AL, Fuhrer R, Quesnel-Vallee A. Parents? education and the risk of major depression in early adulthood. Soc Psychiatry Psychiatr Epidemiol 2013;48:1829-1839.   DOI
28 Reynolds CR, Richmond BO. What I think and feel: a revised measure of children's manifest anxiety. J Abnorm Child Psychol 1978; 6:271-280.   DOI
29 Ortuno-Sierra J, Garcia-Velasco L, Inchausti F, Debbane M, Fonseca-Pedrero E. New approaches on the study of the psychometric properties of the STAI. Actas Esp Psiquiatr 2016;44:83-92.
30 Conners CK. Symptom patterns in hyperkinetic, neurotic, and normal children. Child Dev 1970;41:667-682.   DOI
31 Wu YP, Follansbee-Junger K, Rausch J, Modi A. Parent and family stress factors predict health-related quality in pediatric patients with new-onset epilepsy. Epilepsia 2014;55:866-877.   DOI
32 Dunn DW, Austin JK, Huster GA. Symptoms of depression in adolescents with epilepsy. J Am Acad Child Adolesc Psychiatry 1999; 38:1132-1138.   DOI
33 Rajendran K, O'Neill S, Halperin JM. Inattention symptoms predict level of depression in early childhood. Postgrad Med 2013;125:154-161.   DOI
34 Li Y, Ji CY, Qin J, Zhang ZX. Parental anxiety and quality of life of epileptic children. Biomed Environ Sci 2008;21:228-232.   DOI
35 Reilly C, Agnew R, Neville BG. Depression and anxiety in childhood epilepsy: a review. Seizure 2011;20:589-597.   DOI