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http://dx.doi.org/10.5765/jkacap.2014.25.3.156

Electroencephalographic Abnormalities in Children and Adolescents with Autism Spectrum Disorder  

Kim, Yangsik (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine)
Ko, Tae-Sung (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine)
Yum, Mi-Sun (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine)
Kim, Eun-Hee (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine)
Kim, Hyo-Won (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine)
Publication Information
Journal of the Korean Academy of Child and Adolescent Psychiatry / v.25, no.3, 2014 , pp. 156-162 More about this Journal
Abstract
Objectives : The aim of this study was to estimate the prevalences of electroencephalographic (EEG) abnormalities and epilepsy in children and adolescents with autism spectrum disorder (ASD). In addition, we intended to identify demographic and clinical correlates of epilepsy in ASD. Methods : A total of 140 children and adolescents (age $7.3{\pm}4.8yrs$, 106 boys) with ASD underwent EEG from January 2010 to December 2013 at Asan Medical Center. Medical records were reviewed for demographic information, clinical characteristics, psychiatric diagnoses and comorbidities, EEG findings and neurological diagnoses. Results : The prevalences of EEG abnormalities and epilepsy in children and adolescents with ASD was 62.1% and 38.6%, respectively. In subjects with seizure-like movements, EEG abnormalities and epilepsy were more frequent than those without seizure-like movements (EEG abnormalities : 92.5% vs. 43.7%, p<.001 ; epilepsy : 90.6% vs. 5.7%, p<.001). ASD subjects who had epilepsy were older (p=.001), had lower full scale intelligence quotient (p<.001) and took more antipsychotics (p=.006) than those who did not. Conclusion : The prevalences of EEG abnormalities and epilepsy in our sample were similar to those from Western countries. Our results suggested a possible association of older age, lower intelligence quotient, and antipsychotics use with epilepsy in ASD. Conduct of further prospective study in a larger sample is needed.
Keywords
Autism Spectrum Disorder; Child and adolescent; Electroencephalography; Epilepsy;
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1 Fombonne E. Is the prevalence of autism increasing? J Autism Dev Disord 1996;26:673-676.   DOI
2 Hughes JR, Melyn M. EEG and seizures in autistic children and adolescents: further findings with therapeutic implications. Clin EEG Neurosci 2005;36:15-20.   DOI   ScienceOn
3 Mandell DS. Psychiatric hospitalization among children with autism spectrum disorders. J Autism Dev Disord 2008;38:1059-1065.   DOI
4 Chez MG, Chang M, Krasne V, Coughlan C, Kominsky M, Schwartz A. Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy Behav 2006;8:267-271.   DOI   ScienceOn
5 Tuchman R, Rapin I. Epilepsy in autism. Lancet Neurol 2002;1:352-358.   DOI   ScienceOn
6 Mulligan CK, Trauner DA. Incidence and behavioral correlates of epileptiform abnormalities in autism spectrum disorders. J Autism Dev Disord 2014;44:452-458.   DOI   ScienceOn
7 Tuchman RF, Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates. Pediatrics 1997;99:560-566.   DOI   ScienceOn
8 Miles JH, Takahashi TN, Bagby S, Sahota PK, Vaslow DF, Wang CH, et al. Essential versus complex autism: definition of fundamental prognostic subtypes. Am J Med Genet A 2005;135:171-180.
9 Hara H. Autism and epilepsy: a retrospective follow-up study. Brain Dev 2007;29:486-490.   DOI   ScienceOn
10 Blatt GJ. The neuropathology of autism. Scientifica (Cairo) 2012; 2012:703675.
11 Viscidi EW, Triche EW, Pescosolido MF, McLean RL, Joseph RM, Spence SJ, et al. Clinical characteristics of children with autism spectrum disorder and co-occurring epilepsy. PLoS One 2013;8: e67797.   DOI
12 Amiet C, Gourfinkel-An I, Bouzamondo A, Tordjman S, Baulac M, Lechat P, et al. Epilepsy in autism is associated with intellectual disability and gender: evidence from a meta-analysis. Biol Psychiatry 2008;64:577-582.   DOI   ScienceOn
13 Spence SJ, Schneider MT. The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatr Res 2009;65:599-606.   DOI   ScienceOn
14 Rapin I, Katzman R. Neurobiology of autism. Ann Neurol 1998;43: 7-14.   DOI   ScienceOn
15 DeLong GR, Heinz ER. The clinical syndrome of early-life bilateral hippocampal sclerosis. Ann Neurol 1997;42:11-17.   DOI   ScienceOn
16 Sutcliffe JS. Genetics. Insights into the pathogenesis of autism. Science 2008;321:208-209.   DOI   ScienceOn
17 Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E, et al. Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci 2010;30:694-702.   DOI   ScienceOn
18 Just MA, Cherkassky VL, Keller TA, Kana RK, Minshew NJ. Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cereb Cortex 2007;17:951-961.   DOI
19 Stafstrom CE, Hagerman PJ, Pessah IN. Pathophysiology of epilepsy in autism spectrum disorders. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies. 4th ed. Bethesda, MD: National Center for Biotechnology Information (US);2012.
20 Volkmar FR, Nelson DS. Seizure disorders in autism. J Am Acad Child Adolesc Psychiatry 1990;29:127-129.   DOI
21 Kim MA, Kim SW, Kim YK, Chung HJ. Epilepsy, EEG abnormalities in children with autism spectrum disorders. J Korean Child Neurol Soc 2009;17:58-69.
22 Lee H, Kang HC, Kim SW, Kim YK, Chung HJ. Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders. Korean J Pediatr 2011;54:22-28.   과학기술학회마을   DOI   ScienceOn
23 Walder B, Tramer MR, Seeck M. Seizure-like phenomena and propofol: a systematic review. Neurology 2002;58:1327-1332.   DOI   ScienceOn
24 Rossi PG, Parmeggiani A, Bach V, Santucci M, Visconti P. EEG features and epilepsy in patients with autism. Brain Dev 1995;17: 169-174.   DOI   ScienceOn
25 Kawasaki Y, Yokota K, Shinomiya M, Shimizu Y, Niwa S. Brief report: electroencephalographic paroxysmal activities in the frontal area emerged in middle childhood and during adolescence in a follow-up study of autism. J Autism Dev Disord 1997;27:605-620.   DOI   ScienceOn
26 Filipek PA, Accardo PJ, Ashwal S, Baranek GT, Cook EH Jr, Dawson G, et al. Practice parameter: screening and diagnosis of autism: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology 2000;55:468-479.   DOI   ScienceOn
27 Johnson CP, Myers SM; American Academy of Pediatrics Council on Children With Disabilities. Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007;120:1183-1215.   DOI   ScienceOn
28 Kanemura H, Sano F, Tando T, Sugita K, Aihara M. Can EEG characteristics predict development of epilepsy in autistic children? Eur J Paediatr Neurol 2013;17:232-237.   DOI   ScienceOn
29 National Institute for Health and Clinical Excellence. Autism: recognition, referral, diagnosis and management of adults on the autism spectrum (Clinical guideline 142) 2012. London: National Institute for Health and Clinical Excellence [updated 2012 Jun; cited 2014 Jun 11]. Available from URL: http://guidance.nice.org.uk/CG142
30 Unal O, Ozcan O, Oner O, Akcakin M, Aysev A, Deda G. EEG and MRI findings and their relation with intellectual disability in pervasive developmental disorders. World J Pediatr 2009;5:196-200.   DOI   ScienceOn
31 Tuchman R, Cuccaro M, Alessandri M. Autism and epilepsy: historical perspective. Brain Dev 2010;32:709-718.   DOI   ScienceOn
32 Saemundsen E, Ludvigsson P, Rafnsson V. Risk of autism spectrum disorders after infantile spasms: a population-based study nested in a cohort with seizures in the first year of life. Epilepsia 2008;49: 1865-1870.   DOI   ScienceOn
33 Hrdlicka M, Komarek V, Propper L, Kulisek R, Zumrova A, Faladova L, et al. Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. Eur Child Adolesc Psychiatry 2004;13:209-213.
34 Howlin P, Goode S, Hutton J, Rutter M. Adult outcome for children with autism. J Child Psychol Psychiatry 2004;45:212-229.   DOI   ScienceOn
35 Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009;65:591-598.   DOI   ScienceOn
36 Jang WS, Hong SD, Shin SH. The Effect of Donepezil on Language Functions in Children with Autism Spectrum Disorders. J Korean Neuropsychiatr Assoc 2006;45:64-68.   과학기술학회마을
37 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Washington, DC: American Psychiatric Association;2013.
38 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. 4th ed., text revision. Washington, DC: American Psychiatric Association;2000.
39 Volkmar FR, Lord C, Bailey A, Schultz RT, Klin A. Autism and pervasive developmental disorders. J Child Psychol Psychiatry 2004;45:135-170.   DOI   ScienceOn
40 Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 2006;368:210-215.   DOI   ScienceOn
41 Kim YS, Leventhal BL, Koh YJ, Fombonne E, Laska E, Lim EC, et al. Prevalence of autism spectrum disorders in a total population sample. Am J Psychiatry 2011;168:904-912.   DOI   ScienceOn
42 Aman MG. Treatment planning for patients with autism spectrum disorders. J Clin Psychiatry 2005;66 Suppl 10:38-45.
43 Kawamura Y, Takahashi O, Ishii T. Reevaluating the incidence of pervasive developmental disorders: impact of elevated rates of detection through implementation of an integrated system of screening in Toyota, Japan. Psychiatry Clin Neurosci 2008;62:152-159.   DOI   ScienceOn
44 Danielsson S, Gillberg IC, Billstedt E, Gillberg C, Olsson I. Epilepsy in young adults with autism: a prospective population-based follow-up study of 120 individuals diagnosed in childhood. Epilepsia 2005;46:918-923.   DOI   ScienceOn
45 Canitano R, Luchetti A, Zappella M. Epilepsy, electroencephalographic abnormalities, and regression in children with autism. J Child Neurol 2005;20:27-31.   DOI   ScienceOn
46 Ogawa S, Kwon CH, Zhou J, Koovakkattu D, Parada LF, Sinton CM. A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice. Brain Res 2007;1168:112-123.   DOI   ScienceOn
47 Hashimoto T, Sasaki M, Sugai K, Hanaoka S, Fukumizu M, Kato T. Paroxysmal discharges on EEG in young autistic patients are frequent in frontal regions. J Med Invest 2001;48:175-180.