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http://dx.doi.org/10.15429/jkomor.2017.17.2.61

Effects of Socheongryong-Tang, a Traditional Chinese Medicine, on Gastrointestinal Motility Disorders (Diabetic Models) in Mice  

Bae, Jinsoo (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University)
Kim, Iksung (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University)
Seo, Byoung-Do (Department of Physical Therapy, Kyungwoon University)
Kim, Byung Joo (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University)
Publication Information
Journal of Korean Medicine for Obesity Research / v.17, no.2, 2017 , pp. 61-67 More about this Journal
Abstract
Objectives: The purpose of this study was to investigate the effects of Socheongryong-tang, a traditional herbal medicine, on gastrointestinal (GI) motility disorders (inflammatory and diabetic models) in mice. Methods: The in vivo effects of Socheongryong-tang on GI motility were investigated by calculating percent intestinal transit rates (ITR) and gastric emptying (GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). GMD models were induced by acetic acid and streptozotocin. Results: In normal ICR mice, ITR and GE values were significantly and dose-dependently increased by the intragastric administration of Socheongryong-tang (0.0025~0.25 g/kg). The ITR values (%) of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by Socheongryong-tang. Conclusions: These results suggest that Socheongryong-tang is a good candidate for the development of a prokinetic agent that may prevent or alleviate GMD.
Keywords
Traditional medicine; Gastrointestinal motility; Gastric emptying; Streptozotocin; Diabetes mellitus;
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Times Cited By KSCI : 4  (Citation Analysis)
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