Browse > Article
http://dx.doi.org/10.15429/jkomor.2017.17.2.119

The Mixed Herbal Extract, CAPA, Prevents Obesity and Glucose Intolerance in Obese Mice  

Song, Miyoung (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University)
Publication Information
Journal of Korean Medicine for Obesity Research / v.17, no.2, 2017 , pp. 119-126 More about this Journal
Abstract
Objectives: This study investigated the effects of the mixed herbal extract from Cinnamomum cassia Blume, Atractylodes macrocephala Koidzumi, Pueraria lobata Benth, and Aconitum carmichaeli Debx (CAPA) on obesity and glucose tolerance in obese mice. Methods: Animals were divided in 6 groups, normal diet, high fat diet (HFD), HFD with CAPA 100 mg/kg (CAPA 100), CAPA 300 mg/kg (CAPA 300), and metformin 200 mg/kg or lorcaserin 10 mg/kg as positive controls, and treated for 16 weeks. Body weight, food intake, fasting blood glucose, and body temperature were checked every week and then organs, blood serums were collected after treatment. The oral glucose tolerance test was also carried out after treatment. Results: Compared to HFD, CAPA extract treated mice showed significant decreases in body weight, adipose tissue weight, lipid accumulations in liver and serum lipid levels without a reduction of food intake. And fasting glucose and glucose tolerance were all improved in the CAPA treated mice. Conclusions: Our results suggest that CAPA extract can prevent diet induced obesity and glucose intolerance without a reduction of energy intake in obese mice.
Keywords
Cinnamomum cassia Blume; Atractylodes macrocephala Koidzumi; Pueraria lobata Benth; Aconitum carmichaeli Debx; Obesity; Glucose;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Song MY, Jung HW, Kang SY, Park YK. Atractylenolide III enhances energy metabolism by increasing the SIRT-1 and $PGC1{\alpha}$ expression with AMPK phosphorylation in C2C12 mouse skeletal muscle cells. Biol Pharm Bull. 2017 ; 40(3) : 339-44.   DOI
2 Song MY, Kang SY, Kang A, Hwang JH, Park YK, Jung HW. Cinnamomum cassia prevents high-fat diet-induced obesity in mice through the increase of muscle energy. Am J Chin Med. 2017 ; 45(5) : 1017-31.   DOI
3 Song MY. Evaluation of efficacy of aconitum carmichaeli debx extract on obesity and glucose tolerance in diet induced obese mice. J Korean Med Obes Res. 2017 ; 17(1) : 29-36.   DOI
4 Song MY. Effect of aconitum carmichaeli debx on energy metabolism in C2C12 skeletal muscle cells. J Korean Med Obes Res. 2016 ; 16(2) : 109-15.   DOI
5 Jung HW, Kang AN, Kang SY, Park YK, Song MY. The root extract of pueraria lobata and its main compound, puerarin prevent obesity by increasing the energy metabolism in skeletal muscle. Nutrients. 2017 ; 9(1) : E33.   DOI
6 Rouru J, Huupponen R, Pesonen U, Koulu M. Subchronic treatment with metformin produces anorectic effect and reduces hyperinsulinemia in genetically obese zucker rats. Life Sci. 1992 ; 50(23) : 1813-20.   DOI
7 Lv WS, Wen JP, Li L, Sun RX, Wang J, Xian YX, et al. The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats. Brain Res. 2012 ; 1444 : 11-9.   DOI
8 Thomsen WJ, Grottick AJ, Menzaghi F, Reyes-Saldana H, Espitia S, Yuskin D, et al. Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization. J Pharmacol Exp Ther. 2008 ; 325(2) : 577-87.   DOI
9 Kumar RB, Aronne LJ. Obesity (Silver Spring). Efficacy comparison of medications approved for chronic weight management. 2015 ; 23 Suppl 1 : S4-7.
10 Landsberg L, Young JB, Leonard WR, Linsenmeier RA, Turek FW. Is obesity associated with lower body temperatures? Core temperature: a forgotten variable in energy balance. Metabolism. 2009 ; 58(6) : 871-6.   DOI
11 Jurgens HS, Schurmann A, Kluge R, Ortmann S, Klaus S, Joost HG, et al. Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol Genom. 2006 ; 25(2) : 234-41.   DOI
12 Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb. 2011 ; 18(8) : 629-39.   DOI
13 Nagai M, Komiya H, Mori Y, Ohta T, Kasahara Y, Ikeda Y. Estimating visceral fat area by multifrequency bioelectrical impedance. Diabetes Care. 2010 ; 33(5) : 1077-9.   DOI
14 Williams LM, Campbell FM, Drew JE, Koch C, Hoggard N, Rees WD, et al. The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases. PLoS One. 2014 ; 9(8) : e106159.   DOI
15 Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et. al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 ; 108(8) : 1167-74.   DOI
16 Economic review. Obesity drug market in Korea. [Internet] Seoul: Economic review; [cited 2017 Oct 20]. Available from: http://www.econovill.com/news/articleView.html?idxno=311914
17 Liang H, Ward WF. PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ. 2006 ; 30(4) : 145-51.   DOI
18 Korea Centers for Disease Control and Prevention (KCDC). Korea national health and nutrition examination survey [Internet]. Cheongju: KCDC; [cited 2017 Oct 29]. Available from: https://knhanes.cdc.go.kr/knhanes/sub04/sub04_04.do.
19 O'Neill HM, Holloway GP, Steinberg GR. AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity. Mol Cell Endocrinol. 2013 ; 366(2) : 135-51.   DOI
20 Kim SH, Plutzky J. Brown fat and browning for the treatment of obesity and related metabolic disorders. Diabetes Metab J. 2016 ; 40(1) : 12-21.   DOI
21 World Health Organization (WHO). Obesity and overweight fact sheet [Internet]. Geneva: WHO; [cited 2017 Oct 29]. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/.
22 Tseng YH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov. 2010 ; 9(6) : 465-82.   DOI
23 Biological Research Information Center (BRIC). Future prospect of development of obesity treatment based on global industry trend [Internet]. Pohang: BRIC; [cited 2017 Oct 20]. Available from: http://www.ibric.org/myboard/read.php?Board=report&id=2370.
24 Daneschvar HL, Aronson MD, Smetana GW. FDA-approved anti-obesity drugs in the united states. Am J Med. 2016 ; 129(8) : 879.e1-6.   DOI
25 European medicines agency (EMA). European Medicines Agency recommends suspension of marketing authorisations for sibutramine [Internet] London: EMA; [cited 2017 Oct 20]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2010/01/WC500069995.pdf.
26 InTechOpen. Why is qi-invigorating therapy in chinese medicine suitable for mitochondrial diseases? [Internet]. London: InTech; [cited 2017 Oct 22]. Available from: https://www.intechopen.com/books/complementary-therapiesfor-the-body-mind-and-soul/why-is-qi-invigorating-therapy-in-chinese-medicine-suitable-for-mitochondrial-diseases-a-bioenergeti.
27 Wallace DC. Mitochondria as chi. Genetics. 2008 ; 179 : 727-35.   DOI
28 Song MY, Kang SY, Oh TW, Kumar RV, Jung HW, Park YK. The roots of atractylodes macrocephala koidzumi enhanced glucose and lipid metabolism in C2C12 myotubes via mitochondrial regulation. Evid Based Complement Alternat Med. 2015 ; 2015 : 643654.